Image_2_Triple-negative and Her2-positive breast cancer in women aged 70 and over: prognostic impact of age according to treatment.tiff by Gilles Houvenaeghel (230596)

“…We report herein the results of a multicenter retrospective study analyzing the prognostic impact of age according to treatment delivered in TN and Her2-positive BC patients of 70 years or older, including comparison by age groups.…”

Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in <i>Drosophila</i> Sensory Neurons by Tzu Lin (822560)

“…The redistribution of Spn-F from puncta in pupal neurons requires the phosphorylation of Spn-F by Ik2 kinase to decrease Spn-F self-association, and depends on the function of microtubule motor dynein complex. …”

image5_Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis–Infected Monocyte-Derived Macrophages.jpeg by Ousman Tamgue (6477188)

“…Using the CFU count method, we found that triptolide decreased the intracellular growth of Mtb HN878. …”

S252W mutation affected Wnt signaling in osteogenically differentiating BMSCs. by Li Zhang (8200)

“…<p>(A) Cluster analysis of a microarray data revealed that Wnt pathway antagonists SRRP1, SFRP2, and SFRP4 were up-regulated 3.8 fold, 2.5 fold, and 2.9 fold in mutant BMSCs, respectively (<i>n</i> = 3). …”

DataSheet_1_Direct Effects of Glyphosate on In Vitro T Helper Cell Differentiation and Cytokine Production.docx by Ambra Maddalon (12186914)

“…PBMC were expose to G and stimulated with PMA/ionomycin, T helper (Th) cell differentiation and cytokine production were assessed by flow cytometry and enzyme-linked immunosorbent assay, respectively. A reduction of Th1/Th2 ratio, mainly due to a decrease in Th1 cells, was observed following G exposure. …”

Transcriptomes of NS1-S1 and NS1^mTAD2-S1 cell lines treated with or without Dox. by Peng Xu (17962)

“…<p>(A) Heatmap of 1,770 genes differentially expressed between NS1-S1 and NS1^mTAD2-S1 cell lines (Gene set 5). …”

Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor. by Padmanabhan, Regina

“…Precisely, several questions regarding the right combination of drugs, drug modality, and effective dose recommendations pertaining to the use of ICB-based therapy for HER2+ patients remain unanswered. In this study, we use a mathematical modeling-based approach to quantify the growth inhibition of HER2+ breast cancer (BC) cell colonies (ZR75) when treated with anti-HER2; trastuzumab (TZ) and anti-PD-1/PD-L1 (BMS-202) agents. …”
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Image_2_The Expression Patterns of FAM83H and PANX2 Are Associated With Shorter Survival of Clear Cell Renal Cell Carcinoma Patients.TIF by Kyoung Min Kim (436671)

“…Therefore, we evaluated the clinicopathological significance of the immunohistochemical expression of FAM83H and PANX2 in 199 CCRCC patients. …”

CX3CR1^-/- impaired left ventricular function in Coxsackievirus B3-infected mice. by Irene Müller (4351060)

DataSheet2_Azilsartan Suppresses Osteoclastogenesis and Ameliorates Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species Production and Activating Nrf2 Signaling.... by Bin Pan (742525)

“…Furthermore, azilsartan reduced RANKL-induced ROS production by increasing the expression of nuclear factor erythroid 2-related factor 2 (Nrf2). Mechanistically, azilsartan inhibited the activation of MAPK/NF-κB signaling pathways, while Nrf2 silencing reversed the inhibitory effect of azilsartan on MAPK/NF-κB signaling pathways. …”

Alterations in cell ultrastructure examined by TEM during the addition of G-CSF (100 nM) to HBVECs for 12 h before and throughout the combination stimulus. by Jingjing Su (718308)

“…<p>(A) The intact cell ultrastructure under normal condition. …”

Effect of the substitution of residue F595 in the JH2 αC helix on the constitutive activity of JAK2 V617F and on the ligand-induced activation of JAK2 wild-type measured by lucifer... by Alexandra Dusa (247246)

“…<p>(A) Mutation of F595 to some residues induces up to an 86% decrease in the constitutive activity of JAK2 V617F, depending on the particular substitution, while mutation of F595 to aromatic residues rescues the constitutive activity of JAK2 V617F. …”

Image_2_Integrating Mortality Risk and the Adaptiveness of Hibernation.pdf by Théo Constant (9109544)

“…Hibernation is considered a seasonal adaptation to prolonged periods of food shortage and cold. …”

Table_2_Integrating Mortality Risk and the Adaptiveness of Hibernation.docx by Théo Constant (9109544)

“…Hibernation is considered a seasonal adaptation to prolonged periods of food shortage and cold. …”

Supplementary Material for: Prostaglandin E₂ Regulates Activation of Mouse Peritoneal Macrophages by <b><i>Staphylococcus aureus</i></b> through Toll-Like Receptor 2, To... by Wu J. (3278256)

“…We determined whether <i>Staphylococcus aureus</i> lipoproteins are essential for inducing PGE₂ secretion by immune cells and whether pattern recognition receptors mediate this process. …”

DataSheet1_Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload.PDF by Nan Zhang (46264)

“…</p><p>Methods and results: Sesn2 expression was significantly increased in mice hearts at 2 and 4 weeks after aortic banding (AB) surgery, but decreased to 60–70% of the baseline at 8 weeks. …”

Plasminogen has a very weak inhibitory effect on complement deposition on platelets. by Satu Hyvärinen (833817)

“…Shown is a representative histogram of four. <b>B</b>: A representative histogram showing very slight decrease in C3-fragment deposition on platelets in serum due to addition of plasminogen. …”

DataSheet1_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”

DataSheet2_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”

DataSheet3_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”