Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Experimental and <i>ab Initio</i> Study of Catena(bis(μ₂‑iodo)-6-methylquinoline-copper(I)) under Pressure: Synthesis, Crystal Structure, Electronic, and Luminescence Pr... by Amagoia Aguirrechu-Comerón (2882069)

“…In particular, the band gap decreases slowly with pressure in a quadratic way with d<i>E</i>_<i>g</i>/d<i>P</i> = −0.011 eV/GPa and d²<i>E</i>_<i>g</i>/d<i>P</i>² = 0.001 eV/GPa².…”

Filamentation induced by DTPA is associated with a decrease in Nrg1 protein level, and requires the cAMP-PKA pathway and the kinase Sok1. by Elizabeth J. Polvi (3163500)

Adding tsetse control to medical activities contributes to decreasing transmission of sleeping sickness in the Mandoul focus (Chad) by Mahamat Hissene Mahamat (4282306)

“…Pre-2014, control of HAT relied solely on case detection and treatment, which lead to a gradual decrease in the number of cases of HAT due to annual screening of the population.…”

Image_1_EEG 40 Hz Coherence Decreases in REM Sleep and Ketamine Model of Psychosis.TIF by Santiago Castro-Zaballa (6238823)

“…On the contrary, gamma power was relatively high under ketamine, and similar to QW and REM sleep. We conclude that functional interactions between cortical areas in the gamma frequency band decrease in both experimental models of psychosis. …”

Dimerization of [Fe^III(bpy)₃]³⁺ in Aqueous Solutions: Elucidating a Mechanism Based on Historical Proposals, Electrochemical Data, and Computationa... by Nicolas E. Holubowitch (9254254)

“…Despite these favorable characteristics, its oxidized Fe­(III) form undergoes dimerization to form μ-O-[Fe^III(bpy)₂(H₂O)]₂⁴⁺, leading to a dramatic ∼0.7 V decrease during battery discharge. …”

Decrease in vRNA in brain during antiretroviral therapy. by Sonny R. Elizaldi (9684796)

Data_Sheet_1_Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma.docx by Vanessa M. Beutgen (6432671)

FOXO1-mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys by Mengru Zeng (10119544)

All TEAM Occupancy from Tropical mammal functional diversity increases with productivity but decreases with anthropogenic disturbance by Daniel Gorczynski (10093617)

MICROPLASTICS INCREASE SOIL PH AND DECREASE MICROBIAL ACTIVITIES AS A FUNCTION OF MICROPLASTIC SHAPE, POLYMER TYPE, AND EXPOSURE TIME- original data.xlsx by Tingting Zhao (10756023)

Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats by DHÉBORA M. DALL’IGNA (10365522)

Spreading Electron Density Thin: Increasing the Chromophore Size in Polyaromatic Wires Decreases Interchromophoric Electronic Coupling by Mohammad M. Hossain (420598)

Organometallic Synthesis of 2,3,6,7-Tetrasubstituted 1,8-Bis(dimethylamino)naphthalenes for Investigation of the Double Buttressing Effect in Proton Sponges by Andrey V. Marchenko (14193336)

“…Using X-ray diffraction and basicity measurements, we showed that due to the high conformational mobility of the methoxy groups, the most striking manifestations of double BE are the strong planarization of <i>peri</i>-NMe₂ groups and a significant decrease in basicity, while the length and the other properties of the intramolecular NHN hydrogen bond in the corresponding protonated species undergo minor changes.…”

Excessive free fatty acids sensing in pituitary lactotrophs elicits liver steatosis by decreasing prolactin levels by Xinlu Ji (12433917)

The Millennium Ecosystem Assessment examined how each scenario would increase or decrease material well-being, health, security, social relations, and freedom of choice and action by Richard Dahl (12127)

Supplementary Material for: Maternal Stress During Pregnancy Is Associated with Decreased Cortisol and Cortisone Levels in Neonatal Hair by vanderVoorn B. (6076475)

Supplementary Material for: Occurrence of Cerebrovascular Diseases Decreased after the Great East Japan Earthquake and Tsunami of 2011 by Omama S. (9473168)