Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Resveratrol decreases cell proliferation in a time and dose dependent manner. by Mehtap Kilic Eren (591048)

Development of a cAMP sensor with decreased pH sensitivity. by Katy L. Everett (461878)

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…The complexes demonstrated submicromolar cytotoxic activity against human breast cancer cells MDA-MB-231 or MDA-MB-468 with IC₅₀’s in the range of 0.4–5.0 μM. Complex <b>2e</b> shows high potency in vitro and decreases 3D-breast cancer mammosphere viability. …”

Emerging Disinfection Byproduct 2,6-Dichlorobenzoquinone-Induced Cardiovascular Developmental Toxicity of Embryonic Zebrafish and Larvae: Imaging and Transcriptome Analysis by Xue Yang (144876)

“…In this study, we examined the effects of an aromatic DBP, 2,6-dichlorobenzoquinone (DCBQ), on the cardiovascular development of zebrafish embryos. …”

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric <i>in silico</i> ROCOCO trial by Daniëlle B. P. Eekers (5560430)

Average time necessary to disperse 50% of the population introduced (half-life time) in experiments and theoretical simulations, according to the number of woodlice initially intro... by Pierre Broly (228993)

Effect of DE of <i>S. malaccense</i> and <i>S. samarangense</i> leaves on A) ATP, B) p-mTOR, C) beclin-1, and D) p-AMPK levels. by Fatma A. Moharram (9276104)

Subjects:

Effect of different doses of the defatted extract (DE) of the leaves of <i>S. malaccense</i> and <i>S. samarangense</i> on urea and creatinine levels. Data represented as mean±SEM... by Fatma A. Moharram (9276104)

Subjects:

Effect of DE of <i>S. malaccense</i> and <i>S. samarangense</i> leaves on histopathological examination of the kidney tissues. by Fatma A. Moharram (9276104)

Subjects:

Estimated total phenolic content (TPC), and total flavonoid content (TFC) in the defatted extract (DE) of <i>S. malaccense</i> and <i>S. samarangense</i> leaves. by Fatma A. Moharram (9276104)

Subjects:

Effect of DE of <i>S. malaccense</i> and <i>S. samarangense</i> on A) GSH, B) SOD, C) TNF-α, D) IL-1β, E) p-NF-κB, and F) Caspase-3 levels. by Fatma A. Moharram (9276104)

Subjects:

Effect of different doses (mg/Kg) of the defatted extract (DE) of the leaves of <i>S. malaccense</i> and <i>S. samarangense</i> on serum ALT and AST levels. Data represented as mea... by Fatma A. Moharram (9276104)

Subjects:

Drugs IC₅₀s data during the study period. by Winnie Okore (14139712)

Diversity of intestinal microbiota in the feces of finishing pigs fed a diet supplemented with or without <i>B</i>. by Jun Ho Song (1675123)

Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year Follow-up of the Qidong Hepatitis B Intervention Study: A Cluster Randomized Controlled T... by Chunfeng Qu (114656)

“…The participation rates of the two surveys were 57.5% (21,770) and 50.7% (17,204) in the vaccination group and 36.3% (12,184) and 58.6% (17,395) in the control group, respectively. …”

Immunization for EAE decreased the counts of CD4+ and CD8+ T-PBLs in DA rats. by Mirjana Nacka-Aleksić (3342095)