Table_1_Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.docx by Yun-Yi Zou (15774557)

“…Furthermore, we find that mitophagy was suppressed in NAFLD zebrafish liver with the decreased numbers of mitophagosomes, the inhibition of PTEN-induced kinase 1 (PINK1) – parkin RBR E3 ubiquitin protein ligase (PARKIN) pathway and upregulation of sequestosome 1 (P62) expression. …”

Data Sheet 1_Temporal trends and future projections of six major cancers among women of childbearing age in northeast Asia: analysis of data from the global burden of disease study... by Jingqian Liang (22701935)

“…ASMRs declined for all cancers, most sharply for uterine cancer (EAPC = –2.38%, 95% CI: –2.68 to –2.09). ASDRs declined across cancers, most prominently for CRC (EAPC = –2.30%, 95% CI: –2.49 to –2.12). …”

Table1_Protective role of remote ischemic conditioning in renal transplantation and partial nephrectomy: A systematic review and meta-analysis of randomized controlled trials.xlsx by Wenfu Zhang (2281144)

“…The 3-month estimated glomerular filtration rate (eGFR) was improved in the RIC group, which was statistically significant between the two groups on kidney transplantation [P < 0.001; mean difference (MD) = 2.74, confidence interval (CI): 1.41 to 4.06; I²= 14%], and the 1- and 2-day postoperative Scr levels in the RIC group decreased, which was statistically significant between the two groups on kidney transplantation (1-day postoperative: P < 0.001; MD = 0.10, CI: 0.05 to 0.15, I²= 0; 2-day postoperative: P = 0.006; MD = 0.41, CI: 0.12 to 0.70, I²= 0), but at other times, there was no significant difference between the two groups in Scr levels. …”

DataSheet1_Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach.docx by Wen-Di Wang (20400446)

“…Compared to the MI group, the Z-LIG/CGA group exhibited decreased ratios of the myocardial cell apoptosis-related proteins BAX/Bcl-2 and Cleaved Caspase-3/Caspase-3 in mice. …”

Image3_Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons.TIF by Markus T. Sainio (12084095)

“…Electrophysiological analysis revealed that motor neurons without NFL fired spontaneous and evoked action potentials with similar characteristics as controls. However, we found that, in the absence of NFL, human motor neurons 1) had reduced axonal caliber, 2) the amplitude of miniature excitatory postsynaptic currents (mEPSC) was decreased, 3) neurofilament heavy (NFH) levels were reduced and no compensatory increases in other filament subunits were observed, and 4) the movement of mitochondria and to a lesser extent lysosomes was increased. …”

Video1_A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping.MP4 by Kazunori Yoneda (11271150)

“…Based on our numerical analysis, we draw the following conclusions regarding the stretch activation mechanism: (i) the delayed force becomes larger than the original isometric force because the population of trapped myosin molecules and their average force increase after stretching; (ii) the delayed force has a duration of more than a few seconds owing to a fairly small rate constant of escape from the trapped state. …”

DataSheet1_A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping.PDF by Kazunori Yoneda (11271150)

“…Based on our numerical analysis, we draw the following conclusions regarding the stretch activation mechanism: (i) the delayed force becomes larger than the original isometric force because the population of trapped myosin molecules and their average force increase after stretching; (ii) the delayed force has a duration of more than a few seconds owing to a fairly small rate constant of escape from the trapped state. …”

DataSheet_1_The gastrointestinal antibiotic resistome in pediatric leukemia and lymphoma patients.docx by Tamara MacDonald (11789780)

“…</p>Results<p>We found that Bacteroidetes taxa and β-lactam resistance genes decreased, while opportunistic Firmicutes and Proteobacteria taxa, along with multidrug resistance genes, increased with repeated courses and/or duration of antibiotics. …”

Image4_Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons.TIF by Markus T. Sainio (12084095)

“…Electrophysiological analysis revealed that motor neurons without NFL fired spontaneous and evoked action potentials with similar characteristics as controls. However, we found that, in the absence of NFL, human motor neurons 1) had reduced axonal caliber, 2) the amplitude of miniature excitatory postsynaptic currents (mEPSC) was decreased, 3) neurofilament heavy (NFH) levels were reduced and no compensatory increases in other filament subunits were observed, and 4) the movement of mitochondria and to a lesser extent lysosomes was increased. …”

Cathepsin B-Deficient Mice Resolve <i>Leishmania major</i> Inflammation Faster in a T Cell-Dependent Manner by Orhan Rasid (552933)

“…We observed a more precocious development of T helper 1 responses accompanied by a faster decline of inflammation, resulting in resolution of footpad inflammation, reduced IFNγ levels and decreased parasite burden. …”

DataSheet1_Mathematical Modeling of a Supramolecular Assembly for Pyrophosphate Sensing.PDF by Fereshteh Emami (11860259)

“…The supramolecular example we chose for this investigation is a self-assembled sensor consists of a synthesized receptor, DPA (DPA = dipicolylamine)-appended phenylboronic acid (1) in combination with Zn²⁺(1.Zn) that forms various assemblies with a fluorophore like alizarin red S (ARS). …”

Video3_A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome.AVI by Mariam G. Aslanyan (6645584)

“…In contrast, in RPE1 cells we found that several structural components of caveolae (CAV1, CAVIN1, and EHD2) were highly enriched in our cilia affinity proteomics screen. …”

DataSheet_1_Identification of the major QTL QPm.cas-7D for adult plant resistance to wheat powdery mildew.docx by Hong Liu (50694)

“…P3228 exhibits stable adult-plant resistance to powdery mildew in the field over consecutive years. We identified two QTLs on chromosomes 7DS (QPm.cas-7D) and 1AL (QPm.cas-1A) contributed by P3228, and one QTL on 3DS (QPm.cas-3D) contributed by Gao 8901, which could explain 65.44%, 3.45%, and 2.18% of the phenotypic variances, respectively. …”

Image7_Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons.TIF by Markus T. Sainio (12084095)

“…Electrophysiological analysis revealed that motor neurons without NFL fired spontaneous and evoked action potentials with similar characteristics as controls. However, we found that, in the absence of NFL, human motor neurons 1) had reduced axonal caliber, 2) the amplitude of miniature excitatory postsynaptic currents (mEPSC) was decreased, 3) neurofilament heavy (NFH) levels were reduced and no compensatory increases in other filament subunits were observed, and 4) the movement of mitochondria and to a lesser extent lysosomes was increased. …”

Table1_A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome.XLSX by Mariam G. Aslanyan (6645584)

“…In contrast, in RPE1 cells we found that several structural components of caveolae (CAV1, CAVIN1, and EHD2) were highly enriched in our cilia affinity proteomics screen. …”

Image1_Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons.TIF by Markus T. Sainio (12084095)

“…Electrophysiological analysis revealed that motor neurons without NFL fired spontaneous and evoked action potentials with similar characteristics as controls. However, we found that, in the absence of NFL, human motor neurons 1) had reduced axonal caliber, 2) the amplitude of miniature excitatory postsynaptic currents (mEPSC) was decreased, 3) neurofilament heavy (NFH) levels were reduced and no compensatory increases in other filament subunits were observed, and 4) the movement of mitochondria and to a lesser extent lysosomes was increased. …”

Data_Sheet_1_The Microbiome Stress Project: Toward a Global Meta-Analysis of Environmental Stressors and Their Effects on Microbial Communities.docx by Jennifer D. Rocca (2403376)

“…Overall, we found that stressor exposure significantly decreases microbiome alpha diversity and increases beta diversity (community dispersion) across a range of environments and stressor types. …”

table3_eDNA Detection of Native and Invasive Crayfish Species Allows for Year-Round Monitoring and Large-Scale Screening of Lotic Systems.xlsx by Franziska Chucholl (10287689)

“…To ensure specificity each primer pair was tested in silico, in vitro, and in situ; 2) we assessed the influence of spatio-temporal variables (distance to upstream population, season, stream size) on eDNA detection in seven streams using two different detection methods (qualitative endpoint PCR and quantitative droplet digital PCR, ddPCR). …”

Video1_A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome.AVI by Mariam G. Aslanyan (6645584)

“…In contrast, in RPE1 cells we found that several structural components of caveolae (CAV1, CAVIN1, and EHD2) were highly enriched in our cilia affinity proteomics screen. …”

DataSheet_3_The gastrointestinal antibiotic resistome in pediatric leukemia and lymphoma patients.xlsx by Tamara MacDonald (11789780)

“…</p>Results<p>We found that Bacteroidetes taxa and β-lactam resistance genes decreased, while opportunistic Firmicutes and Proteobacteria taxa, along with multidrug resistance genes, increased with repeated courses and/or duration of antibiotics. …”