Image_1_A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors.tif by James J. Harding (12415627)

“…Adult patients with treatment-refractory solid tumors received PF-06671008 (1.5–400 ng/kg) as a weekly intravenous (IV) infusion on a 21-day/3-week cycle. …”

Autonomic nervous system monitoring in intensive care as a prognostic tool. Systematic review by Luis Bento (297825)

A model for calculating mRNA dynamics from an RNA-Seq snapshot. by Jesse M. Gray (527662)

“…<p>(<b>A</b>) The decrease in expression from 5′ to 3′ along an intron, shown as the height of the green “guillotine” blade, is a product of the rate of intron synthesis (<i>S</i>) and the time required to transcribe the intron (<i>T</i>_t). …”

Table_1_Dysregulation of Principal Circulating miRNAs in Non-human Primates Following Ischemic Stroke.XLSX by Jian Chen (15340)

“…For example, mml-miR-191-5p, miR-421, miR-409-5p, and let-7g-5p were found to be significantly overexpressed, whereas mml-miR-128a-5p_R − 2, miR-431_R − 1, and let-7g-3p_1ss22CT were significantly downregulated. …”

Influence of Ocean Acidification on a Natural Winter-to-Summer Plankton Succession: First Insights from a Long-Term Mesocosm Study Draw Attention to Periods of Low Nutrient Concent... by Lennart T. Bach (520701)

“…<div><p>Every year, the oceans absorb about 30% of anthropogenic carbon dioxide (CO₂) leading to a re-equilibration of the marine carbonate system and decreasing seawater pH. …”

Example of host protein coding transcripts significantly upregulated or downregulated in infected samples compared to mock infection. by Seth B. Garren (799962)

Real time PCR in SSc-MVECs of <i>MACF</i>, <i>DIAPH1</i>, <i>DIAPH</i>2, <i>ARPC3</i>, <i>RAC2</i>, <i>CDH5</i>, and <i>ITGB8</i>. by Betti Giusti (74939)

Efficacy and safety of a single radiofrequency ablation of solid benign non-functioning thyroid nodules by Roberto Cesareo (4676131)

A<i>ß</i> stimulation of platelets induces ROS generation and cell membrane scrambling. by Nina S. Gowert (528687)

“…(G) Bar graphs depict mean values ±SEM (n = 5, left panel) of the percentage of human platelets binding Annexin V-Fluos after pre-treatment with caspase inhibitor 1 µM zVAD-FMK (zVAD) followed by a 60 min. exposure with 20 ng/ml A<i>ß</i> in the presence of 2 mM CaCl₂ and in the nominal absence of Ca²⁺ and presence of EGTA, **p<0.01 indicates statistically significant difference to the control in the absence of Aß, *p<0.05 indicates statistically significant difference to results with 20 ng/ml A<i>ß</i> alone in the absence of any pre-treatment. …”

A reconnaissance provenance study of Triassic–Jurassic clastic rocks of the Russian Barents Sea by Andrey K. Khudoley (7352681)

“…The number of Palaeoproterozoic and Archean grains is very small and becomes significant only in a few Jurassic samples. ε_Nd(t) values gradually decrease from −1.5 to +2.5 in Lower Triassic rocks, to −2.0 to −8.2 in Jurassic rocks, suggesting an increasing influence of ancient metamorphic basement erosion in the younger Jurassic rocks. …”

Patterns of avian haemosporidian infections vary with time, but not habitat, in a fragmented Neotropical landscape by Juan Rivero de Aguilar (5917271)

“…We also found a temporal effect, with birds at the end of the five-month study (which ran from the end of the rainy season thru the dry season), being less infected by <i>Plasmodium</i> parasites than individuals sampled at the beginning. …”

Kallikrein 6 as a Serum Prognostic Marker in Patients with Aneurysmal Subarachnoid Hemorrhage by Eduardo Martínez-Morillo (132848)

“…</p> <h3>Conclusions/Significance</h3><p>Decreased serum concentrations of KLK6 are found in patients with aSAH, with the lowest levels in patients who died.…”

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice by Yanna Si (3234477)

“…Cognitive function was assessed 19 days later using a 5-day testing regimen with Morris water maze. …”

Neuronal overexpression of antioxidants reduces sleep, suggesting a role for ROS in sleep regulation. by Vanessa M. Hill (5508401)

“…Each data point represents average sleep in minutes/day measured across 5 days in an individual animal; data are shown as mean ± SEM. …”

Data_sheet_1_Therapeutic effect of psilocybin in addiction: A systematic review.docx by Pim B. van der Meer (9606147)

“…In a pilot study (n = 10), the percentage of heavy drinking days decreased significantly between baseline and weeks 5–12 (mean difference of 26.0, 95% CI = 8.7–43.2, p = 0.008). …”

A global meta-analysis of the effects of plant diversity on biomass partitioning in grasslands by Chao Wang (8847089)

A 10-Year Trend Analysis of Heart Failure in the Less Developed Brazil by Amanda D. F. Fernandes (8618637)

“…Pearson correlation and linear-by-linear association test for trends were calculated, with a level of significance of 5%. Results: From 2008 to 2017, HF admissions decreased 62% (p = 0.004) in Paraiba and 34% (p = 0.004) in Brazil. …”

Inhibition of RhoA by Rhosin blocked phosphorylation of myosin light chain and platelet shape change. by Huzoor Akbar (340517)

“…Data in the bar graphs are mean ± SE from three experiments (*p<0.001). <b>(C-D)</b> Aspirin (1 mM) treated washed human platelets containing apyrase (3 U/ml) were incubated with U46619 (0.01 μM) or thrombin (0.005 U/ml) and platelet shape change was recorded as a decrease in light transmittance using a Lumi-Aggregometer. …”

Supplementary Material for: Stair-Case/Honeycomb Maculopathy in Alport Syndrome: A Case Report by figshare admin karger (2628495)

“…Introduction: Alport syndrome is an inherited disease caused by mutations in COL4A5, COLA3, or COL4A4 resulting in kidney failure, hearing loss and ocular symptoms. …”

There is a non-linear relationship between <i>FOXO</i> expression and nutritional plasticity. by Hui Yuan Tang (196925)

“…Circles indicate flies in which we have manipulated <i>FOXO</i> expression using UAS-GAL4, diamonds indicate wild-type flies reared at different temperatures (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002373#pgen.1002373.s005" target="_blank">Figure S5</a>). …”