Image_6_PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.JPEG by Lin Tuo (6089267)

“…Gluconeogenesis mainly occurs in the liver during fasting, and previous studies have demonstrated that PCK1 acts as a tumor suppressor in hepatocellular carcinoma (HCC); however, the role of PCK1 in cancer progression remains incompletely understood. In the current study, we found that PCK1 expression was decreased in HCC as compared to adjacent normal liver tissues, and low PCK1 expression correlated with poor patient prognosis. …”

Image_1.pdf by Stuart J. Grice (225342)

“…In this Drosophila model for CMT2D, we have previously shown that mutant gars expression decreases viability and larval motor function, and causes a concurrent build-up of mutant GlyRS at the larval neuromuscular presynapse. …”

Image_5_PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.JPEG by Lin Tuo (6089267)

“…Gluconeogenesis mainly occurs in the liver during fasting, and previous studies have demonstrated that PCK1 acts as a tumor suppressor in hepatocellular carcinoma (HCC); however, the role of PCK1 in cancer progression remains incompletely understood. In the current study, we found that PCK1 expression was decreased in HCC as compared to adjacent normal liver tissues, and low PCK1 expression correlated with poor patient prognosis. …”

Table_1_PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.XLSX by Lin Tuo (6089267)

“…Gluconeogenesis mainly occurs in the liver during fasting, and previous studies have demonstrated that PCK1 acts as a tumor suppressor in hepatocellular carcinoma (HCC); however, the role of PCK1 in cancer progression remains incompletely understood. In the current study, we found that PCK1 expression was decreased in HCC as compared to adjacent normal liver tissues, and low PCK1 expression correlated with poor patient prognosis. …”

Image_4_PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.JPEG by Lin Tuo (6089267)

“…Gluconeogenesis mainly occurs in the liver during fasting, and previous studies have demonstrated that PCK1 acts as a tumor suppressor in hepatocellular carcinoma (HCC); however, the role of PCK1 in cancer progression remains incompletely understood. In the current study, we found that PCK1 expression was decreased in HCC as compared to adjacent normal liver tissues, and low PCK1 expression correlated with poor patient prognosis. …”

Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Yumi Shirai (759726)

“…Keap1 is a cytoplasmic protein that is essential for the regulation of Nrf2 activity. Here, we found that pretreatment with SFN attenuated cognitive deficits, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus after repeated administration of phencyclidine (PCP). …”

Data_Sheet_2_Jaguar Persecution Without “Cowflict”: Insights From Protected Territories in the Bolivian Amazon.PDF by Jillian Knox (8152257)

“…Using in-person structured interviews, we investigated attitudes and norms related to jaguars and jaguar killing, self-reported past killing of jaguars, and demographic variables in two protected areas and an indigenous territory: Integrated Management Area (IMA) of Santa Rosa del Abuná (Santa Rosa, n = 224), Indigenous Territory Tacana II (n = 137), and Manuripi National Amazon Wildlife Reserve (MNAWR, n = 169). …”

Data_Sheet_2_Generation and Validation of miR-100 Hepatocyte-Specific Knock-Out Mice.PDF by Dong Yang (141041)

“…To understand miR-100 function in HCC genesis and development in vivo, we developed hepatocyte-specific miR-100 deficient mice.…”

DataSheet_2_Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.xlsx by Yingdong Han (11904761)

“…However, the causality and the direction of the associations remain unknown. Thus, we performed a two-sample bidirectional Mendelian Randomization (MR) analysis to investigate the causal association between uric acid and 25-hydroxyvitamin D and to determine the direction of the association.…”

Table_2_A causal examination of the correlation between hormonal and reproductive factors and low back pain.xlsx by Dafu Chen (291913)

Different Growth and Physiological Responses to Cadmium of the Three <i>Miscanthus</i> Species by Haipeng Guo (582824)

“…<i>Miscanthus sinensis</i> showed more sensitivity to Cd, including sharp decreases in growth, Pn, PEPC activity and damage to chloroplast structure, and the highest H₂O₂ and Cd concentrations in leaves and roots after Cd treatments. …”

Image_2_Reassessing Particulate Organic Carbon Dynamics in the Highly Disturbed San Francisco Bay Estuary.TIF by Peter J. Hernes (8640351)

“…Across the ∼20-year span, we detected (1) decreasing C:N_a ratios (averages ± SD of 12.5 ± 2.5 vs. 8.8 ± 1.4, significant t-test with p < 0.0001); (2) distinct shifts in chlorophyll vs. salinity, with higher chlorophyll concentrations shifting toward freshwater; and (3) greater relative proportions of vascular plant carbon that also appears less degraded (as indicated by lignin measurements) shifting from freshwater toward higher salinities. …”

Table_1_Differences in SARS-CoV-2-Specific Antibody Responses After the First, Second, and Third Doses of BNT162b2 in Naïve and Previously Infected Individuals: A 1-Year Observatio... by Manca Ogrič (12696659)

“…</p>Methods<p>We measured anti-spike (anti-S) and anti-nucleocapsid antibodies at different time points up to 12 months in the sera of 300 HCP who had received two or three doses of BNT162b2 vaccine. …”

DataSheet_1_Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure.pdf by Ling Guo (9700)

“…In this prospective study, comprehensive bioinfomatic analysis and logistic regression analysis were used to compare the serum cytokine profiles of 41 RIF patients with those of 29 subjects with first-cycle successful pregnancy in the mid-luteal phase and to assess the alterations of cytokine profiles in patients with clinical pregnancy at five weeks post-transplantation. We found several elevated pro-inflammatory cytokines, decreased anti-inflammatory cytokines, and increased Th1/Th2 cytokine ratios in RIF patients compared to control subjects. …”

Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a Protein by Chao Fu (63060)

“…Importantly, we revealed that homer1a in D₂ receptor neurons enhances AMPA receptors expression.…”

Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a Protein by Chao Fu (63060)

“…Importantly, we revealed that homer1a in D₂ receptor neurons enhances AMPA receptors expression.…”

Table_1_Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response.docx by Ning Yu (358970)

“…We demonstrated a significant increase in IL-1β production from GPP monocytes. …”

Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene <i>PER2</i> expression by Kristina Hasakova (7553306)

“…From <i>in silico</i> analysis, miR-34a-5p was selected as showing a computer-predicted interaction with <i>PER2</i>. Real-time PCR revealed a negative correlation between expression of <i>PER2</i> mRNA and miR-34a in patients with more advanced cancer stage. …”

Image_1_Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response.tif by Ning Yu (358970)

“…We demonstrated a significant increase in IL-1β production from GPP monocytes. …”

Screening flowchart. by Xuechun Fan (5439470)

“…<div><p>Introduction</p><p>Diabetic peripheral neuropathy (DPN), a prevalent complication among individuals diagnosed with type 2 diabetes, has a significant impact on both the well-being of patients and their financial situation. …”