Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response by Sebastian Stahl (443212)

“…By affinity purification, we identified the viral M50 protein as an IRE1-interacting protein. M50 expression in transfected or MCMV-infected cells induced a substantial downregulation of IRE1 protein levels. …”

DataSheet_1_New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes.pdf by Hannah Maude (7426886)

“…Two additional results were consistent with a potential role of T2D-eQTL in regulating the 50 identified cis-NEMGs in the context of T2D risk: (1) the 50 cis-NEMGs showed greater differential expression compared to other NEMGs and (2) other NEMGs showed a trend towards significantly decreased expression if their expression levels correlated more highly with the subset of 50 cis-NEMGs. …”

Table_1_Co-exposure of potentially toxic elements in wheat grains reveals a probabilistic health risk in Southwestern Guizhou, China.docx by Dashuan Li (13211184)

“…The mean threshold CR (TCR) values were decreased in the order of children (1.32E-02) > adult females (6.61E-03) > adult males (5.81E-03), respectively, all at unacceptable risk levels. …”

Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors by Ghada M. A. Ajabnoor (3909811)

“…</p><p>Methods</p><p>Healthy young volunteers (5 females, 18 males; mean age +SEM = 23.2 +1.2 years) were evaluated before Ramadan and two weeks into it. …”

Glucose-dependent insulinotropic peptide in the high normal range is associated with increased carotid intima-media thickness by Amra Jujić (524347)

“…<p><b>Research design and methods: </b>Participants at re-examination within the Malmö Diet and Cancer cardiovascular cohort study (n=3734, mean age 72.5 years; 59.3% women; 10.8% subjects with diabetes; fasting GIP available for 3342 subjects; fasting GLP-1 available for 3299 subjects) underwent oral glucose tolerance testing and carotid ultrasound. …”

How common ravens (Corvus corax) exploit anthropogenic food sources through time and space in a semi-transformed, alpine environment by Varalika Jain (10659668)

“…., apparent reliance on and access to resources), specifically (3a) the number of AFSs visited and (3b) the probability of being at AFSs at any given point in time. Movement patterns can reveal information on the foraging decisions made by individuals, including how they use different AFSs. …”

M-SSA Spectra of Internal Variability. by Andrew Westgate (22386403)

“…<p>M-SSA spectra of internal variability — that is, variances of M-SSA modes ranked in the order of decreasing variance — from <b>(a, b)</b> 20CRv3 and <b>(c, d)</b> ERA-20C reanalysis (blue) and <b>(a, c)</b> CMIP5 and <b>(b, d)</b> nonoutlier CMIP6 simulations (red). …”

The combination of three wound healing agents improved urethane-damaged wound healing environment. by Linxin Liu (829738)

“…(B) Three wound healing agents improved urethane-damaged wound healing environment (n = 5). (C) Macrophage depletion reversed improved wound healing environment by three compounds alone but had a slight effect on combination efficacy (n = 5). …”

Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice by Yali Zhang (206227)

“…Using this mouse, we demonstrate that attenuation of GSK3β expression is associated with an increase in parasympathetic responsiveness measured as an increase in the heart rate response to atropine from 17.3 ± 3.5% (n = 8) prior to 41.2 ± 5.4% (n = 8, <i>P</i> = 0.017), an increase in the duration of carbamylcholine mediated bradycardia from 8.43 ± 1.60 min (n = 7) to 12.71 ± 2.26 min (n = 7, <i>P</i> = 0.028) and an increase in HRV as measured by an increase in the high frequency fraction from 40.78 ± 3.86% to 65.04 ± 5.64 (n = 10, <i>P</i> = 0.005). …”

Physiological maturation in seeds of Lophantera lactescens Ducke by Patrícia Cândido da Cruz Silva (6299252)

Epoch Analysis of On-Treatment Disability Progression Events over Time in the Tysabri Observational Program (TOP) by Heinz Wiendl (237353)

“…Between months 13–24 and 25–36 of treatment, the proportion of patients with 6-month and 12-month confirmed EDSS progression decreased by 60% (from 7.5% to 3.0%; <i>p</i> < 0.01) and 58% (from 6.7% to 2.8%; <i>p</i> < 0.01), respectively. …”

Detection of SMN protein dose-response in SMA fibroblasts. by Dione T. Kobayashi (114574)

“…<p>SMA Type I fibroblasts (line GM03813) were treated for 24 h with the proteasome inhibitors MG132 or bortezomib (N = 2 each). <b>A</b>: A peak SMN protein upregulation of 27% was observed with 0.3 µM of MG132 (EC₅₀ = 0.68 uM) and a 67% increase was seen with 3 nM bortezomib (EC₅₀ = 10 nM). …”

Data collected during an investigation into uncertainty and impressions among people. by Zhijie Xie (9125206)

“…Using data collected in online surveys and psychology laboratory, we found that participants optimistically perceived the 50% acceptance probability, and that uncertainty enhances the impression of a target who has a 50% acceptance probability. …”

Quantification by Fourier Decomposition by Susanne E Hausselt (76318)

“…</p> <p>(B) Amplitudes (top) and relative phases (<i>ϕ</i>₂ − 2 · <i>ϕ</i>₁, bottom) versus frequency <i>(f )</i> for the averaged responses in (A). Symbols (<i>V</i>₀ at <i>f</i> = 0; <i>V</i>₁ at <i>f</i>₁; <i>V</i>₂, <i>V</i>₃... at 2·<i>f</i>₁, 3·<i>f</i>₁,...) are measured points; connecting lines are only a guide for the eye. …”

Table 3_Unveiling the immunological landscape of disseminated tuberculosis: a single-cell transcriptome perspective.xlsx by Zhen Gong (292434)

“…T cell pseudotime analysis indicated a decrease in the expression of most hypervariable genes over time, pointing to T cell functional exhaustion. …”

Image 3_Unveiling the immunological landscape of disseminated tuberculosis: a single-cell transcriptome perspective.jpeg by Zhen Gong (292434)

“…T cell pseudotime analysis indicated a decrease in the expression of most hypervariable genes over time, pointing to T cell functional exhaustion. …”

A Low Dose of Fermented Soy Germ Alleviates Gut Barrier Injury, Hyperalgesia and Faecal Protease Activity in a Rat Model of Inflammatory Bowel Disease by Lara Moussa (119193)

“…Macroscopic and microscopic damages, myeloperoxidase activity, cytokine levels, intestinal paracellular permeability, visceral sensitivity, faecal proteolytic activity and PAR-2 expression were assessed 24 h, 3 d and 5 d post-TNBS. FSG treatment improved the severity of colitis, by decreasing the TNBS-induced rise in gut permeability, visceral sensitivity, faecal proteolytic activity and PAR-2 expression at all post-TNBS points. …”

Data_Sheet_1_Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function.pdf by Victoria P. San Martín (6567683)

“…Single-channel recordings show that tropisetron inhibition is associated with a decrease in the open probability of the ion channel. …”

FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke by Robert Brunkhorst (405629)

“…However, the effects of a manipulation of S1P signaling at later time points after experimental stroke have not yet been investigated. …”

The stochastic switching trajectory and the rate change with the burst size. by Ruben Perez-Carrasco (1749952)

“…<p>(a) Changing the relative burst size <i>ν</i>_<i>A</i> = 1, 3, 5, 10 for both switching processes <i>A</i> → <i>B</i> (top) and <i>B</i> → <i>A</i> (bottom) alters the MAP. …”