The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Statins and Hip Fracture Prevention – A Population Based Cohort Study in Women by Arja Helin-Salmivaara (123653)

“…In the hypertension and the population cohorts, the rates were 2.0 per 1000 py (312 fractures per 157 090 py) and 1.0 per 1000 py (212 fractures per 216 329 py), respectively. Adjusting for a propensity score and individual variables strongly predicting the outcome, good adherence to statins for five years was associated with a 29% decreased risk (HR 0.71; 95% CI 0.58–0.86) of a low-energy hip fracture in comparison with adherent use of hypertension drugs. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Circulating TRAIL Shows a Significant Post-Partum Decline Associated to Stressful Conditions by Giorgio Zauli (191939)

“…</p> <h3>Conclusions</h3><p>Stressful partum conditions and elevated CRP levels are associated with a decrease of circulating TRAIL.</p> </div>…”

Repetitive stress induces a reduction in sound-evoked activity that develops as the stressor becomes chronic. by Ghattas Bisharat (20706928)

“…<p>(a) Change of tone-evoked activity over time. Comparison of tone-evoked activity after a day and 5 days of stress to baseline. …”

Cost-effectiveness of maternal influenza immunization in Bamako, Mali: A decision analysis by Evan W. Orenstein (130613)

Dynamics of Premixed Hydrogen-Air Flames in Microchannels with a Wall Temperature Gradient by Aswathy Nair (753246)

“…Detailed studies on the formation of flames with repetitive extinction and ignition (FREI) mode have been carried out for a 0.75-mm diameter tube with fixed conditions of flow velocity of 10 cm/s and Φ = 0.5–1.0 with wall temperature linearly varying from 300 K to 960 K. …”

Neoadjuvant chemotherapy for muscle invasive bladder cancer: a nationwide investigation on survival by Beth Russell (5095202)

“…This study calculated 5-year survival and risk of bladder cancer (BC)-specific and overall death by Cox proportional hazard models for the study cohort and a propensity score (PS) matched cohort.…”

Degradation of aggregate-prone αA-crystallin mutant, R116C. by Ilangovan Raju (333566)

“…For each of the sample, 5 µg of total protein was loaded and western blot probed with an anti-αA-crystallin (rabbit polyclonal, Enzo Life Sciences Inc., Catalog # SPA-221). …”

A standardized post-cesarean analgesia regimen reduces postpartum opioid use by Melissa F. Meyer (11339199)

“…</p> <p>To determine if implementation of a standardized postoperative analgesic regimen decreases opioid use following cesarean birth.…”

The QSAR-search of effective agents towards coronaviruses applying the Monte Carlo method by A.A. Toropov (6732974)

“…A collection of possible biologically active compounds, constructed using data on the above molecular features which are statistically reliable promoters of increase or decrease of the activity, is presented.…”

Dataset for: The thermodynamic basis of glucose stimulated insulin release: a model of the core mechanism. by David F Wilson (4048306)

“…Applied to the reported glucose concentration dependent release of insulin by perifused islet preparations (4), the model predicts that the dependence of insulin release on [ADP] is strongly cooperative with a threshold of about 30 µM and a negative Hill coefficient near -5.5. …”

Data_Sheet_2_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

Data_Sheet_3_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

Data_Sheet_1_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

Validation of ING3 in combination with AZD5582 as a HIV-1 latency maintenance factor. by Emily Hsieh (377992)

“…<p><b>(A)</b> HIV-1 reverse transcriptase activity (y-axis) of the viral supernatant of NTC sgRNA transduction or <i>ING3</i> knockout in J-Lat 10.6 and 5A8 treated with 10 nM AZD5582 or an equivalent volume of DMSO. …”

RbmB digests VPS <i>in vitro</i>. by Ranjuna Weerasekera (20371182)

“…Increasing amounts of RbmB show a decrease in the aggregates and increase in free Bap1, suggesting cleavage of VPS into small fragments. …”

A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis by Patricia Taschner Goldenstein (5570870)

“…</p><p>Results</p><p>Calcium mass transfer varied widely among patients in each study phase with a median of -89.5, -76.8 and -3 mmol using d[Ca] 1.25 mmol/L, -106, -26.8 and 29.7 mmol using d[Ca] 1.50 mmol/L, and 12.8, -14.5 and 38 mmol using d[Ca] 1.75 mmol/L during pre-PTX, early post-PTX and late post-PTX, respectively, which was significantly different among d[Ca] (p = 0.0001) and among phases (p = 0.040). …”