Table1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.docx by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Table_1_Inhibitory and excitatory responses in the dorso-medial prefrontal cortex during threat processing.docx by Venkata C. Chirumamilla (6792758)

“…At source level, ICF led to an increase and short intracortical inhibition (SICI) to a decrease of theta power in the bilateral dmPFC, relative to single pulse TMS during 0–0.5 s. …”

Image2_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image3_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image_1_Inhibitory and excitatory responses in the dorso-medial prefrontal cortex during threat processing.TIF by Venkata C. Chirumamilla (6792758)

“…At source level, ICF led to an increase and short intracortical inhibition (SICI) to a decrease of theta power in the bilateral dmPFC, relative to single pulse TMS during 0–0.5 s. …”

Table1_Effects of 3-week repeated cold water immersion on leukocyte counts and cardiovascular factors: an exploratory study.docx by Ninja Versteeg (16894872)

“…</p><p>Methods: A total of n = 12, non-cold-adapted men (age: 25.2 ± 4.0 years; height: 177.8 ± 5.6 cm; weight: 73.8 ± 6.5 kg) were randomly allocated to the CWI or control (CON) group. …”

DataSheet1_Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus.zip by Xinrui Tan (12089750)

“…In addition, there was a decrease in prandial insulin dose (WMD, −4.23 IU; 95% CI, −5.26 to −3.20), basal insulin dose (−2.40 IU; −3.93 to −0.87), and total insulin dose (−5.73 IU; −10.61 to −0.86). …”

Nilotinib inhibits cell viability and neurosphere formation in medulloblastoma cells (MB-PDX and DAOY). by Kirti Kandhwal Chahal (7411091)

“…Nilotinib was observed to be most potent in inhibiting the formation of NS from single cells. (<b>f)</b> A representative Western blot for quantitation of nuclear Gli-1 in MB-PDX and DAOY cells shows a decrease in Gli-1 protein after treatment with 5 μM Nilotinib for 24 hours. …”

Deleting liver-innervating cholinergic neurons induces beiging of ingWAT. by Jiyeon Hwang (19747297)

“…(I) Western blot images showing a decrease in pS660-HSL expression in ingWAT of experimental mice relative to controls. …”

Data_Sheet_1_Efficacy of Ibandronate Loading Dose on Rapid Pain Relief in Patients With Non-Small Cell Lung Cancer and Cancer Induced Bone Pain: The NVALT-9 Trial.PDF by Anita J. W. M. Brouns (9019115)

“…Primary endpoint: bone pain response, defined as 25% decrease in worst pain score (PSc) over a 3-day period (day 5–7) compared to baseline PSc with maximum of 25% increase in mean analgesic consumption during the same period. …”

Fig 9 - by Adrian C. Shortall (10052871)

“…(b) The same data as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0245830#pone.0245830.g007" target="_blank">Fig 7A</a> normalized relative to the mean integrating sphere (100%) gold standard data.…”

The Association of Tobacco Control Policies and the Risk of Acute Myocardial Infarction Using Hospital Admissions Data by Carmen Jan (521526)

“…</p><p>Conclusions</p><p>The implementation of a CSB and TTI in Panama were associated with a decrease in tobacco consumption and a reduction of the RR of AMI.…”

Table_2_Early apixaban administration considering the size of infarction and functional outcome in acute ischemic stroke.DOCX by Min Hwan Lee (1657279)

“…Our study aims to investigate the potential benefits of stratified early administration of apixaban, taking into account infarct size during the acute phase, in order to enhance functional outcomes.</p>Methods<p>We conducted this study at a tertiary referral stroke center, enrolling acute AF-stroke patients who received apixaban during the acute phase. …”

Patient Age and the Prognosis of Idiopathic Membranous Nephropathy by Makoto Yamaguchi (588823)

“…A <25% decrease in proteinuria at 1 month after immunosuppressive therapy initiation also predicted infection (adjusted HR = 6.72, 95% CI: 1.51–37.8; <i>P</i> = 0.012).…”

Image 2_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-vil... by Kyosuke Kobayashi (21526655)

“…However, Caco-2 cells differ from living organisms in various ways. We have developed a human induced pluripotent stem cell-derived crypt-villus structural small intestine (hiPSC-SI) was established with a villus-like structure containing constituent cells of the small intestine.…”

Variation in Honey Bee Gut Microbial Diversity Affected by Ontogenetic Stage, Age and Geographic Location by Zuzana Hroncova (701561)

“…We found that bacterial counts do not show only yearly cycles within a colony, but vary on the individual level. …”

Data_Sheet_1_Impact of the COVID-19 Pandemic and Public Restrictions on Outcomes After Catheter Ablation of Atrial Fibrillation.PDF by Daehoon Kim (11601205)

“…</p>Conclusion<p>A decrease in AF recurrence after catheter ablation was observed in patients with paroxysmal AF during the COVID-19 outbreak, whereas no change was observed in those with persistent AF.…”

Presentation_1_Lactobacillus sakei WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice.pptx by Min-Sung Kwon (394679)

“…We also investigated the inhibitory capacity of WIKIM30 on the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD), a Th2-dominant allergic disease in mice. …”

Table_1_The Adipose Microenvironment Dysregulates the Mammary Myoepithelial Cells and Could Participate to the Progression of Breast Cancer.XLSX by Laetitia Delort (390472)

“…We found that adipose cells (precursors and differentiated adipocytes) could decrease the viability of the MECs, regardless of the original BMI. …”