Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis حسب Smatti, Maria K.

"…Methods: We extracted the list of SNPs that could potentially modulate SARS-CoV-2 from the genome wide association studies (GWAS) on SARS-CoV-1 and other viruses. …"
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Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. حسب Smatti, Maria K

"…We extracted the list of SNPs that could potentially modulate SARS-CoV-2 from the genome wide association studies (GWAS) on SARS-CoV-1 and other viruses. …"
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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria حسب Al-Sadeq, Duaa W.

"…In this study, we present the clinical and biochemical characterization of two novel CBS missense mutations that do not respond to pyridoxine treatment, namely c.689T > A (L230Q) and 215A > T (K72I), identified in a Chinese patient. …"
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Enhancement of Ethanol Production in Electrochemical Cell by Saccharomyces cerevisiae (CDBT2) and Wickerhamomyces anomalus (CDBT7) حسب Joshi J.

"…In that regard, in the present study, we have used two highly efficient ethanol producing yeast strains, viz., Saccharomyces cerevisiae (CDBT2) and Wickerhamomyces anomalous (CDBT7), in an electrochemical cell to enhance ethanol production. …"
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The Cardiovascular Benefits of Empagliflozin, A Sodium Glucose Cotransporter Inhibitor: Is NHE1 a Viable Target? حسب Al-Shamasi, Al-Anood

"…We characterized H9c2 cardiomyoblasts stimulated with Angiotensin II (ANG II) 100nM in the presence and absence of EMPA (500nM) and measured cardiomyocyte hypertrophy and the expression of NHE1 and SGLT1/2. …"
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Topiramate monotherapy for weight reduction in patients with type 2 diabetes mellitus: A systematic review and meta-analysis حسب Paravattil, Bridget

"…We included randomized controlled trials that evaluated topiramate monotherapy versus control agents or placebo for weight loss in obese type 2 diabetes patients. …"
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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS حسب Hourani, Shireen Bayan

"…The autophagy p62 gene was 61% upregulated, whereas the ATG and LC3-activated cells were lower by 33% at the protein level and 78.3% by flowcytometry, respectively. Nonetheless, CYP3A4, and CYP2D6 were lower in CSCs by 75%, 23%, 43%, 23.8%, and 17%, respectively. …"
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The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes. حسب Al-Asmakh, Maha

"…The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. …"
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Local supersaturation and the growth of protective scales during CO2 corrosion of steel: Effect of pH and solution flow حسب Sk, Mobbassar Hassan

"…We show that siderite is the first crystalline product and that chukanovite follows, with a delay time that decreases with increasing pH. …"
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Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome. حسب Thirumal Kumar, D

"…In the simulations, we observed decreased deviation and fluctuations in native NOD2, whereas decreased compactness and inter- and intramolecular hydrogen bonds were observed in the W490L mutant. …"
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Co-doped zigzag graphene nanoribbon based gas sensor for sensitive detection of H2S: DFT study حسب Salih, Ehab

"…In this work, we present a highly sensitive gas sensor for the detection of poisonous hydrogen sulfide gas (H2S) based on copper and zinc co-doped zigzag graphene nanoribbon (Cu/Zn-ZGNR). …"
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Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling حسب Ibrahim, Khadega

"…Compared to RSG group, the combined treatment group stimulates osteoblastogenesis, as evidenced by increased mineralization and upregulation of osteogenic markers OPN and RUNX2 and inhibits adipogenesis in osteogenic media as showed by decreased lipid content and downregulation of adipogenic markers FABP4, LPL and adipsin. …"
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Aqueous Extract Of Origanum Syriacum Inhibits Proliferation, Migration, Adhesion As Well As Erk1/2 Phosphorylation In Aggressive Breast Cancer حسب Al Kahlout, Amal

"…Moreover, preliminary results indicate that OSE decreased ERK1/2 phosphorylation in MDA-MB-231 cells. …"
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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress حسب Fatima, Munazza T

"…We found that SESN2 silencing, though did not specifically induce ER stress, it aggravated the effects of thapsigargin-induced ER stress on oxidative stress and cell survival. …"
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Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach. حسب Thirumal Kumar, D

"…From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex. …"
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Micromodel Study on Colloid Retention and Mobilization under different Geo-Chemical Conditions during Single and Two-Phase Flow حسب Nishad, Safna

"…Micromodels are analogs to porous media that allow the real-time visualization of pore-scale processes that occur at highly controllable physio-chemical conditions in the laboratory scale. In this thesis, we used a glass micromodel with representative geometry to observe the pore-scale mechanisms during colloid retention and mobilization experiments in a saturated and unsaturated porous media. …"
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes حسب Abushanab, Dina

"…AimsInsufficient risk factor control can lead to a loss of millions of productivity-adjusted life years (PALYs). We aimed to assess the productivity burden of cardiovascular disease (CVD) in type 2 diabetes (T2D) and examine the potential advantages of enhancing the control of modifiable CVD risk factors in Qatar. …"
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. حسب Akhtar, Sabah

"…SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. In addition, it also upregulates pro-apoptotic protein, Bax. …"
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Work-from-home, electricity, and water: Evidence from COVID-19 in Qatar حسب Bernstein, David H.

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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …"
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