Image2_Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.TIF by Chao Hu (293389)

“…We found the levels of mGluR5 were significantly increased in a prion-infected cell line SMB-S15 and the cultured cells transiently express an abnormal form PrP (Cyto-PrP). …”

Image4_Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.TIF by Chao Hu (293389)

“…We found the levels of mGluR5 were significantly increased in a prion-infected cell line SMB-S15 and the cultured cells transiently express an abnormal form PrP (Cyto-PrP). …”

Image_2_The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer’s Disease.TIFF by Hyunjun Park (650105)

“…PSM-04 also decreased oxidative stress induced by H₂O₂ and apoptotic cell death induced by oligomeric Aβ. …”

DataSheet1_Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach.pdf by Philip Vlummens (221451)

“…The prognostic significance of the target genes was analyzed using publicly available gene expression data of MM patients (TT2/3 and HM cohorts). Hence, protein arginine methyltransferase 5 (PRMT5) was identified as a promising target. …”

Patch-clamp recording of SW480 and SW620 cells. by Yujie Sui (549090)

“…The currents were recorded at a holding potential of 0 mV followed by pulsing voltages between ±100 mV in steps of 20 mV. …”

Image_1_VdP5CDH is involved in melanin formation, stress resistance and play a regulatory role in virulence of Verticillium dahliae.TIF by Wanqing Sun (11476231)

“…In this study, VdP5CDH, the member of the ALDH_F4-17 family of carboxylate dehydrogenases, was identified in the genome of V. dahliae and investigated function in regulating virulence by generating gene deletion mutants and complementary mutants.…”

Table_1_VdP5CDH is involved in melanin formation, stress resistance and play a regulatory role in virulence of Verticillium dahliae.DOCX by Wanqing Sun (11476231)

“…In this study, VdP5CDH, the member of the ALDH_F4-17 family of carboxylate dehydrogenases, was identified in the genome of V. dahliae and investigated function in regulating virulence by generating gene deletion mutants and complementary mutants.…”

Image_2_VdP5CDH is involved in melanin formation, stress resistance and play a regulatory role in virulence of Verticillium dahliae.TIF by Wanqing Sun (11476231)

“…In this study, VdP5CDH, the member of the ALDH_F4-17 family of carboxylate dehydrogenases, was identified in the genome of V. dahliae and investigated function in regulating virulence by generating gene deletion mutants and complementary mutants.…”

<i>I</i>.<i>c</i>.<i>v</i> treatment with β-PAE improved 7-day survival in septic mice. by Ye Tian (220278)

Follow-up characteristics of ART-experienced people living with HIV-2 five years following virologic success in West Africa (N = 95). by Jean J. Koffi (20988337)

Factors Favoring Efficient Bifunctional Catalysis. Study of a Ruthenium(II) Hydrogenation Catalyst Containing an N-Heterocyclic Carbene with a Primary Amine Donor by Wylie W. N. O (1933417)

“…We conclude that complex <b>2</b> outperforms other ruthenium­(II) NHC complexes and some other phosphine–amine complexes for the H₂ hydrogenation of ketones due to the following factors: (1) the ease of formation of a highly reactive neutral hydride, (2) the presence of an NH₂ donor ligand required for bifunctional catalysis, and (3) the presence of an NHC donor to achieve the right balance of hydricity of the metal hydride and acidity of the protic amine group for the efficient H⁺/H^– transfer to the polar double bond.…”

Factors Favoring Efficient Bifunctional Catalysis. Study of a Ruthenium(II) Hydrogenation Catalyst Containing an N-Heterocyclic Carbene with a Primary Amine Donor by Wylie W. N. O (1933417)

“…We conclude that complex <b>2</b> outperforms other ruthenium­(II) NHC complexes and some other phosphine–amine complexes for the H₂ hydrogenation of ketones due to the following factors: (1) the ease of formation of a highly reactive neutral hydride, (2) the presence of an NH₂ donor ligand required for bifunctional catalysis, and (3) the presence of an NHC donor to achieve the right balance of hydricity of the metal hydride and acidity of the protic amine group for the efficient H⁺/H^– transfer to the polar double bond.…”

Factors Favoring Efficient Bifunctional Catalysis. Study of a Ruthenium(II) Hydrogenation Catalyst Containing an N-Heterocyclic Carbene with a Primary Amine Donor by Wylie W. N. O (1933417)

“…We conclude that complex <b>2</b> outperforms other ruthenium­(II) NHC complexes and some other phosphine–amine complexes for the H₂ hydrogenation of ketones due to the following factors: (1) the ease of formation of a highly reactive neutral hydride, (2) the presence of an NH₂ donor ligand required for bifunctional catalysis, and (3) the presence of an NHC donor to achieve the right balance of hydricity of the metal hydride and acidity of the protic amine group for the efficient H⁺/H^– transfer to the polar double bond.…”

Data Sheet 1_A dietary combination of red yeast rice, phytosterol ester and lycopene ameliorates hypercholesterolemia by regulating gut microbiota and activating hepatic FXR-LDLR/A... by Jingxian Xu (9374512)

“…Additionally, the RPL combination modulated bile acids profiles, leading to an increased proportion of hyodeoxycholic acid (HDCA) and a decreased level of omega-muricholic acid (ω-MCA). …”

(A) Model structure indicating pigs with maternal antibodies (M), susceptible (S), exposed (E), infected (I), recovered (R), and vaccinated (V) compartments. by Salah Uddin Khan (312105)

DataSheet1_Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokin... by Gang Li (34549)

“…<p>We aimed to develop a physiological-based pharmacokinetic and dipepidyl peptidase 4 (DPP-4) occupancy model (PBPK-DO) characterized by two simultaneous simulations to predict pharmacokinetic (PK) and pharmacodynamic changes of saxagliptin and metabolite M2 in humans when coadministered with CYP3A4 inhibitors or inducers. …”

a. The percentage of temporal wheat cultivation suitability showing the land distribution across five categories, very high, high, moderate, low and very low suitability, from 1970... by Khalifa M. Al-Kindi (3719854)

Image5_Phase behavior in multicomponent mixtures.jpeg by Luka Sturtewagen (17829197)

“…<p>In this article, we study the phase behavior of two polydisperse hydrocolloids: dextran and polyethylene oxide. …”

Student perceptions of open-note exams. by Emily P. Driessen (13267665)

“…<p>Students were asked a series of 5-point Likert scale questions. (A) Students report perceptions of increased exam performance, decreased anxiety, decreased personal study time investment, and decreased peer study time investment on open-note exams as compared to closed-note exams. …”

Coral physiology and microbiome dynamics under combined warming and ocean acidification by Andréa G. Grottoli (409324)

“…Two species of corals, <i>Acropora millepora</i> containing the thermally sensitive endosymbiont C21a and <i>Turbinaria reniformis</i> containing the thermally tolerant endosymbiont <i>Symbiodinium trenchi</i>, were exposed to control (26.5°C and <i>p</i>CO₂ of 364 μatm) and treatment (29.0°C and <i>p</i>CO₂ of 750 μatm) conditions for 24 days, after which we measured the microbial community composition. …”