The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in <em>dy</em> Mouse Model of Muscular Dystrophy by Yoram Nevo (226898)

“…FTS treatment significantly decreased RAS expression and activity. In addition, phosphorylation of ERK, a Ras downstream protein, was significantly decreased following FTS treatment in the <em>dy^2J</em>/<em>dy^2J</em> mice. …”

Table 2_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx by Jiahao Zhou (11385383)

“…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.</p>Methods<p>Targets of five high-frequency herbs (Hedysarum multijugum Maxim, Radix Bupleuri, Prunella vulgaris, Fritillaria thunbergii Bulbus, and Angelicae sinensis Radix) were obtained from the TCMSP and Swiss Target Prediction databases. …”

Datasheet5_Inhibition of angiogenesis and regenerative lung growth in Lepob/ob mice through adiponectin-VEGF/VEGFR2 signaling.pdf by Tendai Hunyenyiwa (11497900)

“…Post-PNX regenerative lung growth and increases in the levels of VEGF and VEGFR2 are inhibited in adiponectin knockout mice. Adiponectin stimulates angiogenic activities in human lung endothelial cells (ECs), which is inhibited by decreasing the levels of transcription factor Twist1. …”

Effect of compound 16 and m-AMSA on relaxation of supercoiled pBS-SK (+) DNA by human recombinant Topo II. by Ahmed A. Gaber (13302308)

Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts by Kristine Yttersian Sletta (4386352)

“…Treatment effects were determined by assessment of tumor growth, proliferation (Ki67-staining), angiogenesis (CD31-staining), metastasis (immunostaining), EMT markers (western blot), stromal components collagen type I, Itgb1 and FSP1 (immunostaining) and chemotherapeutic efficacy (5FU).</p><p>Results</p><p>HBOT significantly suppressed tumor growth in both the triple positive and negative tumors, and both MDA-MB-231 and BT-474 showed a decrease in proliferation after HBOT. …”

Image_2_Humoral Response Following Triple Dose of mRNA Vaccines Against SARS-CoV-2 in Hemodialysis Patients: Results After 1 Year of Follow-Up.JPEG by Eduardo Gallego-Valcarce (13030110)

“…Multivariate logistic regression analyses were used to identify features associated with a sustained humoral immune response.</p>Results<p>After the initial two SARS-CoV-2 mRNA vaccine doses, 77.8% of patients showed an immediate effective humoral response, decreasing to 52.5% after 4 months. …”

Rates of False-Negative Screening in Prostate Specific Antigen Secondary to 5-Alpha Reductase Inhibitor Usage: A Quality-Improvement Initiative by Justin Loloi (13160149)

“…However, 5-ARIs can decrease prostate specific antigen (PSA) by approximately half and therefore may lead to false negative PSA tests. …”

Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian models by Su-Jin Park (124392)

“…Of note, substitution of the PB2 gene segment of the H5N8 virus by that from the H5N1 virus resulted in a 1000-fold increase in virulence for mice compared with the parental virus (MLD₅₀ decreased from 10^5.8 to 10^2.5 EID₅₀). …”

Table_5_PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells.DOCX by David K. Dansu (12252515)

“…This analysis identified a similar number of peptides in the two subcellular fractions and a total number of 57 proteins with statistically decreased symmetric methylation of arginine residues in the CRISPR-PRMT5 knockdown compared to control. …”

Image_2_Generation of a pdmH1N1 2018 Influenza A Reporter Virus Carrying a mCherry Fluorescent Protein in the PA Segment.tif by Ling Bu (11975516)

“…Through serial passage in mice, we generated a recombinant pdmH1N1 2009 IAV, A/Guangdong/GLW/2018 (GLW/18-MA), which encodes an mCherry gene fused to the C-terminal of a polymerase acidic (PA) segment and demonstrated comparable growth kinetics to the wild-type. …”

The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells by Courtney R. Schott (5904980)

Data Sheet 5_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf by Sadia Hamera (22524803)

“…Mutation and co-expression analysis support the formation of StACS3-StPP2C2 complexes, and silencing StPP2C2 increases StACS3 accumulation and alters its subcellular localization, demonstrating an antagonistic interplay between degradation and stabilization pathways. …”

Effect of the 5′ terminal stem–loop structure on the affinity of the 5′-UTR for Hfq and ribosomes by Taras Afonyushkin (8816)

“…All rights reserved</p> () 5′ end-labelled and RNAs were incubated alone (lanes 1 and 6) or with increasing amounts (2-, 4-, 6- and 8-fold molar excess) of Hfq-hexamer (lanes 2–5 and 7–10, respectively), and the resulting mixtures were then analysed on a 6% native gel. …”

Data_Sheet_1_T-Cell Subsets and Interleukin-10 Levels Are Predictors of Severity and Mortality in COVID-19: A Systematic Review and Meta-Analysis.pdf by Amal F. Alshammary (12471663)

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes by Fu-Hui Xiao (707993)

“…This pattern remains rather stable after including methylomes of two white individuals. Further analyses suggest that the observed DMRs likely have functional roles in regulating disease-associated gene expressions, with some genes [e.g. caspase 3 (<i>CASP3</i>)] being down-regulated whereas the others [i.e. interleukin 1 receptor, type 2 (<i>IL1R2</i>)] up-regulated. …”

Loss of Pgr in kisspeptin neurons leads to altered cyclicity, progressively impaired fertility, decreased serum LH, and absence of corpora lutea formation. by Arnon Gal (3150036)

The human neutrophil IL-1β secretory response, in contrast to the CXCL8/IL-8 secretory response decreases as MOI increases. by Florencia Sabbione (4862455)

Table_2_The Bacteriophage vB_CbrM_HP1 Protects Crucian Carp Against Citrobacter braakii Infection.DOCX by Chunzheng Huang (12509443)

“…In vitro, vB_CbrM_HP1 was capable of effectively killing bacteria (the colony count decreased by 4.7 log units at 5 h). …”

DataSheet_5_Variation in Plasma Levels of TRAF2 Protein During Development of Squamous Cell Carcinoma of the Oral Tongue.pdf by Xiaolian Gu (3497087)

“…TNF receptor associated factor 2 (TRAF2), decreased in pre-diagnostic plasma (< 5 years) but increased at diagnosis, was the only protein showing altered levels before and at diagnosis of SCCOT (p-value < 0.05). …”

Image_5_Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation.tif by Margaret K. Seeley-Fallen (12415624)

“…Notably, NMII inhibition by cIIAKO and inhibitors up-regulated BCR signaling in response to both surface-associated and soluble stimulation, increasing phosphorylated tyrosine, CD79a, BLNK, and Erk and decreasing phosphorylated SHIP1. …”