table1_Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats.docx by Fanyuan Zhou (10431314)

“…However, the underlying mechanism has not been well elucidated. In the present study, we measured the markers of apoptosis, inflammation, oxidative stress, and nuclear factor erythroid 2–related factor 2 (Nrf2) signaling to investigate the effects of JPYS formula on renal function and fibrosis and its molecular mechanism in an established animal model of 5/6 nephrectomized (5/6Nx) rats. …”

A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models by Hao Zhang (15339)

“…However, the mTOR kinase exists in two distinct multiprotein complexes, mTORC1 and mTORC2, and both complexes may be critical regulators of cell metabolism, growth and proliferation. …”

Antimicrobial nano-zinc oxide-2S albumin protein formulation significantly inhibits growth of “<i>Candidatus</i> Liberibacter asiaticus” in planta by Dilip Kumar Ghosh (5843651)

“…The dynamics of <i>C</i>Las pathogen load of treated Mosambi plants was assessed using TaqMan-qPCR assay every 30 days after treatment (DAT) and monitored till 120 days. We observed that 2S albumin-Nano-ZnO formulation performed the best among all the treatments decreasing <i>C</i>Las population by 96.2%, 97.6%, 95.6%, and 97% of the initial bacterial load (per 12.5 ng of genomic DNA) at 30, 60, 90, and 120 DAT, respectively. …”

Data Sheet 2_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.pdf by Miguel Ângelo-Dias (20936444)

“…</p>Methods<p>A total of 50 pregnant and 30 age-matched non-pregnant women were recruited in a prospective cohort study. …”

Table_1_Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist.docx by Rakesh Kumar Pilania (9774821)

“…In this review, we describe the evolving clinical phenotypes of DADA2 with a special focus on haematological and immunological manifestations.…”

Image2_Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms.TIF by Talita Glaser (302466)

Image_2_Bidirectional Mendelian randomization study of insulin-related traits and risk of ovarian cancer.png by Xinghao Wang (802907)

“…</p>Results<p>Among all insulin related indicators (fasting insulin level, insulin secretion rate, peak insulin response), the insulin secretion rate was selected to have a causal relationship with the occurrence of ovarian cancer (IVW, P < 0.05), that is, the risk of ovarian cancer increased with the decrease of insulin secretion rate. At the same time, we tested the heterogeneity and polymorphism of this indicator, and the results were non-existent, which ensured the accuracy of the analysis results. …”

Table_2_Lipid-lowering medications and risk of malignant melanoma: a Mendelian randomization study.xlsx by BoWen Yang (18861130)

“…</p>Methods<p>Genetic variations within an LDL-related drug target gene (LDL-cholesterol from a genome-wide association study) served as proxies for exposure to lipid-lowering drugs. We conducted a two-sample Mendelian randomization analysis using inverse variance weighting (IVW), MR-Egger, and weighted median approaches. …”

Image_1_Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis.JPEG by Louis Koeninger (8384061)

“…Suppression of LPS-induced inflammation was dependent on chemokine receptor 2 (CCR2) expression. Mechanistically, hBD2 engaged with CCR2 on its DC target cell to decrease NF-κB, and increase CREB phosphorylation, hence curbing inflammation. …”

Table_2_Modeling of the Potential Geographical Distribution of Three Fritillaria Species Under Climate Change.xls by Ruiping Jiang (11924855)

“…The niche overlap of three Fritillaria species was related to the phylogenetic analysis despite the non-significance (P > 0.05), indicating that spatial distribution was one of the factors that contributed to the speciation diversification. Additionally, we predicted species-specific habitats to decrease habitat competition. …”

data_sheet_2_Lipidomic Impacts of an Obesogenic Diet Upon Lewis Lung Carcinoma in Mice.xlsx by Sneha Sundaram (651300)

“…In order to gain further insights into the mechanisms by which dietary fats impact cancer progression, we conducted a lipidomic analysis of primary tumors originated from LLC from mice fed with a standard AIN93G diet or a soybean oil-based high-fat diet (HFD). …”

Image_2_Bacterial community responses of the hydrothermal vent crab Xenograpsus testudinatus fed on microplastics.jpeg by Priyanka Muthu (16911093)

Ghrelin Protects against Renal Damages Induced by Angiotensin-II via an Antioxidative Stress Mechanism in Mice by Keiko Fujimura (586386)

“…The transfection of UCP2 siRNA abolished the decrease in mitochondria-derived ROS by Ghrelin. …”

Table_2_Dynamic immune and exosome transcriptomic responses in patients undergoing psychostimulant methamphetamine withdrawal.XLSX by Hongjin Wu (592092)

Data_Sheet_2_Salt Marsh and Tidal Flat Area Distributions Along Three Estuaries.PDF by Maarten G. Kleinhans (3297036)

Data_Sheet_2_Overexploitation, Recovery, and Warming of the Barents Sea Ecosystem During 1950–2013.PDF by Torstein Pedersen (11447782)

Image_1_Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist.tiff by Rakesh Kumar Pilania (9774821)

“…In this review, we describe the evolving clinical phenotypes of DADA2 with a special focus on haematological and immunological manifestations.…”

Data_Sheet_1_Investigating functional brain connectivity patterns associated with two hypnotic states.PDF by Nuno M. P. de Matos (17669874)

“…In this fMRI study (which is part of a larger hypnosis project) with 50 hypnosis-experienced participants, we analyzed neural and physiological responses during two hypnosis states, comparing them to non-hypnotic control conditions and to each other. …”

Supplementary Material for: Stage-Specific Effects of Fibroblast Growth Factor 2 on the Differentiation of Dental Pulp Cells by Sagomonyants K. (4150690)

“…To gain a better insight into the role of FGF2 in dentinogenesis, we used dental pulp cells from various transgenic mice, in which fluorescent protein expression identifies cells at different stages of odontoblast differentiation. …”

Image2_Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases.pdf by Kennedy Bonjour (5490656)