Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Elimination testing with adapted scoring reduces guessing and anxiety in multiple-choice assessments, but does not increase grade average in comparison with negative marking by Jef Vanderoost (5108072)

“…The comparison is structured around seven hypotheses: in comparison with negative marking, elimination testing with adapted scoring leads to (1) a similar average score (no grade inflation); (2) students expressing their partial knowledge; (3) a decrease in the number of blank answers; (4) no gender bias in the number of blank answers; (5) a reduction in guessing; (6) a decrease in self-reported test anxiety; and finally (7) students preferring elimination testing with adapted scoring over negative marking.…”

Calcareous nannofossil biostratigraphy of the Late Cretaceous‒early Paleocene interval in the Zagros basin (southeastern Tethys), Iran by Azam Mahanipour (10126937)

“…This study concentrates on two sections (the Gurpi and Kabir-Kuh sections) in the west and southwest of Iran in the Zagros Basin, which span biozones CC25c/UC20bTP to NP6/NTp10B in the Kabir-Kuh and CC25b/UC20aTP to NP5/NTp9 in the Gurpi section. Late Maastrichtian nannofossil abundance and diversity in the studied intervals is high with a sharp decrease slightly above the K/Pg boundary. …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-0 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Table_1_Trends in the Utilization of Teleneurology and Other Healthcare Resources Prior to and During the COVID-19 Pandemic in an Urban, Tertiary Health System.pdf by Benjamin R. Kummer (9743116)

“…Older age (aOR 0.98, 97.5%CI 0.98–0.99), female sex (aOR 0.90 97.5%CI 0.83–0.99), and Medicaid insurance (aOR 0.78, 0.68–0.90) were associated with decreased odds of loss to follow-up.…”

Ras transformation affects the circadian clock via MAPK signalling. by Angela Relógio (193817)

“…(<b>B</b>) Western Blot analysis of RAS protein expression for the HaCaT cell lines and its derivatives (HaCaTI7, HaCaTII4, A5RT3), shows clear RAS overexpression measured in A5RT3. …”

Behavioral Logic for Operant Training and Discrimination Testing by Samar B Mehta (274037)

“…As this behavior was established, <i>N</i> was increased from 0.063 s to 1.5 s.</p> <p>(C) Stimulus training. All trials in this stage were initiated by a 1.5-s nose poke. …”

Effects of ligand stimulation and targeted therapeutics on IGF1R and IR expression and phosphorylation. by Jurriaan Brouwer-Visser (578686)

“…Measured by RT-qPCR (n = 5 independent experiments each done in triplicate) IR-A and IR-B mRNA levels in HEY-T30 are significantly decreased when compared to HEY, while similar levels are observed when comparing A2780-T15 to A2780. …”

Data_Sheet_1_Data-Driven Modeling of Global Storm Surges.PDF by M. Tadesse (8762661)

“…For extreme events, the average correlation decreases to 0.54 (0.33) and RMSE increases to 14.5 (13.1) cm for extratropical (tropical) regions. …”

Supplementary Material for: Pharmacokinetic Properties of Dapagliflozin in Patients with Stage 4 Chronic Kidney Disease by figshare admin karger (2628495)

“…In the single dose group, dapagliflozin was rapidly absorbed and metabolized to produce dapagliflozin 3-O-glucuronide (D3OG) , with a mean Tmax of 0.7 hours and 1.8 hours, and a mean T1/2 of 16.7 hours and 14.9 hours, respectively. …”

Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis by Mei Yang (51996)

“…CK-18-M30 had 70% negative predictive value (NPV) and 79% positive predictive value (PPV) to diagnose NASH. A 5-step approach measuring CK-18-M30 followed by FGF21, IL-1Ra, PEDF and OPG gradually improved the NPV to 76% and PPV to 85%, which reached 80% and 76% respectively in the validation cohort.…”

DTA-1-mediated depletion of tumor-infiltrating CD4⁺ Foxp3⁺ Treg cells by ADCC. by Mikiya Ishihara (611835)

“…<p>(A) DTA-1- (dotted line) or isotype control (solid line)-treated CMS5a and murine GITR gene-transfected CMS5a (CMS5a/GITR) cells were stained with a FITC-conjugated anti-rat IgG (H+L) antibody and analyzed by flow cytometry. …”

DHEA and DHEA8354 suppress the growth of mammary tumors by Anne Shilkaitis (15502)

Microparticle ADPase inhibition using anti-CD39 monoclonal antibody. by Scott H. Visovatti (153660)

Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies by John J. Chen (353023)

The effects of β₁-adrenoceptor stimulation on I_Kur and I_Kto,f. by Vladimir E. Bondarenko (411443)

“…Simulated currents are obtained by 4.5-s depolarizing pulses to between −80 and +50 mV (in 10-mV increment) from a holding potential of −90 mV. …”

Activation of the PPARγ-LXRα-ABC transcriptional cascade by ghrelin is dependent on the PI3-K/Akt pathway. by Annie Demers (369643)

“…<p>(<b>A</b>) Role of the PI3-K pathway on gene expression analysis from THP-1 cells treated with 100 nM ghrelin and 5 nM LY294002 for 48 h. …”

RS modifies the BRL effects in RC cell population cultures. by Yuji Yoshiko (245190)

“…<p>Cells in osteogenic medium were chronically treated with or without BRL in combination with or without RS or fenofibrate for 14 days. (A and B) A combination of 100 nM BRL and 1–2.5% RS elicits a reciprocal increase in adipocytes (A) and decrease in bone nodules (B). …”

TLR2 mediates an inflammatory response in zymosan-induced arthritis (ZIA) by Matthias E Frasnelli (8777)

“…Histological scoring at day 25 of ZIA showed a significant decrease in cell infiltration in TLR2mice (< 0.02) compared with control mice, whereas cartilage destruction was similar in both groups. …”