Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome. by Thirumal Kumar, D

“…In the simulations, we observed decreased deviation and fluctuations in native NOD2, whereas decreased compactness and inter- and intramolecular hydrogen bonds were observed in the W490L mutant. …”
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The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes. by Al-Asmakh, Maha

“…The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. …”
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Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling by Ibrahim, Khadega

“…Compared to RSG group, the combined treatment group stimulates osteoblastogenesis, as evidenced by increased mineralization and upregulation of osteogenic markers OPN and RUNX2 and inhibits adipogenesis in osteogenic media as showed by decreased lipid content and downregulation of adipogenic markers FABP4, LPL and adipsin. …”
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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress by Fatima, Munazza T

“…We found that SESN2 silencing, though did not specifically induce ER stress, it aggravated the effects of thapsigargin-induced ER stress on oxidative stress and cell survival. …”
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Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach. by Thirumal Kumar, D

“…From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex. …”
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Micromodel Study on Colloid Retention and Mobilization under different Geo-Chemical Conditions during Single and Two-Phase Flow by Nishad, Safna

“…Micromodels are analogs to porous media that allow the real-time visualization of pore-scale processes that occur at highly controllable physio-chemical conditions in the laboratory scale. In this thesis, we used a glass micromodel with representative geometry to observe the pore-scale mechanisms during colloid retention and mobilization experiments in a saturated and unsaturated porous media. …”
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes by Abushanab, Dina

“…AimsInsufficient risk factor control can lead to a loss of millions of productivity-adjusted life years (PALYs). We aimed to assess the productivity burden of cardiovascular disease (CVD) in type 2 diabetes (T2D) and examine the potential advantages of enhancing the control of modifiable CVD risk factors in Qatar. …”
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Aqueous Extract Of Origanum Syriacum Inhibits Proliferation, Migration, Adhesion As Well As Erk1/2 Phosphorylation In Aggressive Breast Cancer by Al Kahlout, Amal

“…Moreover, preliminary results indicate that OSE decreased ERK1/2 phosphorylation in MDA-MB-231 cells. …”
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. by Akhtar, Sabah

“…SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. In addition, it also upregulates pro-apoptotic protein, Bax. …”
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Characterization of polysulfone/diisopropylamine 1-alkyl-3-methylimidazolium ionic liquid membranes: high pressure gas separation applications by Khraisheh M.

“…Thermogravimetric analysis measurement (TGA), differential scanning calorimeter (DSC), dynamic mechanical analysis, and the tensile properties of the membranes are studied in order to optimize the efficiency of separating CO2 from CO2/N2 mixture and CO2/CH4. TGA showed that pure PSF is a highly thermostable polymer, of which the 5% weight loss temperature is above 150 C. …”
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A Model For A Narrow-Cut Fractionating Column by Farag, Hassan A.

“…A mathematical model was developed to simulate the operation of a narrow-cut fractionating column. …”
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Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath, Chethan

“…Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(e)-(carboxymethyl)lysine (CML) found to be predominantly higher in the diabetic population. We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2- related-factor-2 (Nrf2)-dependent pathway. …”
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Effect of zirconia nanotube coating on the hydrophilicity and mechanochemical behavior of zirconium for biomedical applications by Nezhad, Erfan Zal

“…Zirconium has attracted considerable attention in the biomedical field owing to its biocompatibility and desirable tribological and mechanical properties. In this study, we anodized pure zirconium in an ammonium fluoride and ethylene glycol electrolyte, which produced a coating of ZrO2 nanotubes (NTs). …”
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Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity by Sampath, Chethan

“…Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would mitigate AGEs formation via activating the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway in a mouse model of high fat diet-induced obesity. …”
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Sulforaphane reduces obesity by reversing leptin resistance. by Çakır, Işın

“…Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia. …”
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Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells by Kuttikrishnan, Shilpa

“…Thiostrepton led downregulation of FoxM1 accompanied by decreased expression of Aurora kinase A, B, matrix metalloproteinases, and oncogene SKP2 as well as MTH1. …”
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Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model. by Al-Kandari, Halema

“…Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen (H₂RGOTi)-reduced graphene oxide/TiO₂ semiconductor photocatalysts recently employed in AOPs. …”
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Angiotensin receptor blocker-neprilysin inhibitor for heart failure with reduced ejection fraction by Nasrallah, Dima

“…We also discuss the evidence showing the added benefit resulting from combining ARNIs with a sodium-glucose cotransporter-2 (SGLT-2) inhibitor. …”
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Signaling pathways activated by PACAP in MCF-7 breast cancer cells by Zibara, Kazem

“…On the other hand, PACAP induced calcium release, which was decreased by pretreatment with PLC inhibitor. Finally, PACAP stimulation promoted apoptosis by increasing Bax and decreasing Bcl2 expression. …”
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Convection In A Rotating Fluid Over A Sloping Bottom, With Application To The Arabian Gulf by Al Hajri, Khalid R.

“…The results of the two dimensional model are presented herein. These results include (i) a detailed description of the evapora-tive-convective adjustment process; (ii) a measure of the convective length scale and vertical velocity; (iii) an assessment of the relative strengths of the buoyancy induced geostrophic current in the alongshore direction and the direct wind induced velocities; (iv) an assessment of the effect of wind on the density structures and (v) an analogy between the forcing by diffusive buoyant source and advective buoyant source.…”
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