Zinc Coordination Is Required for and Regulates Transcription Activation by Epstein-Barr Nuclear Antigen 1 by Siddhesh Aras (263042)

“…Point mutants of EBNA1 that disrupt zinc coordination also prevent self-association, and do not activate transcription cooperatively. Further, we demonstrate that UR1 acts as a molecular sensor that regulates the ability of EBNA1 to activate transcription in response to changes in redox and oxygen partial pressure (pO₂). …”

DataSheet1_Kinetically Stabilizing Mutations in Beta Tubulins Create Isotype-Specific Brain Malformations.PDF by Kristen Park (10577384)

“…How these mutations impact tubulin activity to give rise to distinct developmental consequences is poorly understood. Here we report two patients exhibiting brain malformations characteristic of tubulinopathies and heterozygous T178M missense mutations in different β-tubulin genes, TUBB2A or TUBB3. …”

Expression Levels of <em>LCORL</em> Are Associated with Body Size in Horses by Julia Metzger (149151)

“…We could demonstrate a significant association of the relative <em>LCORL</em> expression levels with the size of the horses and the BIEC2-808543 genotypes within and across horse breeds. …”

Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway by Krista M. Heinonen (223453)

“…Wnt4 also improved HPC activity in a competitive reconstitution model in a cell-autonomous, Jnk2-dependent manner. Lastly, we identified Fz6 as a receptor for Wnt4 in immature HPCs and showed that the absence of Wnt4 led to a decreased expression of four polarity complex genes.…”

Covariance of shape fluctuations and eigenworms. by Greg J. Stephens (44424)

“…Worm images are recorded at times synchronized to a heat pulse and we display <i>σ</i>²<i>_K</i> aligned with this pulse (red line). …”

Table_1_Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.DOCX by Liping Shan (9418196)

“…Inversely, the ectopic expression of c-Myc reversed the inhibition of cell growth and enhancement of apoptosis by the knockdown of CCAT1. We also verified that anti-apoptosis protein B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1) decreased along with the deregulation of CCAT1, whereas the expression of Bcl-2 and Mcl-1 restored in cells that were transfected sh-CCAT1 and c-Myc simultaneously. …”

Table_1_Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.DOCX by Liping Shan (9418196)

“…Inversely, the ectopic expression of c-Myc reversed the inhibition of cell growth and enhancement of apoptosis by the knockdown of CCAT1. We also verified that anti-apoptosis protein B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1) decreased along with the deregulation of CCAT1, whereas the expression of Bcl-2 and Mcl-1 restored in cells that were transfected sh-CCAT1 and c-Myc simultaneously. …”

Isoaspartate Accumulation in Mouse Brain Is Associated with Altered Patterns of Protein Phosphorylation and Acetylation, Some of Which Are Highly Sex-Dependent by Zhenxia Qin (311680)

“…No changes in phosphorylation were found in synapsins I and II at Ser-603, in CRMP2 at Ser-522 or Thr-514, in DARPP-32 at Thr-34, or in PDK1 at Ser-241. …”

Data_Sheet_1_Identification and Characterization of Cinnamyl Alcohol Dehydrogenase Encoding Genes Involved in Lignin Biosynthesis and Resistance to Verticillium dahliae in Upland C... by Haipeng Li (274506)

“…Silencing each of the three CADs impaired the defense-induced lignification and salicylic acid biosynthesis in stem, and compromised resistance to V. dahliae. Moreover, our study showed that silencing the three GhCADs severely affected the biosynthesis of S-lignin, leading to a decrease of the syringyl/guaiacyl (S/G) ratio. …”

Mean soil organic carbon stocks by soil material for various successional stages (Yng  =young, Int  =intermediate, DL  =drained lake) within four soil landscapes by M Torre Jorgenson (557154)

“…To address this complexity, we used a chronosequence approach to assess changes in vegetation composition, water storage and soil organic carbon (SOC) stocks along successional gradients within four landscapes: (1) rocky uplands on ice-poor hillside colluvium, (2) silty uplands on extremely ice-rich loess, (3) gravelly–sandy lowlands on ice-poor eolian sand and (4) peaty–silty lowlands on thick ice-rich peat deposits over reworked lowland loess. …”

Environmental DNA based biomonitoring for hatchery-raised fish in riverine habitats before and after recordable flood event by Seiji Miyazono (10489421)

“…We also examined the spatiotemporal patterns of the Ayu eDNA concentrations and the relationships with tributary discharge, width, and depth to examine if the relative abundance changes could be related to tributary size. …”

Data_Sheet_1_The Impact of Fertilizer Amendments on Soil Autotrophic Bacteria and Carbon Emissions in Maize Field on the Semiarid Loess Plateau.docx by Jinbin Wang (291754)

“…<p>Soil autotrophic bacteria play a crucial role in regulating CO₂ fixation and crop productivity. …”

Dataset: Does livestock grazing affect sediment deposition and accretion rates in salt marshes? by Stefanie Nolte (8551640)

“…<div>Accretion rates, defined as the vertical growth of salt marshes measured in mm per year, may be influenced by grazing livestock in two ways: directly, by increasing soil compaction through trampling, and indirectly, by reducing aboveground biomass and thus decreasing sediment deposition rates measured in g/m² per year. …”

Data_Sheet_1_Picoeukaryotic Diversity And Activity in the Northwestern Pacific Ocean Based on rDNA and rRNA High-Throughput Sequencing.docx by Feipeng Wang (430627)

“…However, their biodiversity and activity are poorly studied in open ocean systems, such as the northwestern Pacific Ocean, which is characterized by a complex hydrological setting. Here, we investigated the diversity and activity of picoeukaryotes in the northwestern Pacific Ocean using high-throughput sequencing targeting the V9 region of 18S rDNA and rRNA. …”

Rotigotine protects against oxidized low-density lipoprotein(ox-LDL)-induced damages in human umbilical vein endothelial cells(HUVECs) by Hui Kang (579945)

“…Our findings show that Rotigotine suppresses the expressions of low-density lipoprotein receptor (LDL-R), proprotein convertase subtilisin/kexin type 9 (PCSK-9), and sterol regulatory element-binding protein (SREBP-2). It also inhibits ox-LDL-induced cholesterol accumulation in endothelial cells (ECs), improves U937 monocytes adhesion, and decreases the representation of NADPH oxidase (NOX-4) and generation of reactive oxygen species (ROS) in endothelial cells (ECs). …”

Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome by Hemant Bengani (425074)

“…It down regulates reporter gene expression in HEK cells and the repression is dependent on polycomb group of proteins (PcG). We demonstrate that PRE-PIK3C2B interacts directly with YY1 <i>in vitro</i> and recruits PRC2 complex <i>in vivo</i>. …”

Expression of a Constitutively Active Calcineurin Encoded by an Intron-Retaining mRNA in Follicular Keratinocytes by Atsushi Fujimura (227683)

“…Overexpression of cyclin G2 arrested the cell cycle in follicular keratinocytes <em>in vitro</em> and the Cn inhibitor, cyclosporin A, inhibited nuclear localization of NFATc2, resulting in decreased cyclin G2 expression in follicular keratinocytes of rats <em>in vivo</em>. …”

Insights into the Prostanoid Pathway in the Ovary Development of the Penaeid Shrimp <i>Penaeus monodon</i> by Wananit Wimuttisuk (467904)

“…When prostaglandin biosynthesis was examined in different stages of shrimp ovaries, we found that the amounts of <i>prostaglandin F synthase</i> gene transcripts and PGF_2α decreased as the ovaries matured. …”

HIF-1α Signaling Activation by Post-Ischemia Treatment with Astragaloside IV Attenuates Myocardial Ischemia-Reperfusion Injury by Jingwen Si (631873)

“…Furthermore, after treatment with Ast IV, post-ischemic cardiac functional recovery and lactate dehydrogenase (LDH) release in the coronary flow (CF) were improved, and the myocardial infarct size was decreased. Moreover, the number of apoptotic cells was reduced, and the upregulation of the anti-apoptotic protein Bcl2 and downregulation of the pro-apoptotic protein Caspase3 were reversed. 2-MeOE2 reversed these effects of Ast IV on IR-injured hearts. …”

Supplementary Material for: The Effects of Consuming <b><i>Cannabis</i></b> Flower for Treatment of Fatigue by Li X. (3218241)

“…<b><i>Results:</i></b> On average, 91.94% of people experienced decreased fatigue following consumption with an average symptom intensity reduction of 3.48 points on a 0–10 visual analog scale (SD = 2.70, <i>d</i> = 1.60, <i>p</i> < 0.001). …”