Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …"
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming حسب Mohamed, Assem T.

"…On the other hand, at the same time-on-stream LaNiMgO-Rh lost 0.3 and 0.7 % of its maximum CO2 and CH4 conversions, respectively.In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO2 conversion from 77.6 % to 70.5%, the CH4 conversion decreased from 72.3% to 64.2%. …"
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Evidence of two mechanisms involved in Bacillus thuringiensis israelensis decreased toxicity against mosquito larvae: Genome dynamic and toxins stability حسب Elleuch, Jihen

"…This bacterium is characterized by a dynamic genome able to win or lose genetic materials which leads to a decrease in its effectiveness. …"
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Investigation of solar PV performance under Doha weather using a customized measurement and monitoring system حسب Touati, Farid

"…Results predict that the maximum power output from a Poly-crystalline panel decreases by around 30% for a dust exposure of five months. …"
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Effect of octylphenol polyethylene oxide on the corrosion inhibition of steel in 0.5 M H2SO4 حسب Algaber, A.S

"…The experimental data were fitted with the Flory-Huggins isotherm at a molecular ratio of 5:1. The Gibbs energy of adsorption decreases with the temperature. …"
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country حسب Zaghloul, Nancy

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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…"
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Nutritional quality and health risk of pepper fruit as affected by magnesium fertilization. حسب Lu, Ming

"…As a result, Mg fertilization decreased the comprehensive nutrition level of pepper by 16.6%. …"
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Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections حسب Qassim, Suelen H.

"…Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy the inverse of infectiousness, we investigated infectiousness of SARS-CoV-2 infections by variant, age, sex, vaccination status, prior infection status, and reason for testing in a random sample of 18,355 RT-qPCR-genotyped infections. …"
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Pollution Characteristics of Particulate Matter (PM2.5 and PM10) and Constituent Carbonaceous Aerosols in a South Asian Future Megacity حسب Aslam, Afifa

"…Results of the study revealed that the mass concentration of PM2.5 and PM10 is at an elevated level throughout Faisalabad, with ambient PM2.5 and PM10 points that constantly exceeded the 24-h standards of US-EPA, and National Environment Quality Standards (NEQS) which poses harmful effects on the quality of air and health. …"
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L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats . حسب Djouhri, Laiche

"…Consistent with this hypothesis, we found (7 days post-SNA), in SNA rats with established pain hypersensitivity, slower AP kinetics in axotomized L5-neurons and faster AP kinetics in L4-nociceptive neurons including decreased rise time in Aδ-and Aβ-fiber nociceptors, and after-hyperpolarization duration in Aβ-fiber nociceptors. …"
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An Improved Fault Tolerant Five-Phase Induction Machine Using A Combined Star/Pentagon Single Layer Stator Winding Connection حسب Abdel-Khalik, Ayman S.

"…For the healthy case, the machine is similar to a conventional star connected five-phase machine. …"
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An Eco-Friendly Quaternary Ammonium Salt as a Corrosion Inhibitor for Carbon Steel in 5 M HCl Solution: Theoretical and Experimental Investigation حسب Jalab, Rem

"…This study aims to investigate the performance of an environment-friendly Quaternium-22 (Q-22) surfactant which is widely used in cosmetics for C-steel corrosion inhibition in a 5 M HCl medium. Weight loss experiments were performed at different concentrations and immersion times, presenting a maximum efficiency at 2.22 mmol·L−1. …"
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Effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon حسب Samaha, Ali A.

"…Objective: This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive for this virus in Lebanon. …"
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The impact of COVID-19 pandemic lockdown on smoking habits and lifestyle: A cross-sectional study حسب Khamees, Almu'atasim

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Evidence by ac-conductivity for the higher mobility of boron (over aluminium)-associated Brønsted sites in boron-modified HZSM-5 حسب Sayed, Moein B.

"…A correlation ac-conductivity analysis is performed at 102–105 Hz, 373–613 K and 0.8 V for characterizing the effect of increasing boron incorporation in HZSM-5 lattice on altered electric features in BZSM-5 samples of similar origin. …"
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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim, Al-Fahdawi

"…The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). …"
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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim, Al-Fahdawi

"…The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). …"
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