GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) by F. Anthony Romero (2452198)

“…In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. …”

Revisiting the sealed heating method–V158411 decreases Chk1 nuclear immunofluorescence in HT29 cells heated in a low well volume. by Andrew J. Massey (239469)

S2 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

Serum samples and 50% NAI values. Serum samples taken from CEIRS study. by Harrison Powell (9040128)

DataSheet2_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

The Non-Catalytic Domains of <i>Drosophila</i> Katanin Regulate Its Abundance and Microtubule-Disassembly Activity by Kyle D. Grode (725568)

“…Our data indicate that the microtubule-interacting and trafficking (MIT) domain and adjacent linker region of the <i>Drosophila</i> katanin catalytic subunit Kat60 cooperate to regulate microtubule severing in two distinct ways. First, the MIT domain and linker region of Kat60 decrease its abundance by enhancing its proteasome-dependent degradation. …”

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. by Hope Murphy (8843516)

Multiple logistic regression model exploring factors associated with >50% seizures reduction at month 4. by Michel Mandro (2637532)

Simultaneous silencing of isoamylases ISA1, ISA2 and ISA3 by multi-target RNAi in potato tubers leads to decreased starch content and an early sprouting phenotype by Stephanus J. Ferreira (4249219)

“…Here, we created transgenic potato plants with simultaneously decreased expression of all three isoamylases using a chimeric RNAi construct targeting all three isoforms. …”

Different Association of Human Papillomavirus 16 Variants with Early and Late Presentation of Cervical Cancer by Ana Alfaro (280118)

“…Remarkably, this risk was higher for ACC (OR = 6.0, 95% CI = 1.1–33, p < 0.05) than for SCC (OR = 2.8, 95% CI = 1.3–5.9, p < 0.01). Interestingly, when analyzing only the HPV16-positive CC, D2 increases (OR = 2.5, 95% CI = 1.2–5, p < 0.05) and D3 decreases (OR = 0.45, 95% CI 0.2–0.9, p < 0.05) the risk to develop CC before 50 years old in relation with A1/2 variant. …”

Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX by Hong Zhang (25820)

“…However, EMPA did specifically decrease cardiac lactate labeling in the ¹³C glucose perfusions (¹³C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …”

DataSheet_1_Interventions to Decrease Carotid-Intima Media Thickness in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-Analysis.docx by Adina Mihaela Epure (9673974)

“…CIMT measurement was rated at a higher quality on all reliability domains in 3 (50%) studies. …”

The PRAME-AS knockout cells showed a decrease in migration, proliferation, stemness, and viability. by Zahra Hosseininia (22265113)

The decrease in blood flow disrupts CV pruning. by Lin Wen (557398)

Image_1_Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4.TIF by Tamara Moreno-Sosa (10717320)

The phosphorylation sites we identified in both ULK1 and ATG13 are conserved between different isoforms. by Zhiyuan Li (205620)

ChAT knock-down using an antisense oligodeoxynucleotide (AS-ODN) against ChAT, and decreased expression of ChAT in the DRG and spinal cord by Misaki Matsumoto (52354)

Exercise test characteristics for identifying stenosis ≥ 50% in any limb among the 60 limbs with normal ABIs (> 0.91). by O. Stivalet (6890189)

<i>In vivo</i> expression of EAC3I decreases s/mEPSC frequency in dorsal lateral striatum MSNs. by Jason R. Klug (132807)

The primers related to FAM50A. by Longhai Li (4052044)

“…Knockdown of FAM50A decreased cell proliferation ability, the proportion of EdU positive cells, and the number of CRC cell colonies, whereas overexpressing FAM50A promoted proliferative phenotypes. …”