Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome by Sriganesh Ramachandra Rao (5489456)

“…In the SLOS rat model, markedly increased RPE apical autofluorescence is observed, compared to untreated animals, which correlates with increased levels of A2E and other bisretinoids. Utilizing cultured human induced pluripotent stem cell (iPSC)- derived SLOS RPE cells, we found significantly elevated steady-state levels of 7-dehydrocholesterol (7DHC) and decreased cholesterol levels (key biochemical hallmarks of SLOS). …”

Changes in circulating endothelial progenitor cells predict responses of multiple myeloma patients to treatment with bortezomib and dexamethasone by L. Wang (2327974)

“…There were no significant differences among these groups at baseline day 1 (P>0.05). cEPC levels decreased slightly at day 21 (8.2±3.3 cEPCs/μL) vs day 1 (8.4±2.9 cEPCs/μL) in good responders (P>0.05). …”

Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia by Pernille Rudebeck Mogensen (8677164)

“…Hypertriglyceridemia was not associated with body mass index (P = 0.71). Five percent of patients had mild hypercholesterolemia, 14% had mild hypocholesterolemia, 13% had decreased and 1% elevated LDL-levels. …”

The–log p-value graphs for the LOO-W analysis for <i>BRCA2</i>, <i>BRCA1</i> and <i>SMG1</i>. by Cavin Wong (7330154)

“…<p>A decrease in the–log p-value is an increase in p-value signifying the window dropped contains variants driving the association with PC risk. …”

BDNF-secretion per cell after HBO treatment. by Jennifer Schulze (2502799)

“…After one HBO treatment the HBO-treated NIH3T3/BDNF fibroblasts released 0.62 pg BDNF per cell and the NOR-treated cells released 0.64 pg/cells. After five treatments, the BDNF secretion per cell decreased to 0.52 pg per cell for the normoxic control and to 0.20 pg per cell for the HBO-treated fibroblasts. …”

Zerovalent [Pd(NHC)(Alkene)_1,2] Complexes Bearing Expanded-Ring N‑Heterocyclic Carbene Ligands in Transfer Hydrogenation of Alkynes by Peter Hauwert (2003662)

“…Their strong σ-donor character is reflected in a decrease in IR stretching frequency for the CO bond of the maleic anhydride ligands (<b>8</b>–<b>14</b>) in comparison to their five-membered counterparts. …”

Reducing nitrogen inputs mitigate <i>Spartina</i> invasion in the Yangtze estuary by Xiao Xu (9506213)

“…</p><p dir="ltr">We then validated the growth dynamics (aboveground biomass, g/m2) of both species in the ambient plots of the SINE experiment after reducing N inputs.…”

Image_1_Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity.TIF by Toshihiro Tsuruda (90244)

“…The prevalence increased with pathological staging [9% (3 of 33) at early-stage (Stage 0–I); 63% (22 of 35) at advance-stage (Stage II–IV and recurrence)]. In addition, frequency of positive staining for TNNT2 increased with pleural (χ² = 5.877, P = 0.015) and vascular (χ² = 2.449, P = 0.118) invasions but decreased with lymphatic invasion (χ² = 3.288, P = 0.070) in specimens performed surgical resection. …”

Isolation of lizard populations measured with molecular genetic data – Podarcis guadarramae in the Ria de Arosa archipelago by Raluca I. Băncilă (3363557)

“…Under a documented paleogeographic history of the Ria de Arosa archipelago, northwestern Spain, predictions can be made on the duration and strength of isolation of <i>Podarcis guadarramae </i>lizard populations that were ‘captured’ on the islands when sea-levels rose. We predict that genetic diversity: i) is lower on islands than on the mainland, ii) increases with island size, and iii) decreases with increasing distance from the mainland. …”

Global and China trends in glomerulonephritis-induced chronic kidney disease: health inequities, risk factors and projections to 2050 by Mengting Wang (3757114)

“…Global slope index of inequality and concentration index decreased. In China, all ASRs decreased. Sex and age disparities were evident, with higher mortality observed among older populations. …”

Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer by Zhiyi Hu (6683516)

“…Further mechanistic studies showed that diosmetin inhibited the recruitment of RPA2 and RAD51, two critical factors involved in the HR repair pathway, upon the occurrence of DSBs. …”

Soil microbial properties and mineral protection drive carbon use efficiency along elevation gradient by Chengjie Ren (11717636)

“…<p dir="ltr">Understanding the elevational variation of soil microbial carbon use efficiency (CUE) can provide a better understanding for soil C-climate change feedback. Here, we used the 18O-H2O tracer method to quantify microbial CUE along an elevation gradient ranging from 840 m to 3400 m in the Eastern Himalaya. …”

Image4_Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways.jpeg by Ibrahim Musa (14519408)

“…Formononetin decreased beta-hexosaminidase release in RBL-2H3 cells and KU812 cells. …”

Image3_Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways.jpeg by Ibrahim Musa (14519408)

“…Formononetin decreased beta-hexosaminidase release in RBL-2H3 cells and KU812 cells. …”

Image1_Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways.jpeg by Ibrahim Musa (14519408)

“…Formononetin decreased beta-hexosaminidase release in RBL-2H3 cells and KU812 cells. …”

TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia by Xin-Jiang Lu (15884656)

“…TFPI levels are elevated in erythroblasts of human erythroblastic islands with JAK2V617F mutation and hypoxia condition. Erythroid lineage-specific knockout TFPI results in impaired erythropoiesis through decreasing ferrochelatase expression and heme biosynthesis in central macrophages. …”

Table1_Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.DOCX by Cara K. Campanaro (16712580)

“…</p><p>Results: First, the responses to sepsis varied across rats, but within rats the repeated measures of NLCI, CVC, as well as respiratory frequency (fR), HR, BP and HRV had a low coefficient of variation, (<0.2) at each time point. Second, HR, fR, and NLCI increased from BSLN on Days 1–3; whereas CVC decreased on Days 2 and 3. …”

<b>Complement inhibition reshapes tumor microenvironment and enhances clinical efficacy in immunotherapy</b> by Xi Jiao (10224854)

<i>Ralstonia pickettii</i> supplementation reduces glucose tolerance and augments inflammatory tone in DIO mice. by Shanthadevi D. Udayappan (4610638)

“…Gene expression was normalized using <i>36B4</i> as a housekeeping gene. N = 10 mice per group. Error bars are represented as mean ± SEM; p values were determined by Mann-Whitney U test or two-way ANOVA testing with Bonferroni post-test for multiple-comparison analysis (for OGTT). …”

Image_4_Bacteria Community Inhabiting Heterobasidion Fruiting Body and Associated Wood of Different Decay Classes.tif by Wenzi Ren (12491701)

“…Out of 7,462 operational taxonomic units (OTUs), about 5,918 OTUs were obtained from the fruiting body and 5,469 OTUs were obtained from the associated dead wood. …”