Image5_Knockout of C1q/tumor necrosis factor-related protein-9 aggravates cardiac fibrosis in diabetic mice by regulating YAP-mediated autophagy.tif by Shiyan Ruan (18986591)

“…However, whether CTRP9 affects diabetic myocardial fibrosis and its underlying mechanisms remains unclear.</p>Methods<p>We developed a type 1 diabetes (T1DM) model in CTRP9-KO mice via streptozotocin (STZ) induction to examine cardiac function, histopathology, fibrosis extent, Yes-associated protein (YAP) expression, and the expression of markers for autophagy such LC3-II and p62. …”

Table_2_Communication of Diagnosis of Infertility: A Systematic Review.DOC by Laura Mosconi (10325153)

“…The main addressed aspects concerning the communication of the infertility diagnosis were the following: (i) the value that patients give to healthcare professionals' communication skills; (ii) the importance of giving clear information on diagnostic procedures and treatments in order to decrease patients' anxiety; and (iii) the importance of involving both partners.…”

Image 2_PLK1 inhibition impairs erythroid differentiation.jpeg by Peijun Jia (11334594)

“…More specifically, PLK1 inhibition impaired the differentiation and erythroid commitment of hematopoietic stem cells in the bone marrow, resulting in abnormal accumulation of BFU-E cells and reduced proliferation and differentiation of CFU-E, and a decrease in the number of terminal erythrocytes. Mechanistically, PLK1 inhibitors primarily induce apoptosis in erythroid cells by reducing Mitochondrial membrane potential and arresting the cell cycle at the G2/M phase. …”

PATL2 regulated the apoptosis of ovarian granulosa cells in patients with PCOS by Shao-Lan Peng (10823499)

“…We found that PATL2 was also expressed in human ovarian GCs, suggesting that PATL2 may be involved in the regulation of related biological events in GCs. …”

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia by Beomsue Kim (172914)

“…Using Lrrk2 knockdown (Lrrk2-KD) murine microglia prepared by lentiviral-mediated transfer of Lrrk2-specific small inhibitory hairpin RNA (shRNA), we found that Lrrk2 deficiency attenuated lipopolysaccharide (LPS)-induced mRNA and/or protein expression of inducible nitric oxide synthase, TNF-α, IL-1β and IL-6. …”

Table_2_Analysis of LINE1 Retrotransposons in Huntington’s Disease.XLSX by Lavinia Floreani (11946644)

“…The length of the expanded CAG tract is related to age at disease onset, with longer repeats leading to earlier onset. Here we carried out bioinformatic analysis of public RNA-seq data of a panel of HD mouse models showing that a decrease of L1 RNA expression recapitulates two hallmarks of the disease: it correlates to CAG repeat length and it occurs in the striatum, the site of neurodegeneration. …”

Relationship between task-evoked activation and differences between task-based and resting state FC. by Paulina Kieliba (6577226)

Associations of <i>ABHD2</i> Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population by Li Liu (75607)

“…Here, we evaluated genetic variation in the <i>ABHD2</i> gene in a Chinese Han population of 286 COPD patients and 326 control subjects. …”

<i>Cobl</i> KO mice fail to show repair of the dendritic arborization defects caused by MCAO in both layer II/III and layer V neurons of the ipsilateral hemisphere. by Yuanyuan Ji (455424)

“…Note that dendritic branching points (<b>E</b>), dendritic terminal points (<b>F</b>), total dendritic tree length (<b>G</b>), and Sholl intersections (<b>H-J</b>) were all decreased at 24 hours after MCAO and that, in contrast to WT animals (<b><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001399#pbio.3001399.g005" target="_blank">Fig 5</a></b>), none of these phenotypical parameters recovered during the days after MCAO in <i>Cobl</i> KO mice. …”

Data_Sheet_1_Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered.pdf by Alex B. Speers (11845991)

“…</p>Results<p>CAW decreased cortical Aβ plaque burden in female 5xFAD mice administered CAW in the drinking water but had no effect on Aβ plaques in other treatment groups. …”

table_1_A Beneficial Effect of Low-Dose Aspirin in a Murine Model of Active Tuberculosis.docx by Vera Marie Kroesen (5128211)

“…Results from the immunological studies suggest the anti-inflammatory action of LDA at both a local and a systemic level. Our results showed a systemic decrease in neutrophilic recruitment, decreased levels of acute-phase reaction cytokines (IL-6, IL-1β, and TNF-α) at late stage and a delay in the decrease in T cell response (in terms of IFN-γ, IL-2, and IL-10 serum levels) that occurs during the course of Mycobacterium tuberculosis infection. …”

Table2_SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells.XLSX by Rekha Tripathi (9092534)

“…Metabolomic data showed decreased cholesterol levels, changed fatty acid synthesis, and altered levels of fumaric acid, citrate, 2-oxoglutarate and succinate in the TCA cycle. …”

Image_2_Induced Pluripotent Stem Cells Derived From Two Idiopathic Azoospermia Patients Display Compromised Differentiation Potential for Primordial Germ Cell Fate.TIF by Fang Fang (38179)

“…In vitro generation of patient-specific induced pluripotent stem cells (iPSCs) is an effective approach for exploring the mechanisms of human disease. Here, we established iPSCs from two patients with idiopathic NOA and differentiated them into primordial germ cell–like cells (PGCLCs) in vitro. …”

Image_2_Induced Pluripotent Stem Cells Derived From Two Idiopathic Azoospermia Patients Display Compromised Differentiation Potential for Primordial Germ Cell Fate.TIF by Fang Fang (38179)

“…In vitro generation of patient-specific induced pluripotent stem cells (iPSCs) is an effective approach for exploring the mechanisms of human disease. Here, we established iPSCs from two patients with idiopathic NOA and differentiated them into primordial germ cell–like cells (PGCLCs) in vitro. …”

Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of <em>Drosophila melanogaster</em> by Ning Wang (108353)

“…In this study, we investigated the role of Tap42, a common regulatory subunit for all three PP2A family members, in the development of <em>Drosophila</em> m<em>elanogaster</em> wing imaginal discs. …”

Video 2_Spatiotemporal variability of turbulent fluxes in snow-covered mountain terrain.mp4 by Rainette Engbers (22611641)

“…Although these processes are subject to great spatial and temporal variability, especially in complex terrain, measurements of heat, moisture, and momentum fluxes are almost exclusively point observations. Numerical modeling offers a means to assess the spatial variability of fluxes and evaluate the representativeness of point observations. …”

Data Sheet 2_Spatiotemporal variability of turbulent fluxes in snow-covered mountain terrain.pdf by Rainette Engbers (22611641)

“…Although these processes are subject to great spatial and temporal variability, especially in complex terrain, measurements of heat, moisture, and momentum fluxes are almost exclusively point observations. Numerical modeling offers a means to assess the spatial variability of fluxes and evaluate the representativeness of point observations. …”

Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer... by Chenqu Wu (16842903)

“…<p><b>Background:</b> Cancer-associated fibroblast (CAF) exosomal miRNAs have gradually a hot spot in cancer therapy. This study mainly explores the effect of CAF-derived exosomal miR-29b-1-5p on gastric cancer (GC) cells.…”

Ablation results. by Gang Xu (219455)

“…Evaluation on the ScanNetV2 multi-view 3D object detection dataset demonstrates that ImVoxelGNet achieves a performance improvement of up to 2.2% in mean average precision (mAP). …”

Lumican modulates adipocyte function in obesity-associated type 2 diabetes by Clarissa Strieder-Barboza (4662910)

“…<p>Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. …”