The Type 2 Diabetes Risk Allele of <i>TMEM154</i>-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes by Marie Neergaard Harder (232759)

“…Significant associations between <i>TMEM154</i>-rs6813195 and the beta cell measures insulinogenic index and disposition index and between <i>FAF1</i>-rs17106184 and 2-hour serum insulin levels were selected for further investigation in additional Danish studies and results were combined in meta-analyses including up to 6,486 Danes.</p><p>Results</p><p>We confirmed associations with type 2 diabetes for five of the seven SNPs (<i>TMEM154</i>-rs6813195, <i>FAF1</i>-rs17106184, <i>POU5F1/TCF19</i>-rs3130501, <i>ARL15</i>-rs702634 and <i>ABCB9/MPHOSPH9</i>-rs4275659). …”

S1/2^-/- mice display novelty induced hyperactivity, decreased anxiety and exploratory behavior and working memory disturbances. by Paul C. Baier (650225)

“…WT: n = 24, S1/2^-/-: n = 26. A) Novelty-induced hyperactivity in S1/2^-/- mice as assessed by moving distance in the open field (p_MW = 0.0006). …”

Loss of primary cilia and decreased nephron number in mice with Tamoxifen-induced <i>Kif3a</i> deficiency. by Lijun Chi (196000)

“…(D, E) The number of primary cilia (green) is markedly decreased in both SIX2-positive cells (nephrogenic precursors) and in ureteric cells <i>Kif3a™</i> kidney (E, asterisk) compared to WT kidney (D). …”

DataSheet2_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.pdf by Sunil Veeravalli (5074115)

“…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …”

DataSheet1_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.PDF by Sunil Veeravalli (5074115)

“…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …”

HDAC5 inhibitors reverse the decreased expression of GR induced by DEX in cultured prefrontal cortical astrocytes. by Shi-Ying Yuan (2937669)

WT1 mRNA and WT1 lncRNA are co-expressed from the same locus. by Gregory McCarty (708081)

Subjects:

Mutant channel with deletion of the S10 region has decreased surface expression in a stable HEK293 cell line. by Shumin Bian (191969)

“…Surface to total ratios were obtained by integration of the histograms. There is a 40% decrease in surface protein expression for the HSloΔS10 mutant determined by the surface to total HSlo ratio (+/− SEM, p = 0.032 in two sample t-test .n = 5).…”

Data_Sheet_2_Mycovirus Fusarium oxysporum f. sp. dianthi Virus 1 Decreases the Colonizing Efficiency of Its Fungal Host.pdf by Almudena Torres-Trenas (6445943)

Data_Sheet_1_Mycovirus Fusarium oxysporum f. sp. dianthi Virus 1 Decreases the Colonizing Efficiency of Its Fungal Host.docx by Almudena Torres-Trenas (6445943)

MCU is required for normal presynaptic Ca²⁺ clearance and MCU expression is decreased in LKB1-null hippocampi. by Seok-Kyu Kwon (3151941)

MAF1 protein expression is significantly decreased in luminal, HER2-positive, and TNBC breast cancer subtypes. by Stephanie Cabarcas-Petroski (9631636)

Exposure to LPS decreases insulin, PDX-1 and MafA gene expression in isolated islets via TLR4. by Julie Amyot (167960)

Decreased recruitment of NK, CD4+ and CD8+ T cells in HSV-2 infected Fas and FasL-deficient mice. by Malgorzata Krzyzowska (587002)

Effect of <i>slc43a3</i> deletion on physical activity of male and female WT and KO mice. by Aaron L. Sayler (19797446)

The pathogenicity of <i>Radopholus similis</i> to tomato plants is decreased significantly after soaking with <i>Rs-crt</i> dsRNA. by Yu Li (183836)

The Transition from a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk by Heba M Ismail (9568748)

“…Conclusions</p> <p>A transition from an increase to a decrease in AUC C-peptide approximately 1.5 years pre-diagnosis was validated in two independent cohorts. …”

PLB is a target gene of miRNA 221. by Hongyu Li (1332669)

<i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus. by David F. Wozniak (78177)

“…During testing, the two groups in cohort 2 were 5.0 months old and had the same sample sizes and sex distribution (n = 10: M = 4; F = 6).…”

The deletion of <i>gdpP</i> in <i>S. pyogenes</i> decreases the sensitivity to a β-lactam antibiotic, ampicillin. by Kyu Hong Cho (322773)