Multicenter Phase 2 Trial of Sirolimus for Tuberous Sclerosis: Kidney Angiomyolipomas and Other Tumors Regress and VEGF- D Levels Decrease by Sandra L. Dabora (206838)

“…<div><h3>Background</h3><p>Tuberous sclerosis (TSC) related tumors are characterized by constitutively activated mTOR signaling due to mutations in <em>TSC1</em> or <em>TSC2</em>.</p> <h3>Methods</h3><p>We completed a phase 2 multicenter trial to evaluate the efficacy and tolerability of the mTOR inhibitor, sirolimus, for the treatment of kidney angiomyolipomas.…”

MCP-1-deficiency decreased CD11c-expressing cells via impairing the production of ROS and decreased activation of PLCγ2, Akt, and ERK upon M-CSF stimulation in BMM. by Woon-Ki Kim (447798)

“…<p>BMMs from WT (open bar) and MCP-1-KO mice (oblique-lined bar) were incubated in the presence of M-CSF (30 ng/ml) with U73122 (10 µM), Akt inhibitor IV (0.3 µM), PD098059 (5 µM), DPI (50 nM), NAC (3 mM), or H₂O₂ (300 µM) for 4 d (A). *, <i>P</i><0.05; ***, <i>P</i><0.001 compared with vehicle-treated WT cells. …”

Mutant channel with deletion of the S10 region has decreased surface expression in a stable HEK293 cell line. by Shumin Bian (191969)

“…Surface to total ratios were obtained by integration of the histograms. There is a 40% decrease in surface protein expression for the HSloΔS10 mutant determined by the surface to total HSlo ratio (+/− SEM, p = 0.032 in two sample t-test .n = 5).…”

Effect of <i>slc43a3</i> deletion on physical activity of male and female WT and KO mice. by Aaron L. Sayler (19797446)

DataSheet_2_Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages.pdf by Cassandra L. R. van Doorn (11388245)

The Transition from a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk by Heba M Ismail (9568748)

“…Conclusions</p> <p>A transition from an increase to a decrease in AUC C-peptide approximately 1.5 years pre-diagnosis was validated in two independent cohorts. …”

While regenerative currents increase the cell sensitivity to low frequency fields, restorative currents decrease it and induce a resonance. by Florian Aspart (3366014)

Increased reactive oxygen species (ROS) production and decreased mitochondrial membrane potential in <i>Tet-mev-1</i> hepatocytes. by Tadashi Moro (844328)

Exposure to LPS decreases insulin, PDX-1 and MafA gene expression in isolated islets via TLR4. by Julie Amyot (167960)

The deletion of <i>gdpP</i> in <i>S. pyogenes</i> decreases the sensitivity to a β-lactam antibiotic, ampicillin. by Kyu Hong Cho (322773)

S1 Data - by Jordan A. Gunning (18143970)

“…Specifically, total immune cells (CD45+) decrease at days 2 and 5 following IR, macrophages (F4/80+CD11b+) decrease at day 2 and 5 and increase at day 30, while neutrophils (Ly6G+CD11b+) significantly increase at day 30 following IR. …”

Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer by Li Xu (108702)

“…We screened for CHD 9 expression using immunohistochemical analysis in 87 surgical CRC specimens and found that the expression was upregulated in 81.5% of the cases, while 7.4% were decreased; in the remaining 11.1% of the cases, levels were not altered. …”

<i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus. by David F. Wozniak (78177)

“…(C) <i>Nf1</i> OPG mice also showed a trend toward decreased general ambulatory activity although this difference was also not significant (p = 0.053). …”

Image_3_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.tif by Nobuhiko Ebisutani (9764468)

“…A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. …”

Image_1_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.TIF by Nobuhiko Ebisutani (9764468)

“…A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. …”

<i>Bahd1</i>-knockout mice display decreased weight and fat mass and lower cholesterol, glucose and leptin levels. by Goran Lakisic (2551717)

Video_2_Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.MP4 by Julia Swan (14556800)

Video_2_Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.MP4 by Julia Swan (14556800)

S2 Data - by Dwight D. Harris (14484648)

“…Immunoblot showed a reduction in Jak2, the pSTAT3 to STAT 3 Ratio, pSMAD 2/3, and SMAD 2/3, and an increase in STAT 3 in the SIT group relative to CON (all p<0.05). …”

<b>Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells</b> by Saddam Hussain (22282372)

“…Using a DNA fiber assay we observed decreased replication fork progression, which coincided with increased micronuclei formation. …”