Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Decreased β-cell mass in Hq mutant mice. by Fabienne T. Schulthess (13268705)

Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand by David Hauton (341981)

“…Hearts of male offspring subjected to Maternal Hypoxia showed a 20% decrease in cardiac output (<i>P</i><0.05), despite recording a 2-fold increase in glucose oxidation (<i>P</i><0.01) and 2.5-fold increase (<i>P</i><0.01) in palmitate oxidation. …”

Image_5_Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.TIF by Tomohiro Takano (9227690)

“…We further investigated the MLN DCs, and a significant decrease in RALDH2 gene expression was observed in MLN DCs from aged mice. …”

Palmitic acid decreases cell migration by increasing RGS2 expression and decreasing SERCA expression by Octavio Galindo-Hernandez (10350992)

“…Also, overexpression of individual proteins, RGS2 and SERCA, produced a decrease and an increase on cell migration, respectively. …”

Deletion of <i>sagA</i> alone results in a decrease in nasopharyngeal infection. by Blake A. Shannon (14197601)

UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes. by Eric L. Van Nostrand (30730)

“…The histogram indicates the distribution of genes by average fold-change upon <i>unc-62</i> RNAi. For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”

KCl treatment increases Elk1 SUMOylation and decreases katanin-p60 expression. by Ece Selçuk (436963)

Table_2_Sub-Inhibitory Concentrations of Chlorhexidine Induce Resistance to Chlorhexidine and Decrease Antibiotic Susceptibility in Neisseria gonorrhoeae.XLSX by Jolein G. E. Laumen (11754755)

Fold decrease in virulence gene expression of <i>Salmonella in vivo</i> and <i>in vitro</i>^a. by Xiaojian Yang (295141)

“…Values represent down-regulation (fold-decrease) of gene expression.</p>#<p>Value for each gene represents a significant difference (<i>P</i><0.05) between the treatment and control samples in the <i>in vitro</i> experiment. …”

Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol by Fabrice E. Graf (469055)

“…Here we describe two different kinds of <i>TbAQP2</i> mutations found in <i>T. b. gambiense</i> field isolates: simple loss of <i>TbAQP2</i>, or loss of wild-type <i>TbAQP2</i> allele combined with the formation of a novel type of <i>TbAQP2/3</i> chimera. …”

Genes whose expression was decreased by 1 mM ouabain by more than 2-fold. by Larisa V. Smolyaninova (3600053)

The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. by Richard Junior Zapata Dongo (17912565)

Decreased biofilm formation in the Δ<i>tad123</i> mutant cells. by Tra-My Duong-Nu (7300970)

Acute myocardial infarction changes bone marrow cell composition and decreases endothelial differentiation capability. by Ming-Yao Chang (700415)

“…<p><b>(A)</b> CD14 positive cells increased at day 1 post-MI while the CD16 positive cell decreased at day 4 and day 7 after infarction in <b>B</b> with n ≥3 per groups. …”

SARS-CoV‑2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity by Mert Golcuk (10789806)

SARS-CoV‑2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity by Mert Golcuk (10789806)

Table 2_Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver dise... by Elżbieta Supruniuk (16736637)

S5 Fig - by Meihui Chen (1670020)

Gene ontology biological processes overrepresented among genes exhibiting decreased expression in human psoriasis. by William R. Swindell (175427)

“…<p>A total of 3540 transcripts were identified as significantly decreased in psoriatic plaques obtained from human patients relative to normal skin obtained from control subjects (FDR-adjusted P<0.05 and log₂-transformed fold-change less than -0.50). …”