Multilevel Proteomic Profiling of Colorectal Adenocarcinoma Caco‑2 Cell Differentiation to Characterize an Intestinal Epithelial Model by Emily Ef Fekete (18693156)

“…However, its suitability to study such interactions remains to be characterized. Here, we employed multilevel proteomics to demonstrate that both spontaneous and butyrate-induced Caco-2 differentiations displayed similar protein and pathway changes, including the downregulation of proteins related to translation and proliferation and upregulation of functions implicated in host–microbiome interactions, such as cell adhesion, tight junction, extracellular vesicles, and responses to stimuli. …”

Multilevel Proteomic Profiling of Colorectal Adenocarcinoma Caco‑2 Cell Differentiation to Characterize an Intestinal Epithelial Model by Emily Ef Fekete (18693156)

“…However, its suitability to study such interactions remains to be characterized. Here, we employed multilevel proteomics to demonstrate that both spontaneous and butyrate-induced Caco-2 differentiations displayed similar protein and pathway changes, including the downregulation of proteins related to translation and proliferation and upregulation of functions implicated in host–microbiome interactions, such as cell adhesion, tight junction, extracellular vesicles, and responses to stimuli. …”

Multilevel Proteomic Profiling of Colorectal Adenocarcinoma Caco‑2 Cell Differentiation to Characterize an Intestinal Epithelial Model by Emily Ef Fekete (18693156)

“…However, its suitability to study such interactions remains to be characterized. Here, we employed multilevel proteomics to demonstrate that both spontaneous and butyrate-induced Caco-2 differentiations displayed similar protein and pathway changes, including the downregulation of proteins related to translation and proliferation and upregulation of functions implicated in host–microbiome interactions, such as cell adhesion, tight junction, extracellular vesicles, and responses to stimuli. …”

Multilevel Proteomic Profiling of Colorectal Adenocarcinoma Caco‑2 Cell Differentiation to Characterize an Intestinal Epithelial Model by Emily Ef Fekete (18693156)

“…However, its suitability to study such interactions remains to be characterized. Here, we employed multilevel proteomics to demonstrate that both spontaneous and butyrate-induced Caco-2 differentiations displayed similar protein and pathway changes, including the downregulation of proteins related to translation and proliferation and upregulation of functions implicated in host–microbiome interactions, such as cell adhesion, tight junction, extracellular vesicles, and responses to stimuli. …”

Csf1r and Mer expression further define KC subsets in mouse liver. by Juan A. Santamaria-Barria (6655667)

Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells by Juan A. Santamaria-Barria (6655667)

“…At 36h after PH, Csf1r inhibition increased serum ALT and histological liver injury, and decreased liver cell proliferation. A small molecule inhibitor of Mer did not alter the percentage of KCs or their proliferation and just modestly delayed LR. …”

How the Layer Alignment in Two-Dimensional Nanoporous Covalent Organic Frameworks Impacts Its Electronic Properties by Kuber Singh Rawat (13823696)

“…Two-dimensional nanoporous covalent organic frameworks (2D COFs) have gathered significant interest due to their wide range of applications. …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

How the Layer Alignment in Two-Dimensional Nanoporous Covalent Organic Frameworks Impacts Its Electronic Properties by Kuber Singh Rawat (13823696)

“…Two-dimensional nanoporous covalent organic frameworks (2D COFs) have gathered significant interest due to their wide range of applications. …”

Source data for main figure graphs in this study. by Kristen L. Lokken-Toyli (9455263)

“…Expression of many such genes was also decreased in early life in humans. Infant mice also showed increased URT barrier permeability and delayed mucociliary clearance during the first two weeks of life, which corresponded with tighter attachment of bacteria to the respiratory epithelium. …”

Involvement of COX-2/PGE2 signaling in proliferation of A549 cells. by Erina Takai (465811)

“…<p>(A) A549 cells were incubated with NS-398 (50 µM) for 3 days and the cell cycle was analyzed as described in Materials and Methods. …”

Image_1_Healthcare Workers in South Korea Maintain a SARS-CoV-2 Antibody Response Six Months After Receiving a Second Dose of the BNT162b2 mRNA Vaccine.jpg by Jae Hong Choi (3339120)

“…Background<p>Effective vaccines against coronavirus disease 2019 (COVID-19) are available worldwide; however, the longevity of vaccine effectiveness is not known.</p>Objective<p>We performed a prospective observational study to assess the antibody response of healthcare workers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after BNT162b2 mRNA COVID-19 vaccination.…”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. …”

Kinetics and dose response of distinct changes to HDMEC barriers induced by TNF and IL-β. by Paul R. Clark (714064)

“…A plot of the percent increase over basal TEER values (measured at the peak of the TNF-induced TEER increase, mean 0.7±0.01 hours; y-axis) vs. basal TEER (reported in ohms and read on a 96W20idf ECIS array; x-axis). …”