Image_3_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.JPEG by Katrina S. Hofstetter (17545425)

“…In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. We propose that morphogenesis of the ventral optic cup requires Cdc42 function for coordinated optic cup expansion and establishment of subretinal space, tissue tension, and differentiation of the ventral RPE layer.…”

DataSheet_1_Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells.docx by Huan Qu (1872379)

“…It exerts a pivotal role in modulating core genes involved in oxidative stress and inflammatory response processes in the ileum epithelial cells (IPI-2I). We observed that the DES extracted from red algae did not affect IPI-2I cell growth or survival. …”

Alteration of <em>POLDIP3</em> Splicing Associated with Loss of Function of TDP-43 in Tissues Affected with ALS by Atsushi Shiga (144249)

“…In the cells treated with TDP-43 siRNA, wild-type <em>POLDIP3</em> (variant-1) decreased and <em>POLDIP3</em> lacking exon 3 (variant-2) increased. …”

Video_11_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.AVI by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

Video_9_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.AVI by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

Video_6_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.AVI by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

The Systemic Inflammome of Severe Obesity before and after Bariatric Surgery by Ebymar Arismendi (631947)

“…</p><p>Methods</p><p>We studied 129 morbidly obese patients (96 females; age 46±12 years; body mass index [BMI], 46±6 kg/m²) before and one year after BS, and 20 healthy, never-smokers, (43±7 years), with normal BMI and spirometry.…”

DataSheet1_3,4-Methylenedioxy-β-Nitrostyrene Alleviates Dextran Sulfate Sodium–Induced Mouse Colitis by Inhibiting the NLRP3 Inflammasome.PDF by Juanjuan Zheng (1281486)

“…Here, we showed that MNS was more efficient in inhibiting the secretion of interleukin-1β (IL-1β) by blocking oligomerization of apoptosis-associated speck-like protein (ASC) than NLRP3-IN-2 and JC124. …”

Video_8_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.AVI by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

Table_1_Uncertainty in coprophilous fungal spore concentration estimates.DOCX by Angelina G. Perrotti (14292716)

“…Finally, the probability of encountering a CFS spore from a specific taxon occurring in moderate concentrations (1,000 spores/unit²) dramatically decreases after a low tracer count (∼50). …”

Image_1_N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors.TIF by Kristyna Skrenkova (5332883)

“…Finally, we found that the surface mobility of GluN3A-containing NMDARs in hippocampal neurons is increased following incubation with 1-deoxymannojirimycin (DMM, an inhibitor of the formation of the hybrid/complex forms of N-glycans) and decreased in the presence of specific lectins. …”

Table_1_Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population.XLSX by Bo-Hyun Kim (1766896)

“…The three most significant SNPs (rs4787307, rs9903904, and rs11079797) on these genes are associated with the regulation of the LCMT1, OSBPL7, and SCRN2 genes, respectively. These SNPs are involved in decreasing hippocampal volume and cognitive scores by mediating Aβ uptake. …”

Data_Sheet_1_Recycling Nutrient Solution Can Reduce Growth Due to Nutrient Deficiencies in Hydroponic Production.PDF by Alexander Miller (3433154)

“…Using image analysis of groups of plants, we identified that the negative effects of recycling on canopy area started 2 weeks after transplanting. …”

DataSheet1_High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker.PDF by Xingxing Dong (6495335)

“…We also demonstrated that TP53 mutation, DNA hypo-methylation, and the expression changes of three potential upstream transcription factors (EZH2, EGR1, and JUN) of CEMIP were likely to cause the hyperexpression of CEMIP in BC. …”

Video_7_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.AVI by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

DataSheet_1_Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells.zip by Huan Qu (1872379)

“…It exerts a pivotal role in modulating core genes involved in oxidative stress and inflammatory response processes in the ileum epithelial cells (IPI-2I). We observed that the DES extracted from red algae did not affect IPI-2I cell growth or survival. …”

Effects of Genetic Variants in <em>ADCY5</em>, <em>GIPR</em>, <em>GCKR</em> and <em>VPS13C</em> on Early Impairment of Glucose and Insulin Metabolism in Children by Jan Windholz (213607)

“…</p> <h3>Results</h3><p>The major allele (C) of rs2877716 (<em>ADCY5</em>) was nominally associated with decreased fasting plasma insulin (P = 0.008), peak insulin (P = 0.009) and increased QUICKI (P = 0.016) and Matsuda insulin sensitivity index (P = 0.013). rs17271305 (<em>VPS13C</em>) was nominally associated with 2 h blood glucose (P = 0.009), but not with any of the insulin or insulin sensitivity parameters. …”

Table_1_Uncertainty in coprophilous fungal spore concentration estimates.DOCX by Angelina G. Perrotti (14292716)

“…Finally, the probability of encountering a CFS spore from a specific taxon occurring in moderate concentrations (1,000 spores/unit²) dramatically decreases after a low tracer count (∼50). …”

Video_3_Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions.MP4 by Pablo Godoy (3425276)

“…We identified a number of GRACE strains that showed normal morphological development but exhibited different recognition and engulfment kinetics by cultured macrophages and characterized two mutants that modified interactions with the murine and human-derived macrophages. …”

A mathematical model for active contraction in healthy and failing myocytes and left ventricles by Li Cai (3899)

“…The predictions of the healthy LV model agreed well with the clinical measurements and other studies, and likewise, the results in the failing states were also consistent with clinical observations. In particular, we found that a low level of intracellular Ca²⁺ transient in myocytes can result in LV pump function failure even with increased myocardial contractility, decreased systolic blood pressure, and increased diastolic filling pressure, even though they will increase LV stroke volume. …”