Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria by Patricia A. Reis (109310)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

DataSheet_1_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.zip by Xiao-yang Gong (13103400)

“…A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Image 1_HMOS 2’FL and 3FL prevent house dust mite induced proinflammatory cytokine release in vitro and decrease specific IgE production in a murine allergic asthma model.pdf by Marit Zuurveld (14349609)

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

<i>jun-1</i> mutants are highly susceptible to both Bt strains, while <i>elt-2</i> silencing decreased survival on Bt679 but increased survival on Bt247. by Alejandra Zárate-Potes (9415842)

Dynamics of nocodazole washout upon Mad2 overexpression. by Alma Beatrix Stier (20903134)

Toroidal metamaterials. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Human tissue dielectric parameters. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Human head modeling. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Variations in SAR for individual organizations. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Shoot-to-root translocation of GmNN1/FT2a regulates soybean nodulation. by Xinxin Li (281237)

Data_Sheet_2_Decreased default mode network functional connectivity with visual processing regions as potential biomarkers for delayed neurocognitive recovery: A resting-state fMRI... by Zhaoshun Jiang (7478243)

“…The algorithm performance was evaluated by a permutation test.</p>Results<p>We found significantly decreased DMN connectivity with the brain regions involved in visual processing in DNR patients than in non-DNR patients. …”

FAK, but not Pyk2 is required for GPVI-mediated ROS generation and platelet aggregation. A. by Naadiya Carrim (664456)

“…<p>Washed human platelets (2.5×10⁸/mL) preloaded with 10 µM H₂DCFDA (for ROS experiments only) were pre-treated with vehicle control (0.1% DMSO), FAK inhibitor (1 µM PF-228), Pyk2 inhibitor (10 µM Tyrphostin A9) or Syk inhibitor (5 µM BAY), then stimulated with 1 µg/mL CRP and monitored for ROS generation (i) and platelet aggregation (ii). …”

Spinocerebellar ataxia type 11-associated alleles of <i>Ttbk2</i> dominantly interfere with ciliogenesis and cilium stability by Emily Bowie (543704)

“…We previously showed that TTBK2 is a key regulator of the assembly of primary cilia <i>in vivo</i>. …”

Localization of key HH signaling proteins is impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress by Béatrice Chambraud (3371201)

“…In this study, we demonstrate that FKBP4 decrease in a human neuronal cell line (SH-SY5Y) and in dorsal root ganglion (DRG) neurons from human MAPT^P301S transgenic mice affected the function of the autophagy-lysosomal system under MAPT induced proteotoxic stress conditions. …”

Ba₂NaClP₂O₇: Unprecedented Phase Matchability Induced by Symmetry Breaking and Its Unique Fresnoite-Type Structure by Jie Chen (5892)

“…Herein, we report a unique Ba₂NaClP₂O₇ representing the first phase-matchable example of the fresnoite family, which exhibits excellent NLO properties, including short absorption edge (<176 nm, ca. 7.0 eV), strong second-harmonic generations at the incident lasers of 850–1110 nm (obv. 0.9–1.3 × KDP; cal. …”

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease by Christine M. LaPash Daniels (796881)

“…Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. …”