DHA combined with the glycolysis inhibitor decreases cell viability and induces apoptosis in NSCLC cells. by Yan-jun Mi (264759)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Decreased cell growth of PGRN knock-out cell line as determined by the MTT assay. by Weifeng Zhang (134361)

Muscle quality, but not muscle thickness, is decreased in different age groups of active older women by Pedro Lopez (4530202)

Introduction of the D409V point mutation to the <i>GBA1</i> gene does not affect <i>GBA1</i> mRNA transcription or GCase protein translation. by Nicole K. Polinski (10947787)

Fig 5 - by Ke Lu (124270)

Subjects:

Nepmucin/CD300LG expression is decreased in tumors and tumor-draining lymph nodes. by Eiji Umemoto (1637)

Jurkat and HeLa survival decreases with increasing electric field amplitude and pulse number. by Bennett L. Ibey (357053)

“…For all exposures, Jurkat cells are more sensitive than HeLa cells. Data points represent the average survival. (mean +/−s.e., n = 3–5).…”

Lipolytic treatment decreased cellular neutral lipids and increased extracellular fatty acids and glycerol. by Caroline Louis (332423)

“…Cellular neutral lipids (corresponding to µmol of fatty acids in cellular neutral lipids) were expressed per mg of total cell protein (A). A significant decrease of cellular lipid contents was noted throughout the lipolytic process for the conditions with PCB-28 (<i>p</i> = 0.005) and the cocktail of PCBs (<i>p</i> = 0.029). …”

Decreased expression of MHCII in antigen presenting cells from the lungs of IL-19-/- mice. by Carol Hoffman (196241)

<i>SLC2A2</i> is essential for liver differentiation in developing vertebrates by Yejin Kim (740789)

“…Total RNA was isolated from uninjected control and <i>SLC2A2</i> MO‐injected embryos (2.5, 5, and 10 ng). …”

CsA reduces Flk1 protein expression and significantly decreases the percentages of Flk1+ cells. by Seung-Cheol Choi (686982)

Image_1_Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons.... by Yize Li (471459)

“…Artesunate normalized paclitaxel-related expression changes in DRG mGluR5, NR1, and GluA2, as well as six paclitaxel related neuroinflammation markers. …”

K⁺-leak channels enhance the growth of pectoral fin buds. by Xiaowen Jiang (8291814)

Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

“…</p><p>Methods</p><p>We used a mathematical model to compare three potential ART initiation criteria: 1) CD4 <350/μL (<i>ART<350/μL</i>); 2) CD4 <500/<i>μ</i>L (<i>ART<500/μL</i>); and 3) ART at presentation (<i>Immediate ART</i>). …”

PKCε activation induces aggrecan gene expression, decreases ADAMTS5, and detection of ADAMTS-5-depended cleavage of ECM aggrecan through upregulation of hsa-miR-377 expression. by Emmanouella Tsirimonaki (490707)

“…<p>(<b>A</b>) RT-PCR detected the relative expression of ACAN, MKI67, ADAMTS5 after treatment of NP cells with 1 μM ψεRACK (or vehicle) for indicated times and revealed that time-dependent activation of PKCε significantly increased the mRNA expression for aggrecan, while in an opposing manner decreased ADAMTS5; mRNA levels of the proliferation marker Ki67 became barely detectable after 8 hours of PKCε activation. …”

FLIM-FRET measurements with KIRIN1 sensor detects relative changes in intracellular K⁺. by Xiaowen Jiang (8291814)

“…For cell patch clamping and FLIM measurements, each data point represents 1 cell (A, B, C). For fish embryo FLIM imaging, we measured 2 or 3 locations in each tissue of 1 fin bud per embryo. …”

Foxm1 deletion after tumor initiation decreases lung tumor expansion/progression. by I-Ching Wang (348231)

I890T markedly decreases peak <i>I</i>_Na. by Anna Tarradas (105463)