ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota by Sup Kim (6371849)

“…</p> <p><b>Abbreviations:</b> ABX, antibotics; AMPK, AMP-activated protein kinase; ATP5A1, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1; BECN1, beclin1, autophagy related, CCL, C-C motif chemokine ligand; CD, Crohn disease; CLDN, claudin; COX4I1, cytochrome c oxidase subunit 4I1; cKO, conditional knockout; cWT, conditional wild-type; CXCL, C-X-C motif chemokine ligand; DAI, disease activity index; DSS, dextran sodium sulfate; EGFP, enhanced green fluorescent protein; ESRR, estrogen related receptor; ESRRA, estrogen related receptor alpha; Esrra+/+, Esrra wild type; esrra–/-, esrra homozygous knockout; FMT, fecal microbiota transplantation; GABARAP, gamma-aminobutyric acid receptor associated protein; GSEA, gene set enrichment analysis; IBD, inflammatory bowel disease; IL, interleukin; KO, knockout; LAMP1, lysosomal-associated membrane protein 1; LCN2, lipocalin 2; LEfSe, linear discriminant analysis (LDA) effect size; LPS, lipopolysachharide; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; NDUFAB1, NADH: ubiquinone oxidoreductase subunit AB1; OCLN, occludin; OUT, operational taxonomic unit; OXPHOS, oxidative phosphorylation; PCoA, principal coordinate analysis; PPARGC1A, PPARG coactiva- tor 1 alpha; PRKAA, 5’-AMP-activated protein kinase catalytic subunit alpha; PTGS2/COX2, prostaglandin-endoperoxide synthase 2; RAB7, member RAS oncogene family; SDHB, succinate dehydrogenase complex, subunit B, iron sulfur (Ip); SQSTM1/p62, sequestosome 1; S100A9, S100 calcium binding protein A9 (calgranulin B); TCA, tricarboxylic acid; TFEB, transcription factor EB; TNF, tumor necrosis factor; UC, ulcerative colitis; UCP2, uncoupling protein 2 (mitochondrial, proton carrier); UQCRC1, ubiquinol-cytochrome c reductase core protein 1; UVRAG, UV radiation resistance associated gene; Vil1, villin; VPS11, VPS11, CORVET/HOPS core sub-unit; WT, wild type.…”

Clinicopathologic implication of meticulous pathologic examination of regional lymph nodes in gastric cancer patients by Jiwon Koh (3176034)

“…</p><p>Methods</p><p>Four cohorts with a total of 2,309 gastric cancer patients were enrolled. …”

Evaluation of diabetic patients after three month use of continuous subcutaneous insulin infusion, dispensed by a protocolled form at outpatient reference clinic of Taguatinga Regi... by Leonardo Garcia Miranda (6151652)

“…Results The entire sample (ECO) and 3 subgroups (group 1 – A1c decrease, group 2 – A1c stable, and group 3 – A1c increase), stratified according to a ≥ 0.5% change in A1c, were analyzed. …”

Allelopathic Effect of Some Associated Weeds of Wheat on Germinability and Biomass Production of Wheat Seedlings by A. ZOHAIB (4748637)

“…The present study was conducted to investigate the allelopathic effect of water soluble phenolics of weeds associated with wheat crop (Vicia sativa, Trigonella polycerata, Lathyrus aphaca, Medicago polymorpha, Melilotus indica) on germinability and biomass production of wheat seedlings by using their water extracts at 2.5% (w/v) and 5% (w/v) concentrations and residues of the same weeds with 0, 15 and 30 d decomposition periods at 2% (w/w) concentration. …”

Allelopathic Effect of Some Associated Weeds of Wheat on Germinability and Biomass Production of Wheat Seedlings by A. ZOHAIB (4748637)

“…The present study was conducted to investigate the allelopathic effect of water soluble phenolics of weeds associated with wheat crop (Vicia sativa, Trigonella polycerata, Lathyrus aphaca, Medicago polymorpha, Melilotus indica) on germinability and biomass production of wheat seedlings by using their water extracts at 2.5% (w/v) and 5% (w/v) concentrations and residues of the same weeds with 0, 15 and 30 d decomposition periods at 2% (w/w) concentration. …”

DataSheet_1_A first-in-human, open-label, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor ac... by Zhiyu Huang (638377)

“…Background<p>QL1604 is a humanized immunoglobulin G4 monoclonal antibody against programmed cell death protein 1. …”

DataSheet2_Acceptance of Public Health Measures During the COVID-19 Pandemic: A Cross-Sectional Study of the Swiss Population’s Beliefs, Attitudes, Trust, and Information-Seeking B... by Maddalena Fiordelli (7529555)

“…</p><p>Methods: In January 2022, we conducted a cross-sectional survey of the Swiss population (N = 2,587). …”

DataSheet_1_Integrative network analysis revealed the molecular function of folic acid on immunological enhancement in a sheep model.docx by Bing Wang (126120)

“…Meanwhile, folic acid increased the abundances of S100A12 and IRF6 but decreased TMEM25 in the liver. …”

Image_1_Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.tif by Jie He (132999)

“…CPAP treatment can significantly decrease serum/plasma HCY levels in patients with OSAHS. …”

Image_3_Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.tif by Jie He (132999)

“…CPAP treatment can significantly decrease serum/plasma HCY levels in patients with OSAHS. …”

Image_2_Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.tif by Jie He (132999)

“…CPAP treatment can significantly decrease serum/plasma HCY levels in patients with OSAHS. …”

Table_1_Age and estimated glomerular filtration rate in Chinese older adults: a cohort study from 2014 to 2020.docx by Ying Jiang (5910)

“…For every 1-year increase in age, women’s eGFR decreased by 1.06 mL/min/1.73 m² and men’s by 0.91 mL/min/1.73 m². …”

Image_1_A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.TIF by Kaijie Ma (6065156)

“…Voltage-clamp recordings revealed that the sodium current densities were significantly increased in the pyramidal neurons of male BDNF^+/Met mice, which were mediated by increased transcriptional level of Scn2a encoding sodium channel Na_V 1.2. …”

Data_Sheet_2_Integrated Metabolome and Transcriptome Analysis of Fruit Flavor and Carotenoids Biosynthesis Differences Between Mature-Green and Tree-Ripe of cv. “Golden Phoenix” Ma... by Lei Peng (260321)

“…The analysis of carotenoid contents identified 68 carotenoids and we report for the first-time significant contents of zeaxanthin palmitate and (E/Z)-phytoene in mango fruits. α-carotene was a further major contributor to carotene contents with lesser contributions from 5,6epoxy-lutein-caprate-palmitate, β-carotene, lutein oleate, and β-cryptoxanthin. …”

Table 1_Trend of electroconvulsive therapy use and its relationships with clinical characteristics from a large psychiatric center in China.doc by Wei Li (7081)

“…Compared with that in 2015 (13.2%), ECT use decreased annually from 2016 (12.4%) to 2019 (9.6%), especially in 2020 (5.7%), given the impact of the COVID-19 pandemic in China.…”

A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Trisha Tucholski (3992264)

“…Notably, within a 5 <i>m</i>/<i>z</i> window, we obtained baseline isotopic resolution for 6 distinct large proteoforms (30–50 kDa). …”

Table_1_Rational medication management mode and its implementation effect for the elderly with multimorbidity: A prospective cohort study in China.DOCX by Qi Tang (351973)

“…Given these situations, we constructed a Rational Medication Management Mode based on family physician service, carried out an empirical research and evaluated the implementation effect.…”

Survival outcomes post percutaneous coronary intervention: Why the hype about stent type? Lessons from a healthcare system in India by Bhanu Duggal (5279009)

“…Increased use of DES after 2015 (following establishment of a price cap on DESs) was associated with a sharp decrease in adjusted hazard ratios of DESs versus BMSs (from 0.94 in 2013 to 0.58 in 2016), suggesting that high price was limiting DES use in some high-risk patients. …”

Image_2_Intra-Tumoral Activation of Endosomal TLR Pathways Reveals a Distinct Role for TLR3 Agonist Dependent Type-1 Interferons in Shaping the Tumor Immune Microenvironment.tiff by Graham Thomas (3250164)

“…A biased type-1 interferon signature is elicited upon TLR3 agonist treatment as opposed to a type-2 interferon signature with TLR9 agonists. TLR3 stimulation was associated with increased macrophage antigen presentation gene expression and decreased expression of PD-L1 and the inhibitory receptors Pirb and Pilra on infiltrating monocytes. …”

DataSheet2_Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1.docx by Lu Xiao-Rong (11754572)

“…Aspirin eugenol ester (AEE) is a novel synthetic compound which is made up of two chemical structural units from aspirin and eugenol. …”