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Phenethyl isothiocyanate activates leptin signaling and decreases food intake
Published 2018“…Leptin is a weight-reducing hormone produced by adipose tissue, which decreases food intake <i>via</i> hypothalamic leptin receptors (Ob-Rb) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. …”
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Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients
Published 2014“…<div><p>Background</p><p>There is increasing evidence that chronic inflammation is an important determinant in insulin resistance and in the pathogenesis of type 2 diabetes (T2D). MicroRNAs constitute a newly discovered system of cell regulation and in particular two microRNAs (miR-146a and miR-155) have been described as regulators and biomarkers of inflammation.…”
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Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study
Published 2016“…Direct bilirubin and the arterial oxygen tension/fraction of inspired oxygen ratio were significantly higher in the SLED group. We identified the following risk factors (sensitivities/specificities) for mortality in severe leptospirosis: age ≥ 55 years (67%/91%); serum urea ≥ 204 mg/dl (100%/70%); creatinine ≥ 5.2 mg/dl (100%/58%); Acute Physiology and Chronic Health Evaluation II score ≥ 39.5 (67%/88%); Sequential Organ Failure Assessment score ≥ 20.5 (67%/85%); and inspiratory pressure ≥ 31 mmHg (84%/85%).…”
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FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells.
Published 2019“…(B) Following 24 hours of treatment with FTY720, the proliferation of HuH6 cells measured using the CellTiter 96 cell proliferation assay was significantly decreased (IC<sub>50</sub> = 6.4 μM, p ≤ 0.05). (C) HuH6 cells were plated and allowed to reach 80% confluence, at which time the media was changed for fresh media (0, 5, or 8 μM FTY720) and a standard scratch wound was made. …”
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Beta-catenin signaling is decreased in intermediate progenitor cells.
Published 2010“…<p>(<b>A</b>) Cortex from E14.5 Axin2-d2EGFP transgenic mice stained for GFP (green), Tbr2 (red), and DNA (blue). …”
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…<b>(C)</b> I-V curves of DHK sensitive currents obtained form <b>(B)</b> as a result of subtractions of averages of 2 I-V curves in presence of DHK from averages of 4 I-V curves in the absence of DHK at corresponding [Glu<sup>-</sup>]<sub>e</sub> and [Na<sup>+</sup>]<sub>e</sub>. …”
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Image_2_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg
Published 2021“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”
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Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses
Published 2025“…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2023“…To investigate the effect of λ5 and/or B cells on bone acquisition over time, we developed a panel of J<sub>H</sub><sup>-/-</sup>, λ5<sup>-/-</sup>, J<sub>H</sub><sup>-/-</sup> λ5<sup>-/-</sup>, and wild-type (WT) BALB/c mice and then studied postnatal bone development and aging in these mice at one, six, twelve, and twenty-two months of age. …”
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2022“…To investigate the effect of λ5 and/or B cells on bone acquisition over time, we developed a panel of J<sub>H</sub><sup>-/-</sup>, λ5<sup>-/-</sup>, J<sub>H</sub><sup>-/-</sup> λ5<sup>-/-</sup>, and wild-type (WT) BALB/c mice and then studied postnatal bone development and aging in these mice at one, six, twelve, and twenty-two months of age. …”