Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/S... by Xue-Ming Wang (9768049)

“…ATF3 could reduce the apoptosis rate of keloid fibroblast cells. Molecularly, we found that ATF3 promoted BCL2 level and inhibit the expression of BCL2 associated agonist of cell death (Bad), Caspase3 and Caspase9 in keloid fibroblast cells. …”

Distinct expression patterns of Hh-associated genes in control and patient-derived iPSCs under osteogenic conditions. by Daigo Hasegawa (4439164)

“…<p>We investigated two controls (KDiPS and 201B7) and four Gorlin iPS cases derived from different patients. …”

Supplementary file 1_Emergency department overcrowding: first Swiss application of the Emergency Department Work Index and risk factors for overcrowding.pdf by Aline Herzog (22589720)

“…To investigate predictors of overcrowding, we grouped ED visits with an EDWIN ≤2 as not overcrowded and those with an EDWIN >2 as overcrowded and performed multivariable regression analysis.…”

DataSheet1_Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation.pdf by Bastien Guillot (14661827)

“…</p><p>Methods: In this study, we investigated the involvement of EPAC1 and EPAC2 isoforms in the genesis of AF in wild type (WT) mice and knockout (KO) mice for EPAC1 or EPAC2. …”

cGMP-Dependent Protein Kinase Inhibition Extends the Upper Temperature Limit of Stimulus-Evoked Calcium Responses in Motoneuronal Boutons of <i>Drosophila melanogaster</i> Larvae by Jennifer L. Krill (192560)

“…We found that PKG activity modulates presynaptic neuronal Ca²⁺ responses during acute hyperthermia, where PKG activation makes neurons more sensitive to temperature-induced failure of Ca²⁺ flux and PKG inhibition confers thermotolerance and maintains normal Ca²⁺ dynamics under the same conditions. …”

DataSheet1_Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation.pdf by Bastien Guillot (14661827)

“…</p>Methods<p>In this study, we investigated the involvement of EPAC1 and EPAC2 isoforms in the genesis of AF in wild type (WT) mice and knockout (KO) mice for EPAC1 or EPAC2. …”

Intestinal Cell Tight Junctions Limit Invasion of <i>Candida albicans</i> through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the I... by Marianne Goyer (2550589)

“…Moreover, treatment with a pharmacological inhibitor of endocytosis decreased invasion of the fungus into Caco-2 cells displaying altered TJ, suggesting that facilitating access of the yeast to the basolateral side of intestinal cells promotes endocytosis of <i>C</i>. …”

Isoform-specific Tutl overexpression differentially regulates dendrite branching in class II and III da neurons. by Mikolaj J. Sulkowski (177479)

“…<p>Representative tracings of class II ldaA (<b>A–C</b>) and class III v'pda (<b>E–G</b>) neurons from third instar larvae. …”

Supplemental Figures for Manuscript L-00289-2020R1 by Andrew Dylag (10159250)

“…</i>Both <i>Tgfbr2</i> and <i>Tgfbr3</i> showed strong trends for decreases in O_2-treated animals. …”

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy by Eleni N. Tsakiri (6614297)

“…Ubiquitous or tissue specific proteasome dysfunction triggered systemic proteome instability and activation of PN modules, including macroautophagy/autophagy, molecular chaperones and the antioxidant cncC (the fly ortholog of NFE2L2/Nrf2) pathway. Also, proteasome KD increased genomic instability, altered metabolic pathways and severely disrupted mitochondrial functionality, triggering a cncC-dependent upregulation of mitostatic genes and enhanced rates of mitophagy. …”

Data_Sheet_1_Aberrant Dynamic Functional Connectivity of Default Mode Network in Schizophrenia and Links to Symptom Severity.PDF by Mohammad S. E. Sendi (10322663)

“…We validated our results across two datasets. These results support the potential of dFC for use as a biomarker of schizophrenia and shed new light upon the relationship between schizophrenia and DMN dynamics.…”

Scheme of the kinetic model. by Maria José Ramírez-Bajo (515922)

“…Limiting rates for HK (<i>V_HK</i>) and PFK (<i>V_PFK</i>) decrease at increasing values for Hg²⁺ and Cd²⁺ following <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080018#pone.0080018.e001" target="_blank">equations (1)</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080018#pone.0080018.e002" target="_blank">(2)</a>, respectively for Hg²⁺ and Cd²⁺, with <i>V⁰_HK</i> = 63.0 nmol mg prot⁻¹ min⁻¹ and <i>V⁰_PFK</i> = 434 nmol mg prot⁻¹ min⁻¹.…”

Data_Sheet_1_Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes.xlsx by Mie Korslund Wiinblad Crusell (9555401)

“…The gut microbiota was characterized by 16S rRNA gene amplicon sequencing (V1–V2). Differences in diversity and composition according to maternal GDM status were assessed, addressing potential confounding by mode of delivery, perinatal antibiotics treatment, feeding and infant sex.…”

New types of behavioral inference from the FLIC system. by Jennifer Ro (590372)

“…<p>(A) Flies spent 10% of their time in behaviors we categorized as tasting two foods prior to making their first meal choice. …”

Northern blot analysis of total RNA extracted from primary cultures of SECs or MNPs at 24 h after isolation either untreated (0 h) or treated with IFN-γ (1000 (10) or 10000 (10) U/... by Katrin Neubauer (48437)

“…Five μg of total RNA was separated on agarose gel, blotted and hybridised with a P-dCTP-labeled cDNA probe specific for rat PECAM-1. …”

Influence of flooding on exchangeability and release of stable and radioactive cesium in contaminated paddy soil by Shokichi Wakabayashi (3872428)

“…Compared with a control treatment using sodium sulfate instead of sodium hydrosulfite, the total RCs extracted by the reducing treatment was 42% lower, indicating that soil reduction decreases RCs exchangeability. Through these analyses of ¹³³Cs and RCs, we conclude that soil flooding influences the mobility of aged RCs through two opposite effects: the release of exchangeable RCs into soil solution is enhanced with increased ammonium, while the exchangeable RCs itself decreases due to soil reduction.…”

Avoided recurrences and costs with adjuvant atezolizumab for patients with early non-small cell lung cancer in Europe by Alastair Greystoke (9562178)

“…Immunotherapies such as atezolizumab may delay or prevent recurrence if given after surgery (known as “adjuvant” treatment) to appropriate patients, but the benefits for all suitable patients remain unclear. We developed a mathematical model based on clinical trials and real-world data that estimated ~5000 recurrences avoided over a 10-year period when adjuvant atezolizumab was available for eligible patients in 5 European countries. …”

Data and code from: Support for an area–heterogeneity tradeoff for biodiversity in croplands by Sara Khan (761220)

“…We also proposed two factors that could change the point at which the effect of increasing crop diversity shifts from positive to negative. …”

presentation_1.PDF by Francesco Tavanti (1524319)

“…Starting from an alkaline-free sepiolite crystalline model, we built three models with stoichiometry Mg₃₂₀Si₄₄₀Al₄₀O₁₂₀₀(OH)₁₆₀X⁺_40·480H₂O. …”

Cooperation of Sumoylated Chromosomal Proteins in rDNA Maintenance by Yoshimitsu Takahashi (270156)

“…Upon characterization of sumoylated proteins involved in rDNA maintenance, we established that Top1p and Top2p, which are sumoylated by Siz1p/Siz2p, most likely collaborate with substrates of Mms21p to maintain rDNA integrity. …”