Image_2_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Image_2_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Image_2_Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer.tif by Yanhong Pan (3271245)

“…This was considered to be due to inhibiting the activity of pyruvate kinase (PK) and further blocking pyruvate kinase M2 (PKM2) translocation in nucleus. Fructose-1,6-bisphosphate (FBP) and L-cysteine can significantly reverse cantharidin inhibition on breast cancer cell migration, invasion, and PKM2 translocation. …”

DataSheet2_(+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway.xlsx by Yiyuan Xi (3776182)

“…<p>An overload of hepatic fatty acids, such as oleic acid is a key trigger of non-alcoholic fatty liver disease (NAFLD). Here, we investigated whether Artemisia frigida, a valuable traditional medicine used to treat various diseases, could mitigate OA-induced lipid accumulation in HepG2 cells. …”

Table2_Asthmatic lung fibroblasts promote type 2 immune responses via endoplasmic reticulum stress response dependent thymic stromal lymphopoietin secretion.pdf by Li Y. Drake (10892585)

“…Endoplasmic reticulum (ER) stress and unfolded protein responses (UPR) play important roles in asthma, but their functional roles are still under investigation. In this study, we investigated TNFα-induced cytokine production in primary lung fibroblasts from asthmatic vs. non-asthmatic human subjects, and downstream effects on type 2 immune responses. …”

Table_1_Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway.DOCX by Yun Yang (417125)

“…Cusson possesses potent anti-tumor activity. Here, we for the first time investigated the anti-tumor activity of trastuzumab in combination with osthole in HER2-overexpressing cancers.…”

Autosomal eQTLs for liver-expressed genes. by Tisha Melia (603850)

“…The middle hinge of each boxplot indicates the median, and the lower and upper hinges indicate the first and third quartiles. Whiskers mark 1.5 * IQR value. Red arrows indicate a decrease in female liver expression in NZO/HiLtJ mice and an increase in male liver expression in CAST/EiJ mice, both of which abolish the sex-specific expression seen in the respective mice strain.…”

Investigation of the Adsorption Behavior of Organic Sulfur in Coal via Density Functional Theory (DFT) Calculation and Molecular Simulation by Yu Zhang (12946)

“…In this paper, we have investigated the chemical adsorption behavior of O₂ on five types of organic sulfur (thiol, sulfoxide, thioether, sulfone, and thiophene) in polycyclic aromatic hydrocarbon (PAH) sheets using density functional theory (DFT) calculations. …”

Image_2_Hepatitis C virus alters the morphology and function of peroxisomes.TIF by Esther Martin de Fourchambault (17017134)

“…HCV is known to disturb the metabolism of infected cells, especially lipid metabolism and redox balance, but the mechanisms leading to HCV-induced pathogenesis are still poorly understood. In an APEX2-based proximity biotinylation screen, we identified ACBD5, a peroxisome membrane protein, as located in the vicinity of HCV replication complexes. …”

Effects of PANDER overexpression on key enzymes of triglyceride hydrolysis in liver and adipose tissue of mice. by Xiaoqing Mo (2217691)

Image 2_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif by Yiping Cao (1229856)

“…Introduction<p>The paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A_2A receptor (A_2AR) in the PVT in regulating pain sensation and non-opioid analgesia.…”

Image_2_A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency.tiff by Huiping Li (617425)

“…With increased interferon-γ transcription in T and natural killer cells, meningeal macrophages showed decreased suppression and increased activity in Mecp2-deficienct mice. …”

Table_2_Systematic review on fiscal policy interventions in nutrition.DOCX by Jane Hammaker (14188877)

“…</p>Results<p>Our initial search returned 2,113 de-duplicated studies, and ultimately 24 impact evaluations and two systematic reviews met final eligibility criteria and represented unique evaluations. …”

Myotrauma is resolved faster in <i>Phd2</i>-hypomorphic mice. by Stephan Settelmeier (8849603)

“…Due to contusion artefacts, areas may appear separated. We observed no difference in acute trauma size between the genotypes indicating a standardized impact procedure. …”

Table_2_Systematic review on fiscal policy interventions in nutrition.DOCX by Jane Hammaker (14188877)

“…</p>Results<p>Our initial search returned 2,113 de-duplicated studies, and ultimately 24 impact evaluations and two systematic reviews met final eligibility criteria and represented unique evaluations. …”

Table_2_Captivity Influences the Gut Microbiome of Rhinopithecus roxellana.XLS by Xiaochen Wang (235611)

Image_2_Analysis of LINE1 Retrotransposons in Huntington’s Disease.JPEG by Lavinia Floreani (11946644)

“…The length of the expanded CAG tract is related to age at disease onset, with longer repeats leading to earlier onset. Here we carried out bioinformatic analysis of public RNA-seq data of a panel of HD mouse models showing that a decrease of L1 RNA expression recapitulates two hallmarks of the disease: it correlates to CAG repeat length and it occurs in the striatum, the site of neurodegeneration. …”

Table_2_Systematic review on fiscal policy interventions in nutrition.DOCX by Jane Hammaker (14188877)

“…</p>Results<p>Our initial search returned 2,113 de-duplicated studies, and ultimately 24 impact evaluations and two systematic reviews met final eligibility criteria and represented unique evaluations. …”

Anti-Fya Hemolytic Transfusion Reaction in a Recipient of a Fya-positive Kidney by Luis Manon (14416063)

Image2_Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells.TIF by Lei Hong (343013)

“…The aim of this study was to explore the effects of folic acid on cardiomyocytes cultured under high glucose and fat (HGF) conditions and type 2 diabetes mellitus (T2DM) mice, and elucidate the underlying mechanisms. …”