DataSheet2_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) by F. Anthony Romero (2452198)

“…In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. …”

Kat60 lacking the MIT domain does not disassemble microtubules at low levels of accumulation in cells. by Kyle D. Grode (725568)

Kat60 lacking the MIT domain disassembles microtubules at high levels of accumulation in cells. by Kyle D. Grode (725568)

Inducible expression of Kat60 results in measurable microtubule disassembly in our single-cell assay. by Kyle D. Grode (725568)

The Non-Catalytic Domains of <i>Drosophila</i> Katanin Regulate Its Abundance and Microtubule-Disassembly Activity by Kyle D. Grode (725568)

“…Our data indicate that the microtubule-interacting and trafficking (MIT) domain and adjacent linker region of the <i>Drosophila</i> katanin catalytic subunit Kat60 cooperate to regulate microtubule severing in two distinct ways. First, the MIT domain and linker region of Kat60 decrease its abundance by enhancing its proteasome-dependent degradation. …”

PNs, ORNs and LNs response to a short (50 ms) pulse, similar results of Fig 4. by Mario Pannunzi (553941)

Praziquantel treatment does not alter SmLy6A and SmLy6B IgG₁ age distribution profiles, but does decrease antigen-specific IgG₁ reactivity. by Iain W. Chalmers (173561)

BT9 exhibits a dose- and time-dependent cytotoxic effect on medulloblastoma. by Zahra Motahari (6814013)

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. by Hope Murphy (8843516)

Multiple logistic regression model exploring factors associated with >50% seizures reduction at month 4. by Michel Mandro (2637532)

Simultaneous silencing of isoamylases ISA1, ISA2 and ISA3 by multi-target RNAi in potato tubers leads to decreased starch content and an early sprouting phenotype by Stephanus J. Ferreira (4249219)

“…Here, we created transgenic potato plants with simultaneously decreased expression of all three isoamylases using a chimeric RNAi construct targeting all three isoforms. …”

S1 Data - by Finn Egil Skjeldestad (7821716)

Subjects:

A functional PSA mimetic peptide (fPSA) prevents glutamate-induced MAP-2 decrease and concomitant changes in SYN and NCAM synaptic patterns and levels. by María Fernanda Podestá (639243)

“…(B) Quantification of MAP-2 immunoreactive area showed decreased levels 6 h after glutamate exposure; this decrease was prevented by fPSA. …”

Mean reaction times in ms to select the infant or the adult target (± SEM). by Sarah K. C. Holtfrerich (3353693)

Means and standard deviations of the age of mothers, fathers, and children across the seven waves. by Chiara Remondi (15301459)

S1 Data - by Jan Willem Koten (17743224)

“…The mean connectivity decreased to r = 0.09 (95% CI 0.03–0.16) when test-retest reliability and auto-correlations of single time courses were considered, indicating that less than a quarter of connectivity is detectable. …”

Connectivity statistics. by Jan Willem Koten (17743224)

“…The mean connectivity decreased to r = 0.09 (95% CI 0.03–0.16) when test-retest reliability and auto-correlations of single time courses were considered, indicating that less than a quarter of connectivity is detectable. …”

The Dose–Response Decrease in Heart Rate Variability: Any Association with the Metabolites of Polycyclic Aromatic Hydrocarbons in Coke Oven Workers? by Xiaohai Li (136211)

“…After adjustment for potential confounders, elevation per interquartile range (IQR) (1.81 µg/mmol creatinine) of urinary 2-hydroxynaphthalene was associated with a 5.46% (95% CI, 2.50–8.32) decrease in standard deviation of NN intervals (SDNN). …”

DAF-16/FOXO is Required for Locomotory Healthspan and Lifespan Benefits of Genetic Glycolysis Disruption. by Brian Onken (86790)

“…<i>daf-16</i> mutants are documented to have lowered locomotory ability vs. WT later in life [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref091" target="_blank">91</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref092" target="_blank">92</a>]; we note that, although comparison of scores across experiments is not possible due to variation in baseline values, the swimming rate of <i>daf-16(mgDf50)</i> control animals was slightly lower than WT controls on the same day of life (in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.g001" target="_blank">Fig 1C</a>; mean of 46.17 head thrashes/30 sec. for <i>daf-16</i> vs. 52.17 head thrashes/30 sec. for WT on day 10). …”