Image1_Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma.jpeg by Danni Wang (3953762)

“…In the orthotopic transplanted tongue carcinoma in mice model, we confirmed that HF administration inhibited tumor growth and lymph node metastasis (LNM) with reduced CAF population, MMP2 expression and collagen deposition in tumor. …”

Image_1_Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma.... by Hao Chen (5190)

“…Mechanistically, EAEO significantly decreased the ratio of Bcl-2/Bax and resulted in the activation of caspase-9 and -3. …”

Discovery of Novel Pyrazolo[3,4‑<i>b</i>] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hyper... by Liqing Hu (9409143)

“…Given the unique advantages of significant vascular remodeling inhibition and moderate vascular relaxation based on the dual pathway regulation, we proposed <b>2</b> as a promising lead for anti-PAH drug discovery.…”

Data Sheet 1_Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways.zip by Karina M. Berschneider (14001561)

“…This could be traced back to reduced IL-2 responsiveness due to decreased CD25 (IL–2Rα chain) expression, accompanied by reduced IL-2 production. …”

Motor task-based differences in brain networks: Preliminary results by Da-hye Kim (796770)

“…For SW, the Active task also decreased in the high beta band in contrast with the MI task. …”

Data_Sheet_1_Unravelling Trait–Environment Relationships at Local and Regional Scales in Temperate Forests.docx by Rihan Da (12677207)

“…Multiple linear regression model was then used to explore the community-level trait–environment relationships. We found that (i) intraspecific trait variation contributed considerably to total trait variation and decreased with the spatial scale from local to regional; (ii) functional composition was mainly affected by soil and topography factors at the local scale and climate factor at the regional scale, while explaining that variance of environment factors were decreased with increasing spatial scale; and (iii) the main environment driver of functional composition was varied depending on the traits and spatial scale. …”

Mixture models. by Nedialko I. Krouchev (535037)

“…<p><b>A:</b> Red trace: Existence/creation <i>P</i> parameter-range for the 2 additional fixed points (saddle-node in the middle branch, and unstable center/focus in the top branch of the B.D.’s) With Δ<i>V</i>_1/2 = 13 mV, <i>P</i> ≥ 0.648, which is very close to the minimum relative <i>Na</i>/<i>K</i> conductivity ratio (0.663) needed for 3 FP’s in the single-<i>Na</i>_<i>v</i>-subtype model with Δ<i>V</i>_1/2 = 0 mV. …”

Radiation-induced neuroinflammation monitoring by the level of peripheral blood monocytes with high expression of translocator protein by Alla V. Rodina (14671622)

“…</p> <p>Hippocampal cytokines mRNA expression and the content of cells with high TSPO expression in the brain and peripheral blood monocytes were analyzed up to eight months after mice head γ-irradiation at a dose of 2 Gy or 8Gy.</p> <p>Mice irradiation at a dose of 8 Gy causes neuroinflammation, accompanied by an increase of M1 microglia and TSPO^high cells in the brain, elevated gene expression of pro-inflammatory and decreased of anti-inflammatory cytokines along with an increased number of microglia and astrocytes in the hippocampus. …”

Table_1_Bladder Cancer Exhibiting High Immune Infiltration Shows the Lowest Response Rate to Immune Checkpoint Inhibitors.XLSX by Shen Pan (4062178)

“…</p><p>Interpretation: Patients with high ICILs may benefit the least from treatment with IMCIs. Five key genes could predict ICILs in BLCA, and their high expression suggested that the response rate to IMCIs may decrease.…”

Table_3_Bladder Cancer Exhibiting High Immune Infiltration Shows the Lowest Response Rate to Immune Checkpoint Inhibitors.XLSX by Shen Pan (4062178)

“…</p><p>Interpretation: Patients with high ICILs may benefit the least from treatment with IMCIs. Five key genes could predict ICILs in BLCA, and their high expression suggested that the response rate to IMCIs may decrease.…”

Image_1_Bladder Cancer Exhibiting High Immune Infiltration Shows the Lowest Response Rate to Immune Checkpoint Inhibitors.JPEG by Shen Pan (4062178)

“…</p><p>Interpretation: Patients with high ICILs may benefit the least from treatment with IMCIs. Five key genes could predict ICILs in BLCA, and their high expression suggested that the response rate to IMCIs may decrease.…”

Early attachment of <i>B. pertussis</i> strains to abiotic surfaces. by Diego O. Serra (190806)

“…The number of WT bacteria in the inoculum was reduced from 1×10⁹ to 4×10⁸ CFUs ml⁻¹ so as to decrease the population of cells initially adhered to the level displayed by the Δ<i>fhaB</i> strain with a high inoculum (1×10⁹ CFUs ml⁻¹), and then incubated under normal biofilm culture conditions. …”

Speech compression in dysarthria (Utianski et al., 2019) by Rene L. Utianski (5721504)

“…The transcoding of the speech compression algorithm resulted in an enlarged vowel space area and associated improvements in vowel identification for 1 speaker and a smaller vowel space area and decreased vowel identification for the other speaker. …”

Supplementary Material for: Analysis of Geographic and Environmental Factors and Their Association with Cutaneous Melanoma Incidence in Canada by Berman-Rosa M. (12842984)

Data set for: Dominance is associated with reduced cleaning activity in group-living Elacatinus prochilos gobies by Renata Mazzei (9970475)

“…We found that dominance significantly decreased cleaning activity in sponge-dwellers but not in cleaners. …”

Presentation 1_Fruit-specific overexpression of lipoyl synthase increases both bound and unbound lipoic acid and alters the metabolome of tomato fruits.pptx by María Paz Covarrubias (9959594)

“…</p>Discussion<p>In addition, as the overexpression of SlLIP1 results in lower transcript levels of E2 PDH and E2 kGDH, and enhanced amounts of LA-bound targets, we speculate that the proportion of unlipoylated E2 subunits of PDH and kGDH may have decreased. …”

DataSheet_1_S100A9 Activates the Immunosuppressive Switch Through the PI3K/Akt Pathway to Maintain the Immune Suppression Function of Testicular Macrophages.docx by Zun Pan Fan (11605789)

“…Treatment with S100A9 and PI3K inhibitor decreased the proportion of M2-type TMs in control and UPEC-infected mouse. …”

Forest plot. by Jiaxuan Wen (12531339)

“…The association between dexmedetomidine and bradycardia was also found to be significant (RR 2.21, 95%CI 1.31, 3.73, p = 0.003). We found no difference in hypotension (RR = 1.44, 95%CI = 0.87, 2.38, P = 0.16), mortality (RR = 1.02, 95%CI = 0.83, 1.25, P = 0.87), neither in terms of adverse effects requiring intervention, hospital length of stay, or sedation effects.…”

<i>In Vitro</i> Ischemia Triggers a Transcriptional Response to Down-Regulate Synaptic Proteins in Hippocampal Neurons by Joana Fernandes (587970)

“…Additionally, OGD decreased the mRNA and protein expression levels of the GluA1 AMPA receptor subunit as well as the GluN2A and GluN2B subunits of NMDA receptors, but increased the mRNA expression of the GluN3A subunit, thus altering the composition of ionotropic glutamate receptors in hippocampal neurons. …”

Trial sequential analysis. by Jiaxuan Wen (12531339)

“…The association between dexmedetomidine and bradycardia was also found to be significant (RR 2.21, 95%CI 1.31, 3.73, p = 0.003). We found no difference in hypotension (RR = 1.44, 95%CI = 0.87, 2.38, P = 0.16), mortality (RR = 1.02, 95%CI = 0.83, 1.25, P = 0.87), neither in terms of adverse effects requiring intervention, hospital length of stay, or sedation effects.…”