A Point Mutation in a lincRNA Upstream of <i>GDNF</i> Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies by Jocelyn Plassais (564630)

“…Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor abilities and spinal reflexes remain intact. Through a Genome Wide Association Study (GWAS) with 24 affected and 30 unaffected sporting dogs using the Canine HD 170K SNP array (Illumina), we identified a 1.8 Mb homozygous locus on canine chromosome 4 (adj. p-val = 2.5x10^-6). …”

Diabetic HDL decreases cell adhesion to ECM. A) by Bing Pan (122540)

Simulation of parasite motion with a decreased flagellum stiffness of . by Florian A. Overberg (21402904)

Detection of epistasis is rescued by simultaneous analysis of multiple independently-evolved populations. by Gabriele Pedruzzi (5753792)

PIMT decreased the formation of amyloid-like fibrils of H79A alanine substituent of αA66–80 peptides. by Kosuke Magami (10654473)

Recovery of decreased Hb level after DCV/ASV treatment Mean values and SDs of the Hb levels at each time point are indicated. by Nobuyuki Matsumoto (239090)

Subjects:

Variation of the time window of detection with recombination. by Gabriele Pedruzzi (5753792)

DAS and Y27632 down-regulated the mRNA and protein expression of CK8-RhoA/ROCK1 pathway and up-regulated TJs expression in intestines of infected mice. by Wen Wen Zheng (17721404)

Advancing the science of NOWS research. by Sarah E. Maylott (14560785)

“…Approximately 50% of these newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS) within 5 days of birth. It is not known which infants will develop NOWS, therefore, the current hospital standard-of-care dictates a 96-hour observational hold. …”

Protocol measures. by Sarah E. Maylott (14560785)

“…Approximately 50% of these newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS) within 5 days of birth. It is not known which infants will develop NOWS, therefore, the current hospital standard-of-care dictates a 96-hour observational hold. …”

Cry variables. by Sarah E. Maylott (14560785)

“…Approximately 50% of these newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS) within 5 days of birth. It is not known which infants will develop NOWS, therefore, the current hospital standard-of-care dictates a 96-hour observational hold. …”

Critical Membrane Concentration and Mass-Balance Model to Identify Baseline Cytotoxicity of Hydrophobic and Ionizable Organic Chemicals in Mammalian Cell Lines by Jungeun Lee (142511)

“…However, their applicability is limited to hydrophilic neutral compounds. To develop a prediction model that includes more hydrophobic and charged organic chemicals, a mass balance model was applied for mammalian cells (AREc32, AhR-CALUX, PPARγ-BLA, and SH-SY5Y) considering different bioassay conditions. …”

Impact of individual GLP-1 receptor agonists on hypoglycemia, treatment discontinuation, HbA1c <7.0%, HbA1c <6.5% of direct pairwise meta-analysis. by Zhixia Li (2736331)

The number of FOXM1-positive cells decreases as pituitary development progresses. by Michael J. Calderon (755132)

A partially porous sheath with a moderate length <i>L</i>_<i>p</i> limits the decrease of VEGF concentration while still increasing cell density and oxygen concentration... by Rachel Coy (4027016)

S5 Fig - by Ty A. Bottorff (14035065)

Dosing analysis of the YFV vaccine (subcutaneous route) in interferon-1 receptor knockout mice (A129). by Ana C. Vicente Santos (11649118)

S5 Fig - by Xinyue Yang (629144)

Aurora A is less likely to be responsible for ULK1 band shift in mitosis. by Zhiyuan Li (205620)

S1 Data - by Saori Miyagishima (14593506)

Subjects: