Reduced D2/D3 Receptor Binding of Extrastriatal and Striatal Regions in Temporal Lobe Epilepsy by Viviane E. Bernedo Paredes (823518)

“…In animal models of temporal lobe epilepsy (TLE), seizure threshold is modulated to some extent by dopamine, with D1-receptors having a pro- and D2-receptors an anticonvulsant effect. We aimed to extend our previously reported results on decreased D2/D3 receptor binding in the lateral epileptogenic temporal lobe and to correlate them with demographic and seizure variables to gain a more comprehensive understanding of the underlying involvement of the dopaminergic system in the epileptogenesis of TLE.…”

Presentation1_P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.pdf by Robin M. H. Rumney (4672501)

“…To investigate the role of P2X7 in dystrophic calcification, we utilised the Dmd^mdx-βgeo dystrophin-null mouse model of DMD crossed with a global P2X7 knockout (P2rx7^−/−) or with our novel P2X7 knockin-knockout mouse (P2x7^KiKo), which expresses P2X7 in macrophages but not muscle cells. …”

Table2_Network Meta-Analysis of Different Intravenous Glucocorticoid Regimes for the Treatment of Graves’ Orbitopathy.DOCX by Jun Jia (112173)

“…<p>Background: Intravenous glucocorticoid (GC) has been proposed to treat moderately severe Graves’ orbitopathy (GO); however, the optimal regime remains debatable. We therefore performed this network meta-analysis to objectively determine the comparative efficacy and safety of different intravenous GC regimes, including daily, weekly, or monthly intravenous regimes, for the treatment of GO.…”

Video3_P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.AVI by Robin M. H. Rumney (4672501)

“…To investigate the role of P2X7 in dystrophic calcification, we utilised the Dmd^mdx-βgeo dystrophin-null mouse model of DMD crossed with a global P2X7 knockout (P2rx7^−/−) or with our novel P2X7 knockin-knockout mouse (P2x7^KiKo), which expresses P2X7 in macrophages but not muscle cells. …”

Image_2_mTOR Promotes Tissue Factor Expression and Activity in EGFR-Mutant Cancer.JPEG by Ying Cong (1985428)

“…Both the mTOR- and TF-targeted therapy induced a multifaceted remodeling of tumor microenvironment reflecting not only a diminished hypercoagulopathy state (fibrin level) but also a reduced stromal fibrosis (collagen distribution), compromised vessel density and/or maturity (CD31 and/or α-SMA) as well as a substantially decreased infiltration of immune-suppressive M2-type tumor-associated macrophages (CD206/F4/80 ratio). …”

Role of PU.1 in MHC Class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells by Ryosuke Miura (2623387)

“…The introduction of PU.1 siRNA into mouse pDCs and a human pDC cell line, CAL-1, reduced the mRNA levels of MHC class II and CIITA. When the binding of PU.1 to the 3rd promoter of CIITA (pIII) in CAL-1 and mouse pDCs was analyzed by a chromatin immunoprecipitation assay, a significant amount of PU.1 binding to the pIII was detected, which was definitely decreased in PU.1 siRNA-transfected cells. …”

Table 2_Increasing vulnerability of an endemic Mediterranean-climate conifer to changing climate and fire regime.xlsx by Frank W. Davis (8218293)

“…We also modeled the distribution of Quercus chrysolepis (CLO), a widespread oak that can be co-dominant with BDF and that can limit fire spread and reduce crown fire risk to BDF compared to the risk from surrounding chaparral vegetation. …”

Table_1_miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease.DOCX by Sara R. Oliveira (10972152)

“…In conclusion, we revealed novel roles for miR-335 in both microglia and neuronal cells that strongly halt the effects of classical inflammatory stimuli or LRRK2-Wt overexpression, thus attenuating chronic neuroinflammation.…”

Image_2_Effect of β-Hydroxybutyrate on Autophagy Dynamics During Severe Hypoglycemia and the Hypoglycemic Coma.TIF by Carmen Torres-Esquivel (9408707)

“…D-BHB treatment reduced LC3-II and SQSTM1/p62 content and reduced ULK1 phosphorylation by AMPK, suggesting it stimulates the autophagic flux and decreases AMPK activity reducing autophagy initiation. …”

Serological signatures of declining exposure following intensification of integrated malaria control in two rural Senegalese communities by Ronald Perraut (366061)

“…We analyse here serological signatures of declining transmission using archived blood samples. …”

Table 2_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx by Jingjing Chen (293564)

“…Ribosome biogenesis, critical for cellular homeostasis, is hypothesized to drive placental dysfunction in PE, though its role remains underexplored.</p>Methods<p>We integrated placental transcriptomic data from two datasets (GSE75010, GSE10588) to systematically investigate ribosome biogenesis dysregulation in preeclampsia. …”

Image_2_Streptococcus mutans Secreted Products Inhibit Candida albicans Induced Oral Candidiasis.JPEG by Jéssica Diane dos Santos (9125237)

“…Active S. mutans UA159 supernatant filtrate components were extracted via liquid-liquid partition and fractionated on a C-18 silica column to resolve S. mutans fraction 1 (SM-F1) and fraction 2 (SM-F2). We found anti-biofilm activity for both SM-F1 and SM-F2 in a dose dependent manner and fungal growth was reduced by 2.59 and 5.98 log for SM-F1 and SM-F2, respectively. …”

Table_1_The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy.pdf by Simone Pickel (11086605)

“…We report that a pool of Ca_vβ₂ is targeted to the nucleus in cardiomyocytes and that the expression of this nuclear fraction decreases during in vitro and in vivo induction of cardiac hypertrophy. …”

Video1_P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.AVI by Robin M. H. Rumney (4672501)

“…To investigate the role of P2X7 in dystrophic calcification, we utilised the Dmd^mdx-βgeo dystrophin-null mouse model of DMD crossed with a global P2X7 knockout (P2rx7^−/−) or with our novel P2X7 knockin-knockout mouse (P2x7^KiKo), which expresses P2X7 in macrophages but not muscle cells. …”

Image_2_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway Is Required for Endometrial Decidualization in Mice and Human by Chae Hyun Lee (462526)

“…To determine the role and regulation of ERK1/2 signaling during implantation and decidualization, we examine ERK1/2 signaling in the mouse uterus during early pregnancy using immunostaining and qPCR. …”

Image_2_Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer.tif by Jiannan Xu (12282551)

Self-levelling gypsum paste for use as a subfloor layer by Daniel Bruno Pinto da Silva (10410931)

“…A dosage study was carried out on pastes containing a water-to-gypsum ratio of 0.35; 0.40; 0.45; 0.475; 0.50, and 0.55 along with the superplasticizer additive content adjusted for self-levelling spreading. …”

Mean displacement decay power around a single cell. by Chrysovalantou Kalaitzidou (18946434)

“…Decay power decreases almost linearly with contraction, at least for contraction levels that reach 50%, for Family-1 models apart from <i>Sλ</i> = λ⁷ − 1. …”

Image_2_Immune Monitoring Assay for Extracorporeal Photopheresis Treatment Optimization After Heart Transplantation.pdf by Maja-Theresa Dieterlen (6254165)

“…</p>Results<p>All BDCA⁺ DC subsets (BDCA1⁺ DCs: p < 0.01, BDCA2⁺ DCs: p < 0.01, BDCA3⁺ DCs: p < 0.01, BDCA4⁺ DCs: p < 0.01) as well as total T_regs(p < 0.01) and CD39⁺ T_regs(p < 0.01) increased during ECP treatment, while CD62L⁺ T_regs decreased (p < 0.01). …”