NTD125 stabilizes WT p53 <i>in vitro</i>. by Anuj Kumar Sharma (219374)

“…Recombinant p53 was heated and conformational changes monitored with PAb1620 and PAb240 by IPP at (37–45°C); gradual loss of wild type conformation was observed (Panel-1, lanes 2,5,8,11,14 & 16), mutant conformation was stable at (RT-42°C) (Panel-1, lanes 3, 6, 9, 12) and decreased at 45°C (Panel-1, lane 15). …”

Decreased trabecular bone volume and increased osteoclasts in IKK2SSEE^MYELO -tg mice. by Jesse E. Otero (320123)

Three-, bi- and mono-functional Vγ9Vδ2 T-cell subsets decrease in HIV+ patients. by Rita Casetti (608635)

Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia by Jingping Ge (636557)

“…We also observed the up-regulation of <i>TGFβ1R</i>, <i>TGFβ2</i>, <i>CDKN1A</i> and <i>SERPINE1</i> mRNA, and the significant decrease of <i>GATA1</i> mRNA in the primitive multilineage progenitors. …”

Increase of proliferating progenitor cells and decrease of terminally differentiated granule neurons in the immature dentate gyrus of <i>PC3/Tis21</i>-null mice at P14. by Stefano Farioli-Vecchioli (256006)

“…(<b>B</b>, <b>C</b>) The same significant increase is observed for the number of dividing progenitor cells, identified either as (<b>B</b>) Ki67-positive, or as (<b>C</b>) Ki67/Sox2-positive cells (1.5-fold). (<b>D</b>) The newly generated neurons (1 hour pulse of BrdU) decreased sharply (20%). …”

Mice with a Mutation in the <i>Mdm2</i> Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis by Takuya Kamio (2589673)

“…Competitive BM repopulation experiments showed that donor BM harboring the <i>Mdm2</i>^<i>C305F</i> mutation possessed decreased repopulation capacity compared to WT BM, suggesting a functional stem cell deficit. …”

By Regulating Mitochondrial Ca²⁺-Uptake UCP2 Modulates Intracellular Ca²⁺ - Fig 4 by Lukas Jaroslaw Motloch (2139028)

“…<p>a-c) Ca²⁺ transients in UCP2^-/- cardiomyocytes (UCP2) ± 10 and 100 nM Ru360. a) Representative traces of (Ca²⁺)c (left) and (Ca²⁺)m (right), and b-c) Statistical analysis: 10 nM Ru360 (10Ru) had no impact on either (Ca²⁺)c or (Ca²⁺)m transient amplitudes of UCP2^-/- cardiomyocytes. 100 nM Ru360 (100Ru) significantly decreased the amplitude in both compartments without affecting the rate of rise. …”

Flow cytometric evaluation of the γδ T cell receptor (TCR) repertoire in control vs. early and late stage tumor-bearing mice (distribution on left panels, x ± SD, right panels, * =... by Benjamin H. Beck (453940)

“…Additionally, there were no changes in the proportions of Vδ1, Vδ4, and Vδ6.3 at day 10. A significant decrease of the %Vδ6.3 population at end stage was offset by a parallel increase in %Vδ4 cells. …”

By Regulating Mitochondrial Ca²⁺-Uptake UCP2 Modulates Intracellular Ca²⁺ - Fig 1 by Lukas Jaroslaw Motloch (2139028)

“…Basic mCa1 in WT showed three amplitude levels with -1.16±0.02 pA being the most common observed amplitude [I_unitary: -1.16±0.02 pA, n = 30; μ₁: -1.16 pA (65%), μ₂: -1.71 pA (31%), μ₃: -3.10 pA (4%)]. c) In cardiac mitoplasts from WT Ru360 (200 nM) in PS (n = 8) and Ru360 (10μM) in BS (n = 5) as well as ATP (1mM) in BS (n = 5) decreased total open probability (Po,total) of mCa1 (*p<0.05). d) Examples of consecutive original traces of cardiac mCa1 in mitoplasts from WT: mCa1 in WT vs. mCa1 in WT + Ru360 (200 nM) in pipette solution (PS) vs. mCa1 in WT + Ru360 (10 μM) in bath solution (BS) vs. mCa1 in WT + ATP (1mM) in BS. e) Slope conductance of mCa1 in WT (12.59±1.57 pS, n = 17) and of mCa1 in UCP2^-/- (12.79±1.83 pS, n = 13) was not different.…”

HBV RNA is methylated by NSUN2 in the cell. by Jiangpeng Feng (9287738)

LC–MS/MS analysis of 5-, 8-, 11-, 12- and 15-HETE levels in WT and Tie2-sEH Tr mouse heart perfusates at baseline and post-ischemia. by Ahmad Hanif (3094800)

“…<p>In Tie2-sEH Tr mice, the levels of 5-HETE (A), 8-HETE (B), 11-HETE (C), 12-HETE (D), 15-HETE (E), were decreased compared to WT mice at baseline and post-ischemia (<i>P</i> < 0.05). …”

By Regulating Mitochondrial Ca²⁺-Uptake UCP2 Modulates Intracellular Ca²⁺ - Fig 3 by Lukas Jaroslaw Motloch (2139028)

“…WT). g) I_NCX WT vs. UCP2^-/- cardiomyocytes: forward I_NCX was elicited by 1 s of exposure to 5 mM caffeine using a holding potential of -40 mV. …”

Expression of WT dyskerin can rescue the expression of <i>LGR5</i>, <i>WLS</i> and <i>FRZB</i>. by Bai-Wei Gu (740949)

Automated wound healing assay showing decreased motility of IL-4 treated HCAEC. by Tom Skaria (2733439)

Data_Sheet_1_Membrane-Located Expression of Thioesterase From Acinetobacter baylyi Enhances Free Fatty Acid Production With Decreased Toxicity in Synechocystis sp. PCC6803.docx by Shajia Afrin (6010424)

“…Moreover, the mAcT strain generated around 1.5 and 1.9 times less reactive oxygen species than AcT and WT, respectively. …”

HC-070 decreases anxiety in a standard EPM. by Stefan Just (4811358)

ΔNp73α mRNA levels are high in the skin of HPV38 E6/E7 Tg mice, but are decreased in the UV-induced skin lesions harbouring p53 mutations. by Daniele Viarisio (348197)

DJ-1 knockdown in BV-2 microglia cells enhances LPS-induced death of co-cultured SH-SY5Y neuronal cells. by Chia-Hung Chien (19355)

“…Cell viability of SH-SY5Y was evaluated by using MTT assay (A) and methylene blue assay (B). …”

Decreased branching, partial right isomerization and epithelial proximalization in CKO lungs. by Stijn P. De Langhe (38981)

“…<p>(a–d) β-gal staining of <i>Dermo1^Cre/+/Rosa26R</i> WT lungs at E11.5 and E13.5 reports Cre recombination activity in the mesenchyme of the embryonic lung. …”

HSP90 inhibition by 17AAG induces pigmentation in human melanoma cells. by Sandeep S. Joshi (4888618)