<i>In vivo</i> efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy by Jianxun Wang (290485)

“…We obtained echocardiographs of SHP2^Y279C/+ and wildtype (SHP2^+/+) littermates, either in the presence or absence of ARQ 092 at 12, 14, and 16 weeks of age. …”

Baseline characteristics of the participants. by Xiaozhu Shen (16363326)

“…Except for 28 patients excluded before randomization and 14 patients who did not meet the criteria or dropped out or lost to follow-up during the trial, the remaining 38 patients (intervention group: 17, control group: 21) had well-balanced baseline features. In this trial, we found that plasma BNP levels (<i>P</i> = 0.003) decreased and NEP levels (<i>P</i> = 0.006) increased in enrolled patients after treatment with sacubitril/valsartan. …”

Baseline levels of indicators before medication. by Xiaozhu Shen (16363326)

“…Except for 28 patients excluded before randomization and 14 patients who did not meet the criteria or dropped out or lost to follow-up during the trial, the remaining 38 patients (intervention group: 17, control group: 21) had well-balanced baseline features. In this trial, we found that plasma BNP levels (<i>P</i> = 0.003) decreased and NEP levels (<i>P</i> = 0.006) increased in enrolled patients after treatment with sacubitril/valsartan. …”

Fluctuations in systolic blood pressure. by Xiaozhu Shen (16363326)

“…Except for 28 patients excluded before randomization and 14 patients who did not meet the criteria or dropped out or lost to follow-up during the trial, the remaining 38 patients (intervention group: 17, control group: 21) had well-balanced baseline features. In this trial, we found that plasma BNP levels (<i>P</i> = 0.003) decreased and NEP levels (<i>P</i> = 0.006) increased in enrolled patients after treatment with sacubitril/valsartan. …”

Monitoring of blood pressure. by Xiaozhu Shen (16363326)

“…Except for 28 patients excluded before randomization and 14 patients who did not meet the criteria or dropped out or lost to follow-up during the trial, the remaining 38 patients (intervention group: 17, control group: 21) had well-balanced baseline features. In this trial, we found that plasma BNP levels (<i>P</i> = 0.003) decreased and NEP levels (<i>P</i> = 0.006) increased in enrolled patients after treatment with sacubitril/valsartan. …”

Flow diagram of included and excluded patients. by Xiaozhu Shen (16363326)

“…Except for 28 patients excluded before randomization and 14 patients who did not meet the criteria or dropped out or lost to follow-up during the trial, the remaining 38 patients (intervention group: 17, control group: 21) had well-balanced baseline features. In this trial, we found that plasma BNP levels (<i>P</i> = 0.003) decreased and NEP levels (<i>P</i> = 0.006) increased in enrolled patients after treatment with sacubitril/valsartan. …”

Image_1_Local Mucosal CO2 but Not O2 Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock.tif by Stefan Hof (12472464)

“…Local hypercapnia ameliorated the decrease of μHbO₂ from 78 ± 4% to 51 ± 8%. …”

Table_1_Local Mucosal CO2 but Not O2 Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock.DOCX by Stefan Hof (12472464)

“…Local hypercapnia ameliorated the decrease of μHbO₂ from 78 ± 4% to 51 ± 8%. …”

Table_3_Local Mucosal CO2 but Not O2 Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock.DOCX by Stefan Hof (12472464)

“…Local hypercapnia ameliorated the decrease of μHbO₂ from 78 ± 4% to 51 ± 8%. …”

Nrf2 intervention into the TGF-β1/Smad signalling pathway. by Vincenzo Prestigiacomo (4217353)

“…Thus, HSC cells exhibit a quiescent phenotype. Panel B, Nrf2 knockdown: we have found out that Nrf2 knockdown, with a consequent decrease of its target genes, induces stellate cells activation. …”

Unidirectional Droplet Propulsion onto Gradient Brushes without External Energy Supply by Russell Kajouri (14594307)

Site Dependency of the High Conductivity of Ga₂In₆Sn₂O₁₆: The Role of the 7‑Coordinate Site by Karl Rickert (1467796)

“…To investigate the potential impact of these alternative sites, we partially replace the Sn in Ga₂In₆Sn₂O₁₆ with Ti, Zr, or Hf and use a combined approach of density functional theory-based calculations, X-ray diffraction, and neutron diffraction to establish that the substitution occurs preferentially on the 7-coordinate site. …”

Table 1_Revising cancer incidence in a Central European country: a Hungarian nationwide study between 2011–2019 based on a health insurance fund database.xlsx by Zoltán Kiss (5570003)

“…All-site cancer incidence showed a mean annual decrease of 1.9% (95% CI: 2.4%-1.4%) in men and 1.0% (95% CI:1.42%-0.66%) in women, parallel to mortality trends (-1.6% in males and -0.6% in females; ESP 2013). …”

Image_2_Effects of high night temperature on soybean yield and compositions.jpeg by Lin Yang (45852)

“…Which could be another important reason for the decrease of sucrose. These findings provided a theoretical basis for enhancing the tolerance of soybean to high night temperature.…”

Image_2_Effects of high night temperature on soybean yield and compositions.jpeg by Lin Yang (45852)

“…Which could be another important reason for the decrease of sucrose. These findings provided a theoretical basis for enhancing the tolerance of soybean to high night temperature.…”

Table_1_Causal relationship between dietary intake and IgA nephropathy: a Mendelian randomization study.xls by Yaping Li (399717)

“…Based on publicly available genome-wide association study (GWAS) data, we conducted a two-sample Mendelian randomization (MR) analysis to assess the causal association between 26 dietary exposures and IgAN.…”

Process of model building. by Gazi Md. Salahuddin Mamun (13905678)

“…Developing a clinical prediction rule for treatment failure may allow early identification of high-risk patients and timely intervention to decrease mortality. We used data from two separate studies conducted at the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) to derive and externally validate a clinical prediction rule for treatment failure of children hospitalized with severe pneumonia. …”

De-identified external validation dataset. by Gazi Md. Salahuddin Mamun (13905678)

“…Developing a clinical prediction rule for treatment failure may allow early identification of high-risk patients and timely intervention to decrease mortality. We used data from two separate studies conducted at the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) to derive and externally validate a clinical prediction rule for treatment failure of children hospitalized with severe pneumonia. …”

Partial dependency plots of the top 6 predictors. by Gazi Md. Salahuddin Mamun (13905678)

“…Developing a clinical prediction rule for treatment failure may allow early identification of high-risk patients and timely intervention to decrease mortality. We used data from two separate studies conducted at the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) to derive and externally validate a clinical prediction rule for treatment failure of children hospitalized with severe pneumonia. …”

De-identified derivation dataset. by Gazi Md. Salahuddin Mamun (13905678)

“…Developing a clinical prediction rule for treatment failure may allow early identification of high-risk patients and timely intervention to decrease mortality. We used data from two separate studies conducted at the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) to derive and externally validate a clinical prediction rule for treatment failure of children hospitalized with severe pneumonia. …”