PI3Ks regulate plaque morphology and early protein production. by Shannon McNulty (248670)

“…</b> PI3K inhibitors do not decrease early viral protein expression. BSC40 cells were infected at pH 7.4 and MOI = 5 with VV and PI3K inhibitors were added 1 hour post-viral entry and allowed to infect for an additional 2 hours. …”

RNAi knockdown of pex3 reduces peroxisome numbers and impairs viability. by Joseph E. Faust (580247)

“…Weak knockdown (<i>arm</i>><i>pex3.IR</i>) did not appreciably decrease viability (95.3±1.0%; n = 190). At 18°C, viability of <i>Da^G32</i>><i>pex3.IR</i> flies was reduced to 25.2±1.5% (n = 330). …”

RNAi knockdown of pex3 reduces peroxisome numbers and impairs viability. by Joseph E. Faust (580247)

“…Weak knockdown (<i>arm</i>><i>pex3.IR</i>) did not appreciably decrease viability (95.3±1.0%; n = 190). At 18°C, viability of <i>Da^G32</i>><i>pex3.IR</i> flies was reduced to 25.2±1.5% (n = 330). …”

Upstream bubble collapse and transition into elongation are delayed in the P266L mutant. by Guo-Qing Tang (540328)

“…(C) The fraction of EC versus time was fit to a single exponential function. The error bars in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091859#pone-0091859-g005" target="_blank">Fig 5C</a> is the standard error from fitting smFRET histogram to a single exponential function. …”

The GePPI screening strategy to identify proteins involved in the inactivation of SBF via phosphorylation by Clb/Cdc28. by Emily N. Manderson (272555)

“…In this example, deletion of protein A results in a decrease in the PCA signal, whereas deletion of protein D results in an increase in signal. …”

Analyses of the intracellular Ca²⁺ mobilization in Vero cells incubated with EVs of <i>T</i>. <i>cruzi</i>. by Lissette Retana Moreira (5325326)

“…Also, when the cells were incubated with 2.5 μM EDTA, a calcium chelator, there was a 1.69 ± 0.01 increase in the fluorescence levels at 10 min of incubation, when the fluorescence intensity started to decrease and it was possible to observe a more granulated pattern of fluorescence in the cytoplasm (black line). …”

Light scattering and electron micrographs of mitochondria exposed to transient calcium insult. by Saori Morota (428715)

“…Experiments were performed with 1 µM cyclosporin A (CsA, n = 2) or its vehicle ethanol (EtOH, Control, n = 5). …”

DTAB mimics effects of RA on early development. by Chetana Sachidanandan (44243)

“…Embryos were treated with DTAB (12.5 µM), RA (1 µM), DEAB (10 µM) and DTAB+DEAB or DMSO from 1hpf to 48hpf (for the bright field photography) and to 70% epiboly (for <i>in situ</i> hybridization for <i>ntl</i> and <i>cyp26a1</i>). …”

Table_1_Use of Prazosin for Pediatric Post-Traumatic Stress Disorder With Nightmares and/or Sleep Disorder: Case Series of 18 Patients Prospectively Assessed.docx by Vladimir Ferrafiat (9154643)

“…</p>Results<p>Among the 18 patients (10 girls and 8 boys), 13 (72%) had experienced sexual abuse and 5 (28%) family violence. After 1 month of treatment with a mean prazosin dose of 2.16 ( ± 0.6) mg/day, the CGI-S score significantly decreased from 5.3 ( ± 0.9) to 2.9 ( ± 0.7) (improvement of 43%). …”

Patterns of astrocytic process coverage and vessel sprouting in the control and class II <i>orc3/hGFAP-cre</i> mutant cortices during early postnatal development. by Shang Ma (125139)

“…<p>(<b>A–C</b>) Astrocytic process coverage in the upper third of control cortices at P3 (<b>A</b>), P5 (<b>B</b>), and P7 (<b>C</b>). …”

Clinical experience with titrating doses of digoxin antibodies in acute digoxin poisoning. (ATOM-6) by Betty S. Chan (6386723)

“…Initial median digoxin and potassium concentrations were 14.5 nmol/L (IQR: 10.9–20) [11.2 µg/L(IQR: 8.4–15.4)] and 5 mmol/L (IQR: 4.5–5.4 mmol/L), respectively. …”

Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus by Yan Jin (143500)

“…We found that NaSal hyperpolarized the resting membrane potential, decreased the input resistance, and suppressed spontaneous and current-evoked firing in GABAergic neurons, but not in 5-HTergic neurons. …”

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing by Joshua N. Farr (799622)

“…High-throughput RNA sequencing (RNAseq), on the other hand, offers an unbiased approach to examine the entire transcriptome. Here we present an RNAseq analysis of human bone samples, obtained from iliac crest needle biopsies, to yield the first <i>in vivo</i> interrogation of all genes and pathways that may be altered in bone with aging and E therapy in humans. 58 healthy women were studied, including 19 young women (mean age ± SD, 30.3 ± 5.4 years), 19 old women (73.1 ± 6.6 years), and 20 old women treated with 3 weeks of E therapy (70.5 ± 5.2 years). …”

Table_1_Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.DOCX by Hang Li (123039)

“…</p><p>Methods: The levels of TETs in peripheral blood mononuclear cells (PBMCs), peripheral myeloid DCs (mDCs), and plasmacytoid DCs (pDCs) from house dust mite (HDM)-sensitive AR patients and healthy volunteers (HC) were evaluated by qPCR and flow cytometry. The levels of 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) in PBMCs were determined by DNA-5hmC and DNA-5mC ELISA. …”

The effect of salts, pH and additives in the lysis buffer on the solubility of RGP1. by Ditte Hededam Welner (4099906)

“…Buffers 13 and 19–21, containing 1-2M salt, as well as the low-pH (4.3–5.5) buffers 11,12,15, 22 and 30 decrease the amount of soluble RGP1, while lower salt concentrations as well as several additives increase the amount of soluble RGP1 relative to the standard lysis buffer (std: 50 mM HEPES pH 8.0, 250 mM NaCl, 5 mM MgCl₂). …”

Grid division diagram. by Ming Zhang (9736)

“…When the height is 2.5m and above, the windbreak efficiency is greater than 90%, and the windbreak effect is significantly improved. (2) The change of sand barrier height has a significant effect on the windbreak efficiency between the second and third sand barriers. (3) Among the three sand-blocking fences, when the height of the sand-blocking fence is 2.5m, the thickness of the sand is 50.51% and 58.33% higher than that of the 2m high sand-blocking fence, and the sand-blocking effect is the most significant. …”

Model calculation diagram. by Ming Zhang (9736)

“…When the height is 2.5m and above, the windbreak efficiency is greater than 90%, and the windbreak effect is significantly improved. (2) The change of sand barrier height has a significant effect on the windbreak efficiency between the second and third sand barriers. (3) Among the three sand-blocking fences, when the height of the sand-blocking fence is 2.5m, the thickness of the sand is 50.51% and 58.33% higher than that of the 2m high sand-blocking fence, and the sand-blocking effect is the most significant. …”

Grid independence verification. by Ming Zhang (9736)

“…When the height is 2.5m and above, the windbreak efficiency is greater than 90%, and the windbreak effect is significantly improved. (2) The change of sand barrier height has a significant effect on the windbreak efficiency between the second and third sand barriers. (3) Among the three sand-blocking fences, when the height of the sand-blocking fence is 2.5m, the thickness of the sand is 50.51% and 58.33% higher than that of the 2m high sand-blocking fence, and the sand-blocking effect is the most significant. …”

Figure 8 by Andy M. Reynolds (358209)

“…Mean times do not change significantly when the length scale <i>L</i> is increased or decreased by a factor of 2. …”

Effectiveness of nutritional intervention in overweight women in Primary Health Care by Nathália Luíza Ferreira (12821193)