Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…In this report, we describe the design, synthesis, and biological evaluation of sphingosine kinase 2 (SphK2) inhibitors with a focus on systematically introducing rigid structures in the aliphatic lipid tail present in existing SphK2 inhibitors. …”

Image_2_Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies.jpeg by Nivedita M. Ratnam (11139741)

“…This paucity of TILs is in concert with the finding of epigenetic silencing of genes that promote immune cell movement (chemotaxis) to the tumor. In this study we evaluated the ability of GSK126, a blood-brain barrier (BBB) permeable small molecule inhibitor of EZH2, to reverse GBM immune evasion by epigenetic suppression of T cell chemotaxis. …”

Image_2_GPR15 in colon cancer development and anti-tumor immune responses.jpeg by Hong Namkoong (16898)

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…In this report, we describe the design, synthesis, and biological evaluation of sphingosine kinase 2 (SphK2) inhibitors with a focus on systematically introducing rigid structures in the aliphatic lipid tail present in existing SphK2 inhibitors. …”

Image_2_CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma.tif by Chenhui Cai (11475433)

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…In this report, we describe the design, synthesis, and biological evaluation of sphingosine kinase 2 (SphK2) inhibitors with a focus on systematically introducing rigid structures in the aliphatic lipid tail present in existing SphK2 inhibitors. …”

A mathematical model of <i>Clostridium difficile</i> transmission in medical wards and a cost-effectiveness analysis comparing different strategies for laboratory diagnosis and pat... by Vered Schechner (3740008)

“…For each strategy, we calculated the annual cost (of CDI diagnosis and isolation) for a decrease of 1 in the average daily number of CDI patients; the strategy of the two-step test and contact isolation in multiple-bed rooms was the reference strategy.…”

Table_5_Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants.pdf by Ye-Fan Hu (10307357)

“…We visualized all 1,521 SARS-CoV-2 lineages to indicate variants including Mu, B.1.630, B.1.633, B.1.649, and C.1.2, which can induce vaccine breakthrough infections in addition to reported VOCs Beta, Gamma, Delta, and Omicron. …”

Table_3_Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants.pdf by Ye-Fan Hu (10307357)

“…We visualized all 1,521 SARS-CoV-2 lineages to indicate variants including Mu, B.1.630, B.1.633, B.1.649, and C.1.2, which can induce vaccine breakthrough infections in addition to reported VOCs Beta, Gamma, Delta, and Omicron. …”

Table_1_Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants.pdf by Ye-Fan Hu (10307357)

“…We visualized all 1,521 SARS-CoV-2 lineages to indicate variants including Mu, B.1.630, B.1.633, B.1.649, and C.1.2, which can induce vaccine breakthrough infections in addition to reported VOCs Beta, Gamma, Delta, and Omicron. …”

Physiological effect of cleavage of periostin by MMP9 on IMCD-3 cell proliferation. by Nabila Djaziri (17537499)

“…(B, C) Representative Western Blot and quantitative analysis showing that periostin level is decreased by 50% after incubation with activated MMP9 overnight. …”

Image_2_Neutralizing Anti-Rituximab Antibodies and Relapse in Membranous Nephropathy Treated With Rituximab.TIFF by Sonia Boyer-Suavet (8291778)

“…Antibody titer is correlated with disease activity: rising during active disease and decreasing before remission. Therefore, decreasing PLA2R1-Antibodies titer has become an important goal of therapy. …”

Fluoride rinse effect on retention of CaF2 formed on enamel/dentine by fluoride application by Amanda FALCÃO (12806110)

“…We tested the effect of twice daily 0.05% NaF rinses on the retention of “CaF2” formed on enamel and dentine after applying acidulated phosphate fluoride (APF). …”

Altered balance of catabolic/anabolic carbon metabolism in Δ<i>hyd</i>2 cells. by Chris Greening (603810)

“…There is an increased flux though the tricarboxylic acid cycle due to upregulation of enzymes involved in oxidative decarboxylation (e.g. ketoglutarate-ferredoxin oxidoreductase) (highlighted in yellow) and downregulation of those involved in anaplerosis (i.e. isocitrate lyase) (highlighted in blue). We model that loss of CO₂ through oxidative decarboxylation reactions is principally responsible for the decreased biomass of Δ<i>hyd</i>2 cells. …”

Energy budget calculation for two strategies to cope with reduced energy intake during foraging activity. by Roelof A. Hut (226122)

ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment by William B. Hamilton (403021)

“…<div><p>Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES) cells to exit self-renewal and commit to early differentiated lineages. Here we show that genetic ablation of <i>Erk2</i>, the predominant ERK isozyme expressed in ES cells, results in hyper-phosphorylation of ERK1, but an overall decrease in total ERK activity as judged by substrate phosphorylation and immediate-early gene (IEG) induction. …”

Image_2_State-Dependent and Bandwidth-Specific Effects of Ketamine and Propofol on Electroencephalographic Complexity in Rats.TIF by Michael A. Brito (9226880)

“…Phase-shuffled normalized LZc revealed that (1) decrease in complexity during ketamine and propofol anesthesia—not increase in complexity during emergence—were dissociable from the influence of spectral changes, and (2) reduced LZc during ketamine anesthesia was present across all three bandwidths. …”

DataSheet2_Equilibration Times of Dissolved Inorganic Carbon During pH Transitions.DOCX by Ziv Sade (11953526)

“…We approximate the equilibration degree of the DIC reservoir by the smaller of the CO₂(aq) and S pools at the new pH, since the smaller pool is always farther from equilibrium during the chemical evolution. …”

A Three-Pronged Attack To Investigate the Electronic Structure of a Family of Ferromagnetic Fe₄Ln₂ Cyclic Coordination Clusters: A Combined Magnetic Susceptib... by Sebastian F. M. Schmidt (3816781)

“…We present the synthesis, structure, magnetic properties, as well as the Mössbauer and electron paramagnetic resonance studies of a ring-shaped [Fe^III₄Ln^III₂­(Htea)₄­(μ-N₃)₄(N₃)₃­(piv)₃] (Ln = Y <b>1</b>, Gd <b>2</b>, Tb <b>3</b>, Dy <b>4</b>, Ho <b>5</b>, Er, <b>6</b>) coordination cluster. …”

A Three-Pronged Attack To Investigate the Electronic Structure of a Family of Ferromagnetic Fe₄Ln₂ Cyclic Coordination Clusters: A Combined Magnetic Susceptib... by Sebastian F. M. Schmidt (3816781)

“…We present the synthesis, structure, magnetic properties, as well as the Mössbauer and electron paramagnetic resonance studies of a ring-shaped [Fe^III₄Ln^III₂­(Htea)₄­(μ-N₃)₄(N₃)₃­(piv)₃] (Ln = Y <b>1</b>, Gd <b>2</b>, Tb <b>3</b>, Dy <b>4</b>, Ho <b>5</b>, Er, <b>6</b>) coordination cluster. …”