Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering by Rui Xu (158313)

“…Mice on HFD developed diabetes and cardiac dysfunction with increased cardiac PDE4D5 expression. PDE4 inhibitor roflumilast can reverse hyperglycemia and cardiac dysfunction, accompanied by the decrease of PDE4D expression and increase of muscle-specific microRNA miR-1 level in hearts. …”

Table_1_Feeding Faba Beans (Vicia faba L.) Reduces Myocyte Metabolic Activity in Grass Carp (Ctenopharyngodon idellus).DOCX by Jing-jing Tian (778123)

“…<p>In this study, we aimed to explore the effects of faba bean (Vicia faba L.) on the energy metabolism of grass carp (Ctenopharyngodon idellus). A total of 180 fish (∼2900 g) were randomly assigned to six tanks (2.5 × 2.5 × 1.2 m; 30 individuals per tank) and fed either faba bean (Vicia faba L.) or a commercial diet for 120 days (3% body weight, twice per day). …”

Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia by Olivier Cases (760028)

“…Immunomorphological and ultrastructural analyses showed that increased eye lengthening was first observed by post-natal day 5 (P5) and that it was accompanied by a rapid decrease of the bipolar, photoreceptor and retinal ganglion cells, and eventually the optic nerve axons. …”

Table_1_Feeding Faba Beans (Vicia faba L.) Reduces Myocyte Metabolic Activity in Grass Carp (Ctenopharyngodon idellus).DOCX by Jing-jing Tian (778123)

“…<p>In this study, we aimed to explore the effects of faba bean (Vicia faba L.) on the energy metabolism of grass carp (Ctenopharyngodon idellus). A total of 180 fish (∼2900 g) were randomly assigned to six tanks (2.5 × 2.5 × 1.2 m; 30 individuals per tank) and fed either faba bean (Vicia faba L.) or a commercial diet for 120 days (3% body weight, twice per day). …”

Data_Sheet_1_Assessment of Climate Change Impacts on Chilling and Forcing for the Main Fresh Fruit Regions in Portugal.PDF by Helder Fraga (633694)

“…Future projections show a clear decrease in chilling for all regions and fruit types in Portugal. …”

Data_Sheet_3_Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.PDF by Martin Michaelis (23843)

“…Omeprazole 80 μg/mL caused a 10.8-fold (Vero cells) and 47.7-fold (HaCaT cells) decrease of the acyclovir concentrations that reduced HSV-1-induced CPE formation by 50% (IC₅₀). …”

Housing and road transport modify the brain neurotransmitter systems of pigs: Do pigs raised in different conditions cope differently with unknown environments? by Laura Arroyo (3422744)

“…After one month, one set of animals from each housing condition were driven in a truck to the slaughterhouse in low-stress conditions (5 min drive, no mixing groups, soft management, LS group, n = 12) or high-stress conditions (2 hours drive, mixing groups, harsh management, HS group, n = 12). …”

Data_Sheet_1_Preparation of nano-selenium from chestnut polysaccharide and characterization of its antioxidant activity.docx by Shanshan Wang (283009)

“…The DPPH free radical scavenging rate of purified polysaccharide fraction CP-1a was slightly enhanced, and the other rates showed a small decrease. …”

HCMV triggers cell proliferation via IL-6-STAT3 activation in HepG2 cells and PHH. by Quentin Lepiller (394353)

“…(C) Increased cell proliferation in HepG2 cells infected with AD169 is blocked by a neutralizing anti-IL-6R mAb (10 microg/ml), a Jak inhibitor (1 micromol/l) and a STAT3 inhibitor (10 micromol/l), and decreased cell proliferation was observed in HepG2 cells infected with UV-inactivated HCMV. …”

zVADfmk and zLLYfmk reduced the level of apoptosis during ex vivo expansion. by Sangeetha V. M (243677)

“…Data represented as mean positive population ± standard deviation from five independent experiments n = 5 (B) The presence of active caspases (Casp3/7) in the culture was assessed using a cell free cytosolic enzymatic assay and the zVADfmk/zLLYfmk sets showed a significant reduction in the activity of these caspases as assessed from four different CB units. …”

Spatially Defined InsP₃-Mediated Signaling in Embryonic Stem Cell-Derived Cardiomyocytes by Nidhi Kapoor (290320)

“…Buffering of InsP₃ by FIRE-1nuc had no effect on the basal frequency while attenuation of InsP₃ signaling throughout the cell (FIRE-1), or at the plasma membrane (m43) resulted in a 53.7% and 54.0% decrease in beating frequency. …”

RHO-1 regulates brood size. by Rachel McMullan (183027)

“…Expression of activated <i>hsRHO-1</i>(<i>G14V</i>) (<i>nzIs1</i>) or <i>hsC3 transferase</i> (<i>nzEx4</i>) resulted in a decrease in brood size.…”

Effect of <i>OPA1</i> or <i>Mfn1</i> silencing on mitochondrial Ca²⁺ uptake in permeabilized HeLa cells. by László Fülöp (203208)

“…<p>For the transfection protocol and measurement of fluorescence see legend of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025199#pone-0025199-g005" target="_blank">Figure 5</a>. …”

AE treatment induces autophagy, and inhibits angiogenesis and Hif-1α expression in xenografted tumors. by Alok De (446321)

“…Tissue sections were photographed at 400X magnification. The values are means <u>+</u> S.E.M. of 5 different mice. *, p<0.05, as compared with control group. …”

Forward scores follow exponential tails with constant <i>λ</i>. by Sean R. Eddy (5840)

“…Variation in is represented by plotting quartiles (black bars) and most extreme outliers (grey triangles) in addition to the means. approaches the conjectured log 2 as fitted tail mass decreases, but beyond a certain point, variance increases. …”

Integrating Building Information Management (BIM) in Civil Infrastructure Coordination: Application at LUSAIL Plaza by Abotaleb, Mohab Mohamed

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Backfilling Shaft Surround Using Recycled Concrete Waste Material by Brown, John

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Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis by Manresa M.C.

“…Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. …”
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Development of Semitransparent UV Photodetector Based on PTB7-Th:PCBM Composite Using the Cost-effective Fabrication Method by Riaz, Muhammad

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Suppressing Polysulfide Dissolution via Cohesive Forces by Interwoven Carbon Nanofibers for High-Areal-Capacity Lithium–Sulfur Batteries by Jong Hyuk Yun (4687930)

“…Thus, we demonstrate an electrospun carbon nanofiber (CNF) matrix for a sulfur cathode. This simple design enables a high mass loading of 10.5 mg cm^–2 with a high specific capacity and stable cycling. …”