Implementation of a rapid response team in a large nonprofit Brazilian hospital: improving the quality of emergency care through Plan-Do-Study-Act by Meire Cavalieri Almeida (6826961)

“…Results: Between 2013 and 2014, the rapid response team attended to 2,296 patients. This study showed a nonsignificant reduction in mortality from 8.3% in cycle 1 to 5.0% in cycle 4; however, death rates remained stable in cycles 3 and 4, with frequencies of 5.2% and 5.0%, respectively. …”

Implementation of a rapid response team in a large nonprofit Brazilian hospital: improving the quality of emergency care through Plan-Do-Study-Act by Meire Cavalieri Almeida (6826961)

“…Results: Between 2013 and 2014, the rapid response team attended to 2,296 patients. This study showed a nonsignificant reduction in mortality from 8.3% in cycle 1 to 5.0% in cycle 4; however, death rates remained stable in cycles 3 and 4, with frequencies of 5.2% and 5.0%, respectively. …”

The expected effect of hydrocortisone on sepsis pathophysiology in patients in sub-Saharan Africa. by Phoebe Gruccio (21029968)

List of antibodies used in this study. by Riya Ghosh (17116962)

“…<div><p>We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)^D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. …”

List of primers used in this study. by Riya Ghosh (17116962)

“…<div><p>We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)^D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. …”

Striking image. by Riya Ghosh (17116962)

“…<div><p>We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)^D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. …”

Study subjects. by Riya Ghosh (17116962)

“…<div><p>We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)^D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. …”

List of reagents used in this study. by Riya Ghosh (17116962)

“…<div><p>We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)^D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. …”

Image_2_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…From the specimen analysis of the IDD patients, we found phosphorylated eIF2α (p-eIF2α), ATF4 and Ihh protein levels were positively related while the NP tissue went degenerative. …”

Supplementary Material for: Cystamine Treatment Fails to Prevent the Development of Pulmonary Hypertension in Chronic Hypoxic Rats by Markvardsen L.K. (10714539)

“…<b><i>Introduction:</i></b> Pulmonary hypertension is characterized by vasoconstriction and remodeling of pulmonary arteries, leading to right ventricular hypertrophy and failure. We have previously found upregulation of transglutaminase 2 (TG2) in the right ventricle of chronic hypoxic rats. …”

Loss of the Synaptic Vesicle Protein SV2B Results in Reduced Neurotransmission and Altered Synaptic Vesicle Protein Expression in the Retina by Catherine W. Morgans (267419)

“…Of the three isoforms expressed in mammals, SV2B is the most divergent. Here we report studies of SV2B location and function in the retina. …”

DataSheet_1_A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinom... by Rone A. De Grandis (11017173)

“…Interestingly, we found that N-acetyl-L-cysteine, a ROS scavenger, suppressed the generation of intracellular ROS induced by complex (2), and decreased its cytotoxicity, indicating that ROS-mediated DNA damage leads the DU-145 cells into apoptosis. …”

Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced <i>Salmonella</i> Typhimurium invasion by Lingyan Jiang (4063771)

“…Typhimurium is not clear. Here, we report a signal transduction pathway that activates SPI-1 expression in response to low O₂. …”

Data Sheet 2_TSG-6 promotes healing of critical-sized bone defects in mice.pdf by Oliver Küppers (22742732)

“…To investigate the in vivo relevance, we assessed the effects of locally delivered recombinant TSG-6 (rTSG-6), embedded in a collagen gel, on bone regeneration in a 1.5 mm critical-sized femoral defect model in male C57BL/6J mice. …”

Inhibition of Cav3 binding affects Ca²⁺ homeostasis, cytoskeletal-membrane interactions and MSC activity. by Haixia Huang (452278)

“…(B) We loaded myotubes with Fluo4-AM and monitored Ca²⁺ levels during application of test substances. …”

image1_Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats.tif by Fanyuan Zhou (10431314)

“…However, the underlying mechanism has not been well elucidated. In the present study, we measured the markers of apoptosis, inflammation, oxidative stress, and nuclear factor erythroid 2–related factor 2 (Nrf2) signaling to investigate the effects of JPYS formula on renal function and fibrosis and its molecular mechanism in an established animal model of 5/6 nephrectomized (5/6Nx) rats. …”

table1_Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats.docx by Fanyuan Zhou (10431314)

“…However, the underlying mechanism has not been well elucidated. In the present study, we measured the markers of apoptosis, inflammation, oxidative stress, and nuclear factor erythroid 2–related factor 2 (Nrf2) signaling to investigate the effects of JPYS formula on renal function and fibrosis and its molecular mechanism in an established animal model of 5/6 nephrectomized (5/6Nx) rats. …”

A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models by Hao Zhang (15339)

“…However, the mTOR kinase exists in two distinct multiprotein complexes, mTORC1 and mTORC2, and both complexes may be critical regulators of cell metabolism, growth and proliferation. …”

Antimicrobial nano-zinc oxide-2S albumin protein formulation significantly inhibits growth of “<i>Candidatus</i> Liberibacter asiaticus” in planta by Dilip Kumar Ghosh (5843651)

“…The dynamics of <i>C</i>Las pathogen load of treated Mosambi plants was assessed using TaqMan-qPCR assay every 30 days after treatment (DAT) and monitored till 120 days. We observed that 2S albumin-Nano-ZnO formulation performed the best among all the treatments decreasing <i>C</i>Las population by 96.2%, 97.6%, 95.6%, and 97% of the initial bacterial load (per 12.5 ng of genomic DNA) at 30, 60, 90, and 120 DAT, respectively. …”

Data Sheet 2_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.pdf by Miguel Ângelo-Dias (20936444)

“…</p>Methods<p>A total of 50 pregnant and 30 age-matched non-pregnant women were recruited in a prospective cohort study. …”