Cre recombinase<i>-</i>mediated activation of the RIαB allele in ES cells decreases PKA activity and forskolin-stimulated CRE-luciferase reporter expression. by Brandon S. Willis (353418)

Data_Sheet_2_Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis.PDF by Byung Woo Kim (9658103)

“…Here, using CRISPR/Cas9 genome editing system and human induced pluripotent stem cells (iPSCs), we generated highly pure, iPSC-derived MNs with a SOD1-G93A missense mutation. With the wild-type cell line serving as an isogenic control and MNs from a patient-derived iPSC line with an SOD1-A4V mutation as a comparator, we identified pathological phenotypes relevant to ALS. …”

IGF-I decreases cell doubling time and induces the expression of Survivin at both mRNA and protein levels in the NRP-152 rat prostatic epithelial cell line. by Kyung Song (211116)

Table4_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Table3_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Image6_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.JPEG by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Table1_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Image1_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.JPEG by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Image4_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.JPEG by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Image3_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.JPEG by Long Yang (139573)

“…In the present study, the SEC5 expression level was found to be significantly decreased in primary dMϕs of patients with RSA, and downregulation of SEC5 expression inhibited M2 polarization and STAT6 phosphorylation, whereas SEC5 overexpression in the Mϕs promoted M2 polarization and STAT6 phosphorylation in vitro. …”

Zbtb7a is a widespread promoter- and enhancer-associated factor. by José Miguel Ramos Pittol (5309837)

“…(G) Enrichment of GO annotations among genes whose promoters are associated with Zbtb7a peaks (first column, “Zbtb7a promoter peak”) or with increased or decreased mRNA expression in control fibroblasts, compared to Zbtb7a-knockdown fibroblasts (second and third columns). …”

The <em>ABCA1</em> Gene R230C Variant Is Associated with Decreased Risk of Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease (GEA) Study by Teresa Villarreal-Molina (119637)

“…</p> <h3>Results</h3><p>The C230 allele was significantly associated with both lower HDL-C levels and a lower risk of premature CAD as compared to controls (OR = 0.566; <em>P_add</em> = 1.499×10⁻⁵). …”

Selectivity of PRMT5 inhibition with C220. by Shelby L. Sloan (10803222)

“…For all cell lines, effects of PRMT5 inhibition with C220 treatment on biomarkers of PRMT5 activity shows a dose-dependent decrease in global marks of symmetric di-methylarginine (SDMA) and symmetric di-methylation of histone H4 arginine-3 (H4R3me2s) with a minimal effect to PRMT5 or global asymmetric di-methylarginine (ADMA). …”

Table_1_Previous Use of Anti-Vascular Endothelial Growth Factor Receptor Agents Decreases Efficacy of Fruquintinib in Metastatic Colorectal Cancer Refractory to Standard Therapies.... by Lei Wang (6656)

“…Progression-free survival (PFS) and overall survival (OS) were assessed by a Kaplan-Meier analysis and log-rank test. A Cox regression model was performed to identify independent prognostic factors.…”

Propofol increased the number of the hippocampal pyramidal neurons and decreased the expression of the LC3-II protein and the number of lysosomes and autophagosomes in the ischemic... by Derong Cui (326839)

“…Statistical analyses were performed using a one-way ANOVA. **<i>p</i> < 0.01 vs. control group; ^##<i>p</i> < 0.01 vs. …”

Loss of <i>FGR41</i> attenuates virulence in a host immune system dependent manner. by Andrew S. Wagner (11331477)

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…The developed organohydrogel-based single-electrode triboelectric nanogenerator (OHS-TENG) shows low conductivity decrease (one order) and high output (1.02–1.81 W/m²), which is much better than reported OHS-TENGs (2–3 orders, 41.2–710 mW/m²). …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…The developed organohydrogel-based single-electrode triboelectric nanogenerator (OHS-TENG) shows low conductivity decrease (one order) and high output (1.02–1.81 W/m²), which is much better than reported OHS-TENGs (2–3 orders, 41.2–710 mW/m²). …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…The developed organohydrogel-based single-electrode triboelectric nanogenerator (OHS-TENG) shows low conductivity decrease (one order) and high output (1.02–1.81 W/m²), which is much better than reported OHS-TENGs (2–3 orders, 41.2–710 mW/m²). …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…The developed organohydrogel-based single-electrode triboelectric nanogenerator (OHS-TENG) shows low conductivity decrease (one order) and high output (1.02–1.81 W/m²), which is much better than reported OHS-TENGs (2–3 orders, 41.2–710 mW/m²). …”