A New Rotane Family:  Synthesis, Structure, Conformation, and Dynamics of [3.4]-, [4.4]-, [5.4]-, and [6.4]Rotane¹ by Lutz Fitjer (2466634)

“…All syntheses are based on bicyclobutylidene (<b>9</b>):  [2+1] cycloaddition of cyclobutylidene yields [3.4]rotane (<b>5</b>) (<b>9</b>−<b>5</b>), [2+2] cycloaddition of trimethyleneketene followed by spiroalkylation of the resulting trispiroketone <b>10</b> yields [4.4]rotane (<b>6</b>) (<b>9</b>−<b>10</b>−<b>13</b>−<b>14</b>−<b>6</b>), homologization of <b>10</b> via β-hydroxy selenides gives access to tetraspiroketone <b>11</b> and pentaspiroketone <b>12</b> (<b>10</b>−<b>15</b>−<b>11</b>−<b>16</b>−<b>12</b>), and further elaboration directed toward a cyclopropylcarbene−cyclobutene rearrangement yields [5.4]rotane (<b>7</b>) and [6.4]rotane (<b>8</b>) [<b>11</b>(<b>12</b>)−<b>18</b>(<b>24</b>)−<b>19</b>(<b>25</b>)−<b>20</b>(<b>26</b>)−<b>21</b>(<b>27</b>)−<b>22</b>(<b>28</b>)−<b>23</b>(<b>29</b>)−<b>7</b>(<b>8</b>)]. …”

Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression. by Christopher F. Bennett (3875731)

“…<p><b>(A)</b> Intestinal fat staining decreases from RNAi knockdown of <i>tald-1</i> or <i>cco-1</i>. …”

General procedure for the synthesis of A and A-c1. by Xueqin lu (22250795)

The Hh signaling pathway effectors are decreased in E14.5 <i>Fuz^−/−</i> mouse embryos. by Zichao Zhang (344301)

“…<p><b>A</b>) Immunofluorescence of Patched1 in sagittal sections of E14.5 <i>Fuz^+/−</i> heterozygous embryos. …”

Fibγ^Δ5 mice display decreased survival following <i>S. aureus</i> peritonitis. by Oscar Negrón (11965511)

A mutation in <i>dSK</i> results in decreased long-term memory 24 h after 5 h ‘extended’ training session. by Ahmad N. Abou Tayoun (326696)

MeV induced <i>APOBEC3A</i> upregulation. by Pierre Khalfi (7868252)

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Decreasing <i>EloC</i> expression suppresses ectopic veins induced by <i>blistered</i> loss-of-function. by Julien Rougeot (131135)

Increased apoptosis and decreased necrosis after BCL-W and BCL2 and autophagy inhibition. by Anatasha C. Crawford (255140)

Decreased abundance of CD11c+ cells in the BAL of naïve IL-19-/- 129xBL6 mice. by Carol Hoffman (196241)

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity-5 by Rodrigo A Fuentealba (77901)

“…</p><p></p>d triangle), 10 μg (open triangle) or 20 μg (open inverted triangle) of an ApoER2 coding plasmid were incubated with 1 nM I-labeled-anti-HA IgG or 5 nM I-labeled-diFeTf for 1 h at 4°C and then shifted to 37°C for the indicated times. …”

Poly (I:C) decreases HIV-1 transcription in cervical tissues by enhancing IRF7 mediated antiviral responses and reducing RelA expression. by Christiane Rollenhage (762318)

Experimental Setup. by Mengnan Wu (769253)

Conditional mu-cKO mice show decreased opiate-induced analgesia in the CFA-induced inflammatory pain model. by Raphaël Weibel (458030)

“…Mu-cKO mice displayed a decreased analgesic response in the mechanical sensitivity test for the 0.03 mg/kg fentanyl dose. n=5-10/genotype. …”

Variants enriched in an <i>Ae</i>. <i>aegypti</i> cell line <i>(</i>Aag2) have increased fitness in Aag2 cells but decreased fitness in a human cell line (MRC-5). by Chelsea Cereghino (15188341)

Suppression of calpain activity by calpain inhibitors or c siRNA-calpain-II decreased honokiol-induced cell apoptosis. by Meei Ling Sheu (80695)

Quantification of TNF-α- (A), IL-1β- (B), iNOS- (C) and TGF-β RII - (D) positive cells in cheek pouch tissues of hamsters subjected to 5-FU-induced oral mucositis, on day 14. by Maria Adriana Skeff (670466)

Febrile urinary tract infection in a 20-month-old boy (patient no. by Han Byeol Lee (5519246)

Continuum of hepatitis C care in France: A 20-year cohort study by Coralie Hermetet (4397638)

“…Antiviral treatment was initiated for 179 (42.9%) of the 379 (90.9%) patients attending specialist consultations. CoC was associated with screening after 1997 (HR 2.0, 95%CI 1.4–2.9), age > 45 years (HR 1.5, 95%CI 1.02–2.3), patient acceptance of care (HR 9.3, 95%CI 5.4–16.10), specialist motivation for treatment (HR 10.9, 95%CI 7.4–16.0), and absence of cancer (HR 6.7, 95%CI 1.6–27.9). …”

Decreased expression levels of SPI-1 genes in <i>bipA</i>-deleted strain at 20°C. by Eunsil Choi (8271039)

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