Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients by A.R. Brunoni (5694239)

Depletion of EphA3 or EphA4 recovers the decreased ERK and Akt activation and lytic gene expression in RNF5 KO PEL cells. by Xiaojuan Li (351842)

Loss of <i>SLC4A11</i> expression in hCEnC leads to decreased cell barrier function. by Doug D. Chung (3611387)

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. by Brendan J. Tunstall (6593357)

“…<p>(A, Top) Representative GABA_A-mediated sIPSCs of CeA neurons from nondependent and dependent rats prior to (baseline) and during application of oxytocin (500 nM). …”

The GmNN1/FT2a-GmNFYA-C-GmENOD40 module regulates soybean nodulation. by Xinxin Li (281237)

High resolution structures visible with the 25 nm zone plate objective. by Kamal L. Nahas (13014698)

“…<p>139 CryoSXT tomograms were recorded from 107 cells using a 25 nm zone plate objective and several structures that were unrelated to HSV-1 infection were observed, including some that were not visible using the 40 nm zone plate objective. …”

I348T increases H77 entry dependency on SR-BI, while T385P decreases H77 entry dependency on SR-BI. by Christina Holmboe Olesen (11154333)

Respective increase and decrease in Myc and NRF1/TFAM in kidneys from rats administered Tl. by Sho Sugahara (11895828)

Increasing TPP side chain length decreases melanoma cell viability and clonogenic survival. by Kyle C. Kloepping (9928265)

“…The error bars for all data presented in Fig 2 represent the mean ± SEM. Results demonstrate that TPP derivatives decrease melanoma cell viability and clonogenic survival; and there is a structure-activity relationship between TPP side chain length and decreased viability and clonogenic survival.…”

MigC interacts with and decreases the activity of MurD. by Jeanette M. Critchlow (21553796)

CD5-2 decreases established CCM lesions in the hindbrain of <i>Ccm2</i>^<i>ECKO</i> mice and lesions in the retina of <i>Ccm2</i>^<i>ECKO</i> mice. by Jia Li (160557)

Structure of YOLOv5s-SBC. by Zhongjian Xie (4633099)

“…Compared to the original model, P-YOLOv5s-GRNF decreased parameters by 18%, decreased model size to 11.9MB, decreased FLOPs to 14.5G, and increased FPS by 4.3. …”

HCV infection decreases L1 retrotransposition frequency. by Anja Schöbel (10668438)

Coronavirus replication is decreased in AMPK-knockout (KO) cells. by Minsu Jang (2817730)

Germ cell size decreases before corpse formation. by Tea Kohlbrenner (19476160)

VPA treatment and senescence induction is associated with decreased neurogenesis. by Muriel Rhinn (406515)

Dynamin inhibitors decrease the viability of acute leukemia cells. by Christopher von Beek (11401835)

Tom clone number and area decrease during pupariation. by Jeremy Brown (3311742)