Image_1_Myeloid Ezh2 Deficiency Limits Atherosclerosis Development.eps by Annette E. Neele (6939713)

“…Because of its opposing function and importance of EZH2 in macrophage inflammatory responses, we here studied the role of myeloid EZH2 in atherosclerosis. …”

Treg-NASHcm and HFMCDm increased the inflammasome and inhibited the proliferative H9c2 cells. by Szu-Yu Liu (14241673)

Protein synthesis inhibition induces <i>mtl-1</i> expression in response to deregulated Ca²⁺ homeostasis. by Hans M. Dalton (5532668)

“…<p>(<i>A</i>-<i>B</i>) Organismal expression of <i>mtl-1</i> is increased while <i>mtl-2</i> is decreased in response to protein synthesis inhibition generated by RNAi in all cells (solid bars), hypodermal-specific RNAi (Hyp), or the germline-specific RNAi (Ger), but not the intestine-specific RNAi (Int) (<i>A</i>); this expression is more pronounced after 5 days (120hr) in the arrested state (<i>B</i>) (3 biological replicates). …”

Non-enzymatic pyroglutamate (pE) formation by acidic and elevated temperature conditions of Aβ(E3Q-40) (a), Aβ(E3Q-42) (b) and wild type Aβ(3–40) (c). by Christina Dammers (803567)

“…Peaks for non-modified peptides decreased while peaks for the pEAβ variants appeared at a longer retention time. …”

Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus by Adeline Kerviel (3332727)

“…To investigate the role of these two M1 basic domains in influenza A(H1N1)pdm09 virus molecular assembly, we analyzed M1 attachment to membranes, virus-like particle (VLP) production and virus infectivity. …”

The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat by Susanne Kurz (759116)

“…Notably, A2M is known to dramatically decrease with age in humans. …”

Table_2_Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokin... by Ying Shao (200846)

“…Mechanistically, the ER stress and ROS, together with decreased mitochondrial OXPHOS complexes, facilitate a proinflammatory response and TI. …”

Rituximab: A Review in Pemphigus Vulgaris by James E. Frampton (4995257)

Distinct Roles of ComK1 and ComK2 in Gene Regulation in <em>Bacillus cereus</em> by Aleksandra M. Mirończuk (215134)

“…<em>comK1</em> and <em>comK2</em> overexpression and deletion studies using transcriptomics techniques showed that ComK1 enhances and ComK2 decreases expression of the <em>comG</em> operon, when <em>B. subtilis</em> ComK was overexpressed simultaneously.…”

Identification of a Novel Variant <i>c.163delG</i> in <i>HBB</i> Gene Resulting in a Beta Null Phenotype in a Proband with Thalassemia Intermedia by M. Mamata (17831752)

Reducing healthcare-associated infections incidence by a probiotic-based sanitation system: A multicentre, prospective, intervention study by Elisabetta Caselli (304287)

“…PCHS was associated with a significant decrease of HAI cumulative incidence from a global 4.8% (284 patients with HAI over 5,930 total patients) to 2.3% (128 patients with HAI over 5,531 total patients) (OR = 0.44, CI 95% 0.35–0.54) (P<0.0001). …”

Table1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Genetic... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

DataSheet1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Gen... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

Image1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Genetic... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2 by Wenyang Hou (4348459)

“…We show that <i>Tmed2</i>^<i>99J/+</i> mice had decreased levels of TMED2 and TMED10, dilated endoplasmic reticulum membrane, and increased phosphorylation of eIF2α, indicating ER-stress and activation of the UPR. …”

Categorization of the genes differentially expressed in the <i>Otx2</i> CKO retina. by Yoshihiro Omori (221477)

“…We used GO term data on 101 probes with decreased expression in the <i>Otx2</i> CKO at P1 (signal log ratio ≤−1.0, signal intensity ≥50), 36 probes with increased expression in the <i>Otx2</i> CKO at P1 (signal log ratio ≥+0.5, signal intensity ≥50), 241 probes with decreased expression in the <i>Otx2</i> CKO at P12 (signal log ratio ≤−2.5, signal intensity ≥100), and 121 probes with increased expression in the <i>Otx2</i> CKO at P12 (signal log ratio ≥+2.5, signal intensity ≥100).…”

Table2_MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development.DOCX by Hong Chen (108084)

“…We demonstrated that MAP3K1^R186G variant enhances binding to the RhoA and improves its own stability, resulting in the activation of the Wnt4/β-catenin/FOXL2 pathway. …”

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation by Relja Popovic (626043)

“…Despite the net decrease in H3K27 methylation, specific genomic loci exhibit enhanced recruitment of the EZH2 histone methyltransferase and become hypermethylated on this residue. …”

Table_2_Increased Expression of PPAR-γ Modulates Monocytes Into a M2-Like Phenotype in SLE Patients: An Implicative Protective Mechanism and Potential Therapeutic Strategy of Syste... by Yu Liu (6938)

“…Additionally, PPAR-γ expression decreased in the SLE patients with skin lesion. Furthermore, we demonstrated that Pam3CSK4 stimulation can decrease the expression of CCR7, CD80, IL-1β, IL-6, IL-12, and NF-κB which were related to the M1-like subset of monocytes and increased the expression of ARG1 which was related to the M2-like subset through upregulated PPAR-γ expression and consequently downregulated NF-κB expression in the CD14⁺ monocytes in a time-dependent manner. …”

The average performance of two-sample testing approaches with smaller non-faller population. by Ioannis Bargiotas (3390458)

“…Decreasing the non-faller population leads to lower chance of distinguishing the two groups. …”