Knockdown of ERK2, but not ERK1, decreases LPS-induced DNase I accessibility of the G-CSF promoter. by Shwu-Fen Chang (761846)

eNOS phosphorylation increased intracellular ROS generation and decreased cell viability in BH4-depleted cells. by Hu Peng (396074)

“…(B) VEGF-mediated eNOS phosphorylation resulted a significant ROS increase in eNOS overexpressing HEK 293 cells (n = 5 fields, *, <i>p</i> < 0.05). …”

The TLR4 activator LPS decreases photoreceptor viability and reducesWnt-mediated protection from oxidative stress. by Hyun Yi (57741)

“…<p>(A) Muller glia-photoreceptor cultures were incubated for 24 hr in 0.4 mM H₂O₂ to induce oxidative stress, with and without recombinant Wnt3a (150 ng/ml) or the TLR4 activator LPS (5 and 50 µg/ml). …”

Decrease of citric acid produced by <i>Aspergillus niger</i> through disruption of the gene encoding a putative mitochondrial citrate-oxoglutarate shuttle protein by Kohtaro Kirimura (414508)

miR-143 overexpression decreases human colon carcinoma cell tumor xenograft growth in nude mice. by Pedro M. Borralho (217909)

Comparison of SF-36 scores of participants with residual limb pain with a VAS score ≥5 and participants with a VAS score <5. by Martin C. Berli (9427264)

Interactions between αv-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain by Sangeet Lal (776570)

“…<div><p>Background</p><p>We tested the hypothesis that αv-integrin and the human epidermal growth factor receptor type 2 (HER2) interact with each other in brain trophic metastatic breast cancer cells and influence their invasive phenotype.…”

Inhibition of TRPC3 decreases ATP- and OAG-induced Ca²⁺ transients in striatal astrocytes. by Karin M. Streifel (653838)

“…Prior treatment with Pyr3 for 30 minutes at 37°C decreased the Ca²⁺ response to ATP, whereas only a modest additive effect was observed with Pyr3 in the presence of 10 µM MPP⁺. …”

A Diverse Family of Host-Defense Peptides (Piscidins) Exhibit Specialized Anti-Bacterial and Anti-Protozoal Activities in Fishes by Scott A. Salger (3072093)

“…The Class I piscidins (22 amino acids in length; striped bass and white bass piscidin 1 and piscidin 3) show broad-spectrum activity against bacteria and ciliated protozoans, while the Class III piscidins (55 amino acids in length; striped bass and white bass piscidin 6 and striped bass piscidin 7) primarily show anti-protozoal activity. The Class II piscidins (44–46 amino acids in length; striped bass and white bass piscidin 4 and white bass piscidin 5) have a level of activity against bacteria and protozoans intermediate to Classes I and III. …”

Decreased antihyperglycemic drug use driven by high out-of-pocket costs despite Medicare coverage gap closure by Mugdha Gokhale (8676201)

“…<a><b>Objectives</b></a>: <a>Using the 2016 Medicare part D coverage gap as an example, we explored effects of increased out-of-pocket costs on adherence to branded </a>dipeptidyl peptidase-4 inhibitors (DPP-4i) in patients without financial subsidies, relative to subsidized patients who do not experience increased spending during the gap. …”

Frequency of IL-17 and/or IL-22 expressing mucosal CD4+T cells decreases by progression of Fiebig stage. by Alexandra Schuetz (327671)

“…<p>To quantify the expression of Il-17 and IL-22 in CD4+T cells, mucosal and peripheral mononuclear cells were stimulated for 5 hours with 40 ng/mL PMA and 1 µM Ionomycin. Gating strategy of sigmoid colon Th17 and Th22 CD4+T cells is shown for a FI subject (<b>a</b>) and representative flow cytometry plots including unstimulated controls (unstim) gated on CD4+T cells showing expression of IL-17 and/or IL-22 in FI (<b>b</b>), FIII (<b>c</b>) and FV (<b>d</b>) in the sigmoid colon. …”

MeHg Exposure Makes O-2A/OPCs More Oxidized, Suppresses BrdU Incorporation, and Decreases Cell Division in Clonal Assays by Zaibo Li (273729)

“…<div><p>(A) Purified O-2A/OPCs were grown in the presence of 10-ng/ml PDGF overnight. …”

Image_1_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.tif by Kanako Iwasaki (16451151)

“…</p>Methods<p>In this study, we explored the direct role of IGF1R in β-cell function and senescence using two independent mouse models with decreased IGF1/IGF1R signaling: a) Ames Dwarf mice (Dwarf ^+/+), which lack growth hormone and therefore have reduced circulating levels of IGF1, and b) inducible β-cell-specific IGF1R knockdown (βIgf1rKD) mice.…”

Table_1_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.docx by Kanako Iwasaki (16451151)

“…</p>Methods<p>In this study, we explored the direct role of IGF1R in β-cell function and senescence using two independent mouse models with decreased IGF1/IGF1R signaling: a) Ames Dwarf mice (Dwarf ^+/+), which lack growth hormone and therefore have reduced circulating levels of IGF1, and b) inducible β-cell-specific IGF1R knockdown (βIgf1rKD) mice.…”

Image_3_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.tif by Kanako Iwasaki (16451151)

“…</p>Methods<p>In this study, we explored the direct role of IGF1R in β-cell function and senescence using two independent mouse models with decreased IGF1/IGF1R signaling: a) Ames Dwarf mice (Dwarf ^+/+), which lack growth hormone and therefore have reduced circulating levels of IGF1, and b) inducible β-cell-specific IGF1R knockdown (βIgf1rKD) mice.…”

Knockdown of Hsp90α or Hsp90β with siRNA decreased the proportion of extracellular FN matrix. by Morgan C. Hunter (513136)

V5-SgG2 transfection in the epidermis modifies the termination site of peptidergic FNE. by Jorge Rubén Cabrera (685511)

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene by Kiyoshi Mori (289003)

High concentrations of UA lead to decrease of TRACP 5b levels. by Zhi-Qi Wu (847506)