Image_1_Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.pdf by Xiaojie Liu (290772)

“…Exercise training promoted transcriptional activation of BMP4 and associated signaling molecules (p38/MAPK, ATF2, PGC1α, and Smad5) that are involved in browning of adipose tissue. …”

MCPC captures two key features of cortical activity. by Gaspard Oliviers (19976466)

“…<p><b>a</b>, MCPC displays the decrease in neural variability at stimulus onset observed in the primary visual cortex (V1) of cats. …”

Site-Specific Cleavage of Ribosomal RNA in <i>Escherichia coli</i>-Based Cell-Free Protein Synthesis Systems by Jurek Failmezger (3592868)

“…These defective ribosomes accumulate in the cell-free system. We demonstrate that the specific cleavage of the 16S rRNA is triggered by the decreased concentrations of Mg²⁺. …”

Table1_Transcriptome sequencing reveals novel molecular features of SLE severity.XLSX by Xiaojing Zhang (163406)

“…</p><p>Results: By comparing gene expression across groups, we identified 12 differentially expressed genes (DEGs), including 7 upregulated (CEACAM6, UCHL1, ARFGEF3, AMPH, SERPINB10, TACSTD2, and OTX1) and 5 downregulated (SORBS2, TRIM64B, SORCS3, DRAXIN, and PCDHGA10) DEGs in sSLE compared to mSLE. …”

Sirtinol Treatment Reduces Inflammation in Human Dermal Microvascular Endothelial Cells by Angela Orecchia (205756)

“…Using selective inhibitors for Sirt1 and Sirt2, we showed a predominant involvement of Sirt1 inhibition in the modulation of adhesion molecule expression and monocyte adhesion on activated HDMEC. …”

Critical Role of Transient Activity of MT1-MMP for ECM Degradation in Invadopodia by Ayako Watanabe (193956)

“…This transient activity was due to the inhibition by TIMP-2, and the steady state activity of MT1-MMP decreased dramatically at higher TIMP-2 concentrations. …”

Selection of Metastatic Breast Cancer Cells Based on Adaptability of Their Metabolic State by Balraj Singh (167005)

“…Gln-ind cells were more tumorigenic and more metastatic in nude mice than the parental cell line as judged by incidence and time of occurrence. As we decreased the number of cancer cells in xenografts, lung metastasis and then primary tumor growth was impaired in mice injected with parental cell line, but not in mice injected with Gln-ind cells.…”

Table_1_EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies.xlsx by Jennifer J. Newson (6187235)

“…In particular, we show that the most dominant pattern of change, across several disorder types including ADHD, schizophrenia and OCD, is power increases across lower frequencies (delta and theta) and decreases across higher frequencies (alpha, beta and gamma). …”

DataSheet1_Comprehensive analysis of epigenomics and transcriptome data to identify potential target genes associated with obesity.zip by Peili Wu (5714256)

“…Then, the immune microenvironment of adipose tissue was quantified by CIBERSORT, and we found that the content of M0 macrophages and T follicular helper cells in adipose tissue was significantly increased and decreased, respectively, in the obese group. …”

Data_Sheet_1_Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations.pdf by Anbin Chen (11475619)

“…We confirmed a deficit in mitochondrial autophagosome formation under exogenous stress conditions and downregulation of the mitophagy receptor p62, reduced lipidation of LC3B-II, and decreased expression of lysosome protein lysosomal-associated membrane protein 2A (LAMP2A). …”

Data_Sheet_1_Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer’s Disease.PDF by Dawling A. Dionisio-Santos (8840129)

“…To test the hypothesis that an anti-inflammatory immunomodulatory agent might have beneficial effects on amyloid and tau pathology, as well as microglial phenotype, we evaluated glatiramer acetate (GA), a multiple sclerosis drug thought to bias type 2 helper T (T_h2) cell responses and alternatively activate myeloid cells. …”

Data_Sheet_1_In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli.PDF by Sridevi Nagaraja (833270)

“…Moreover, we found that simulating single knockouts of any of the three ion channels, delayed rectifier voltage-gated K⁺ channel (Kv1.1) or mechanosensitive channels Piezo2 or TRPA1, considerably altered the excitability of the nociceptor (i.e., each knockout increased or decreased the number of triggered APs compared to when all channels were present). …”

Data_Sheet_1_Lifelong Adaptation of Gastric Cell Proliferation and Mucosa Structure to Early Weaning-Induced Effects.docx by Kethleen Mesquita da Silva (11425996)

“…At 18 days, EW reduced Tgfβ2, Tgfβ3, and Tgfbr2 and TβRII and p27 levels, which might regulate the proliferative increase at this age. …”

Patterns and Environmental Determinants of Medicinal Plant : Vascular Plant Ratios in Xinjiang, Northwest China by Liping Li (120326)

“…Finally, suggestions for medicinal plant conservation were addressed. We found that (1) medicinal plant ratios were not constant, and they were high in the Tarim Basin which was largely covered by desert, while they were relatively low in mountainous areas, especially in the Tianshan Mountains where the general species richness was high; (2) medicinal plant ratios were not significantly influenced by human activities, indicated by human population density distributions, but they were highly correlated with plant species richness and climate, i.e. ratios decreased with plant species richness and MAP, and were related quadratically with MAT; (3) CMM ratio and UM ratio were more influenced by plant richness than by climate, while KM ratio was more influenced by climate. …”

Data_Sheet_3_Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations.doc by Anbin Chen (11475619)

“…We confirmed a deficit in mitochondrial autophagosome formation under exogenous stress conditions and downregulation of the mitophagy receptor p62, reduced lipidation of LC3B-II, and decreased expression of lysosome protein lysosomal-associated membrane protein 2A (LAMP2A). …”

Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease by Anzu Suzuki (6156881)

“…Assuming that taxonomically neighboring strains have similar hydrogen production, we simulated hydrogen production using intestinal microbiota that we previously reported, and found that PD patients produce a 2.2-fold lower amount of intestinal hydrogen compared to controls. …”

BOLD Signal in Both Ipsilateral and Contralateral Retinotopic Cortex Modulates with Perceptual Fading by Po-Jang Hsieh (251896)

“…</p><h3>Results</h3><p>Blood oxygen-level dependent (BOLD) signal in V1 and ventral retinotopic areas V2v and V3v decreases when the disk subjectively disappears, and increases when it subjectively reappears. …”

When Does Model-Based Control Pay Off? by Wouter Kool (450975)

“…We describe five factors that reduce the effectiveness of the model-based strategy on these tasks by reducing its accuracy in estimating reward outcomes and decreasing the importance of its choices. …”

Synergistic effect of HDACi and EZH2i on schistosomula viability. by Letícia Anderson (2543926)

“…<p>(A) Schistosomula were treated with drugs in five different conditions: control with vehicle (DMSO + Ethanol); 20 μM GSK343; 50 μM GSK343; 1 μM TSA and 1 μM TSA + 20 μM GSK343. …”

Syntheses and X-ray Diffraction Studies of Half-Sandwich Hydridosilyl Complexes of Ruthenium by Alexander L. Osipov (2693335)

“…The crystal structures of <b>1a</b>,<b>1b</b>, <b>2a</b>, <b>2c</b>, <b>5b</b>, <b>5c</b>, <b>5d</b>, and <b>8a</b> have been determined by X-ray structure analysis.…”