DataSheet3_Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway.ZIP by Qianqian Huang (1409008)

“…By mapping the significantly regulated proteins, we identified five hub proteins: PPP2CA, Gsk3β, PP3CC, PRKACA, and BCL-2 that were associated with dopaminergic synapse and apoptosis signaling pathway, respectively. …”

Datasets and metadata supporting the published article: BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression by Hanan S. Elsarraj (8473172)

“…</div><div> </div><div><b><br></b></div><div><b>Study aims and methodology: </b></div><div>The aim of the related study was to determine the molecular processes underlying progression to invasion in DCIS using PDX DCIS MIND animal models. Using a novel intraductal model they identify downregulation of specific STAT3 targets to promote progression and use a purified component from rosemary extract to show that treatment <i>in vivo</i> decreases DCIS progression in patient derived DCIS and cell line models.…”

Table_1_Pharmacokinetic and Pharmacogenetic Factors Contributing to Platelet Function Recovery After Single Dose of Ticagrelor in Healthy Subjects.DOCX by Qian Zhu (191342)

“…Effects of CYP2C19^*2, CYP2C19^*3, CYP3A5^*3, UGT1A1^*6, UGT1A1^*28, UGT2B7^*2, UGT2B7^*3, SLCO1B1 388A>G, and SLCO1B1 521T>C, on the pharmacokinetics of ticagrelor and M8, and platelet function recovery were investigated.…”

Data_Sheet_1_Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout.docx by Eldiza Puji Rahmi (8584506)

“…The anti-hyperuricemic activity was initially assessed by XO inhibition with a spectrophotometric in vitro assay. The most active extract was further investigated on hyperuricemic rat model induced by potassium oxonate to determine serum uric acid levels and liver XO effect. …”

DataSheet1_Numerical evaluation of methanol synthesis in catalytic wall-coated microreactors: scale-up and performance analysis of planar and monolithic designs.docx by João Lameu da Silva (19305355)

“…In particular, the MRP showed a potential feature for scale-up due to the decreased pressure drop. …”

Table1_Changes in postoperative opioid prescribing across three diverse healthcare systems, 2010–2020.pdf by Jean Coquet (12867691)

“…Over the study period, MME decreased significantly at VHA (37.5–30.1; p = 0.002) and Medicaid (41.6–31.3; p = 0.019), and increased at AMC (36.9–41.7; p < 0.001). …”

Temporal Gene Expression Profiling during Rat Femoral Marrow Ablation-Induced Intramembranous Bone Regeneration by Joel K. Wise (240576)

“…<div><p>Enhanced understanding of differential gene expression and biological pathways associated with distinct phases of intramembranous bone regeneration following femoral marrow ablation surgery will improve future advancements regarding osseointegration of joint replacement implants, biomaterials design, and bone tissue engineering. A rat femoral marrow ablation model was performed and genome-wide microarray data were obtained from samples at 1, 3, 5, 7, 10, 14, 28, and 56 days post-ablation, with intact bones serving as controls at Day 0. …”

Supercoil DNA relaxation assay and ROS quantification assays by flow-cytometry. by Ana K. Ibarrola-Vannucci (10573898)

“…Lanes 5–7: DNA plus 50 μM FeCl₃, 10 mM H₂O_2, and decreasing PHB2 concentrations of 500, 250 and 125 μg/mL, respectively. …”

Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction, Manning et al raw data by Gianna Manning (19858309)

“…Nuclear stiffness increases upon loss of H3K9me2 and decreases upon loss of H3K9me3.</b></p><p dir="ltr"><b>Figure 5. …”

Palmitate-induced loss of caveolin-3 from the T-tubule system in the heart. by Catherine J. Knowles (400844)

“…<p><b>A</b>) Localization of caveolin-1 and -3 in confocal images of isolated cardiomyocytes from mice fed standard, MCT or palmitate diet for 12 weeks. …”

Alternative splicing events affecting PTPRC exons 4 to 7. by Charlotte Vandermeulen (11457794)

“…(B) Increased inclusion of exon 4. Decreased inclusion of exon 5 (C), 6 (D) and 7 (E). …”

Video_7_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”

Application of Ion Torrent Sequencing to the Assessment of the Effect of Alkali Ballast Water Treatment on Microbial Community Diversity by Masanori Fujimoto (629927)

“…<div><p>The impact of NaOH as a ballast water treatment (BWT) on microbial community diversity was assessed using the 16S rRNA gene based Ion Torrent sequencing with its new 400 base chemistry. …”

Video_3_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”

Video_1_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”

Supplementary Figures from Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors by Damir Varešlija (7954046)

“…Images were captured from UCSC Genome Browser. V, vehicle; E, estrogen; A, androstenedione. Figure S9. …”

Video_10_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”

Widespread cDNA synthesis artifact in long reads. by Amoldeep S. Kainth (17291225)

“…<p><b>A.</b> Plot showing enrichment of primer 1 at the 5’ end and the reverse complement of primer 1 at the 3’ end of artifactual reads. …”

Video_2_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”

Video_9_In silico Description of LAT1 Transport Mechanism at an Atomistic Level.MPG by Luca Palazzolo (5681993)

“…<p>The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine (DIT), a well-known LAT1 inhibitor. …”