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UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes.
Published 2013“…The histogram indicates the distribution of genes by average fold-change upon <i>unc-62</i> RNAi. For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”
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Osr1 heterozygous mice experienced decreased bile acid synthesis in the liver.
Published 2022“…<p>(A). Osr1 male mice had a decreased trend of hepatic bile acid compared to WT mice. …”
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WT1 siRNA decreases proliferation, pAKT, and Bcl2 expression.
Published 2024“…<b>C.</b> RT-qPCR of WT1, p<0.05(*), vFLIP(ns), LANA, p<0.0001(****), K8.1, p<0.0001(****), and BCL2 p<0.05(*) in the setting of WT1 knockdown in ISLK BAC-16 with WT1 siRNA in comparison to a control siRNA using two-sided, unpaired student’s t-tests. …”
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Nasal mucociliary clearance was decreased in <i>Ttll1</i><sup>−/−</sup> mice.
Published 2015“…In the <i>Ttll1</i><sup>−/−</sup> mice, a larger amount of Evans blue persisted in the nasal cavity and a lesser amount was swallowed compared with that in the wild-type (WT) mice (mean ± SEM, n = 5, *P < 0.005 by two-tailed Student's t test).…”
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Cellular stress decreases TDP-43 levels in patient neurons with the TDP-43 A90V mutation.
Published 2013Subjects: -
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Spatial training decreases the association between Ndfip1 and Nedd4 and decreases endogenous Beclin 1 ubiquitination in the hippocampus.
Published 2023“…Endogenous Beclin 1 ubiquitination level is decreased in Nedd4 siRNA-transfected rats (t<sub>1,6</sub> = 5.78, <i>p</i> = 0.001). …”