Falls risk detection based on spatiotemporal parameters of three-dimensional gait analysis in healthy adult women from 50 to 70 years old by Flávia Martins Gervásio (6507362)

“…<p></p><p>ABSTRACT The aim of this study was to compare and correlate spatiotemporal parameters that would indicate falls risk. Thirty-five healthy women without a history of falls in the previous year were selected. …”

Constriction rate variation produced by partial ligation of the portal vein at pre-hepatic portal hypertension induced in rats by Daren Athiê Boy RODRIGUES (10390476)

“…The calculation of the constriction rate was performed using a specific mathematical formula (1 - π r 2 / π R2) x 100% and the statistical analysis with the Student t test. …”

Fluorine Substituents Reduce Charge Recombination and Drive Structure and Morphology Development in Polymer Solar Cells by Andrew C. Stuart (1703602)

“…While the enhanced <i>V</i>_oc can be ascribed to a lower HOMO level of the polymer by adding more fluorine substituents, the improvement in <i>J</i>_sc and <i>FF</i> are likely due to suppressed charge recombination. …”

Fluorine Substituents Reduce Charge Recombination and Drive Structure and Morphology Development in Polymer Solar Cells by Andrew C. Stuart (1703602)

“…While the enhanced <i>V</i>_oc can be ascribed to a lower HOMO level of the polymer by adding more fluorine substituents, the improvement in <i>J</i>_sc and <i>FF</i> are likely due to suppressed charge recombination. …”

Fluorine Substituents Reduce Charge Recombination and Drive Structure and Morphology Development in Polymer Solar Cells by Andrew C. Stuart (1703602)

“…While the enhanced <i>V</i>_oc can be ascribed to a lower HOMO level of the polymer by adding more fluorine substituents, the improvement in <i>J</i>_sc and <i>FF</i> are likely due to suppressed charge recombination. …”

Image4_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Table1_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.DOCX by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Image3_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Image1_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Supporting data for Neuroprotective role of α-Melanocyte-stimulating hormone on ischemia/reperfusion-induced brain and retinal damage in type 1 diabetic mouse by Rajesh Kumar Goit (9067409)

“…Similarly, neuron death, glial cells activation as well as oxidative and nitrosative stress were significantly decreased in the α-MSH-treated brains. Relative intensities of matrix metallopeptidases 9, cyclooxygenase 2 and nuclear factor-κB were significantly decreased while intensities of Akt, heme oxygenase (HO) 1, HO-2 and B-cell lymphoma 2 were significantly increased in α-MSH treated brain. …”

FXR1P is expressed in neurons of the developing hippocampus. by Denise Cook (201666)

“…</b> FXR1P (isoforms c, d) expression across postnatal development was quantified and normalized against GAPDH expression. FXR1P levels decreased relative to GAPDH. <b>C.</b> We immunostained cryostat sections prepared from a P14 mouse with #ML13 and imaged the hippocampus at 10X (left panel). …”

Image1_Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons.eps by Paula Leyton (19196953)

“…Here using a combination of patch clamp electrophysiology, Ca²⁺ imaging, immunofluorescence, fluorescence recovery after photobleaching (FRAP) and pharmacological approach, we demonstrate that carbachol (Cch) increases firing frequency, intracellular Ca²⁺ and that TRPM4 inhibition using 9-Ph and CBA reduces firing frequency and decreases the peak in intracellular Ca²⁺ induced by Cch in cortical pyramidal neurons in culture. …”

DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status by Kazuaki Nakamura (104267)

“…DNA methylation analysis demonstrated that zebularine induced DNA demethylation, and the GO Biological Process terms “hemophilic cell adhesion”, “regulation of transcription, DNA-dependent” and “Wnt signaling pathway” were found to be significantly enriched in association with demethylated genes. Furthermore, we observed that zebularine treatment decreased β-catenin protein levels in TFK-1 and HuCCT1 cells. …”

Table_1_Biomass Allocation Responses to Root Interactions in Wheat Cultivars Support Predictions of Crop Evolutionary Ecology Theory.DOCX by Yong-He Zhu (12278003)

“…We conclude that the newer cultivar was a weaker competitor but higher-yielding in two ways: (1) it had higher reproductive effort and therefore less allocation to structures that increase competitive ability, and (2) it had reduced root proliferation in response to the roots of neighboring plants. …”

Phase Behavior of Poly(ethylene oxide) in Room Temperature Ionic Liquids: A Molecular Simulation and Deep Neural Network Study by Hyuntae Jung (1836778)

“…We develop united atom models for 1-butyl-2,3-dimethyl­imidazolium ([BMMIM]), 1-ethyl-2,3-dimethyl­imidazolium ([EMMIM]), and 1-ethyl-3-methyl­imidazolium ([EMIM]) in an analogous fashion to previously developed models for 1-butyl-3-methyl­imidazolium ([BMIM]) and tetrafluoroborate ([BF₄]) using symmetry-adapted perturbation theory. …”

Vocal development through morphological computation by Yisi S. Zhang (4866541)

“…During the first two months of life, the spontaneous vocalizations of marmosets undergo (1) a gradual disappearance of context-inappropriate call types and (2) an elongation in the duration of context-appropriate contact calls. …”

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration by Ai Ling Wang (90011)

“…By <em>in vitro</em> modeling increased mtDNA damage induced by rotenone, an inhibitor of mitochondrial complex I, in the RPE, we found that the phagocytic activity was not altered but that there were: 1) increased autophagic markers, 2) decreased lysosomal activity, 3) increased exocytotic activity and 4) release of chemoattractants. …”

Data_Sheet_1_Growth responses to elevated environmental humidity vary between phenological forms of Picea abies.PDF by Arne Sellin (144646)

“…In contrast, the humidity treatments significantly affected shoot size, which decreased in the following order: C > I > H. This finding indicates a certain deceleration of the development of trees’ assimilating surface under elevated air humidity. …”

<i>C9orf72</i> and <i>smcr8</i> mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis by Qiang Shao (112168)

“…<b>Abbreviations</b>: ALS: amyotrophic lateral sclerosis; ATG13: autophagy related 13; BMDMs: bone marrow-derived macrophages; BafA₁: bafilomycin A₁; C9orf72: C9orf72, member of C9orf72-SMCR8 complex; CD68: CD68 antigen; ConA: concanamycin A; dKO: double knockout; DENN: differentially expressed in normal and neoplastic cells; FTD: frontotemporal dementia; GEF: guanine nucleotide exchange factor; IFNB1: interferon beta 1, fibroblast; IFNG: interferon gamma; IL1B/IL-1β: interleukin 1 beta; IL6: interleukin 6; iPSCs: induced pluripotent stem cells; LAMP1: lysosomal-associated membrane protein 1; LPOs: LAMP1-positive organelles; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; LPS: lipopolysaccharide; MTORC1: mechanistic target of rapamycin kinase complex 1; MEFs: mouse embryonic fibroblasts; MNs: motor neurons; NOS2/iNOS: nitric oxide synthase 2, inducible; RAN: repeat-associated non-AUG; RB1CC1/FIP200: RB1-inducible coiled-coil 1; RPS6/S6: ribosomal protein S6; RPS6KB1/S6K1: ribosomal protein S6 kinase, polypeptide 1; SMCR8: Smith-Magenis syndrome chromosome region, candidate 8; SQSTM1/p62: sequestosome 1; TFEB: transcription factor EB; TNF: tumor necrosis factor; TSC1: TSC complex subunit 1; ULK1: unc-51 like kinase 1; v-ATPase: vacuolar-type H⁺-translocating ATPase</p>…”

Cardiac Contractility Structure-Activity Relationship and Ligand-Receptor Interactions; the Discovery Of Unique and Novel Molecular Switches in Myosuppressin Signaling by Megan Leander (459603)

“…Additionally, we believed DrmMS-DrmMS-R1 and DrmMS-DrmMS-R2 interactions would reflect our structure-activity relationship (SAR) data. …”